Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"zygotic genome activation"”.
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
The maternal-to-zygotic transition in mammals consist of the passing of the developmental control from the mother to the embryo and involves two major events: the depletion of maternal products and the activation of the zygotic genome. Zygotic genome activation, or ZGA, coincides with dramatic …
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
… resumption of an oocyte when the translational activation of the dormant mRNAs takes place, followed by their gradual elimination in the zygote, and ending with the full transcriptional activation of the newly reprogrammed embryonic genome. All these complex processes constitute the maternal to …
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Karyopherin alpha subtypes and porcine early stage embryo development
… cargoes that are directly involved in zygotic genome activation, or that direct development immediately after zygotic genome activation, hence affecting early cleavage embryo development.</p>
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Role Of Maternal Sin3a In Reprogramming Gene Expression During Mouse Preimplantation Development
In mouse, the maternal-to-zygotic transition entails a dramatic reprogramming of gene expression during the course of zygotic genome activation, which is essential for continued development beyond the 2-cell stage. Superimposed on zygotic genome activation and reprogramming of gene expression is …
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Potential roles for Elf3 in fetal alcohol spectrum disorder and development
… the expression pattern of elf3 in relation to zygotic genome activation. Translation blocking morpholino oligonucleotides were used to implicate Elf3 in epiboly movements during gastrulation and zebrafish tail development. Taken together these results help to strengthen the zebrafish as a model …
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Precise Temporal Regulation of Ribonucleoprotein Complexes during the Drosophila Maternal-to-Zygotic Transition
… development prior to the handover of control to zygotically expressed gene products in a process known as the maternal-to-zygotic transition (MZT). RNA-binding proteins (RBPs) tightly regulate the translation, stability, and localization of maternal mRNAs through post-transcriptional regulatory …
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MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT
… which is required for meiosis I in mice and for zygotic genome activation (ZGA) in Ciona intestinalis. In humans, CCNB3 mutations cause recurrent pregnancy loss. We explored meiotic and post-meiotic roles of CCNB3 using imaging studies, fertility tests, and pronuclei swap experiments. Ccnb3-/- …
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Stage-specific profiling of the transcriptome during oogenesis and identification of a novel type of small RNA within the zebrafish ($\textit{Danio rerio}$)
… and providing the transcripts required prior to zygotic genome activation, but the timing of the production of these transcripts is unknown. To be accurately localized within the embryo, these transcripts are deposited prior to fertilization, during egg development (oogenesis). The oocyte goes …
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Investigating the mechanisms and the temporal regulation of the first cell polarity establishment in the mouse embryo
… in the formation of actomyosin ring. The activation and assembly of actomyosin meshwork during the first phase, but not its contractility, was essential for apical protein recruitment. Factors responsible for actin cytoskeleton reorganisation included Phospholipase C (PLC) – Protein Kinase …
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Characterization of Maternal Factor MOF/H4K16ac and the Impact of the Cryostress on Bovine Embryonic Development
… and 2) the changes to the transcriptome and epigenome induced by standard and Ultra-fast cool vitrification followed by thawing in blastocysts (Chapter III). In Chapter II, we found the higher enrichment of MOF at both mRNA and protein levels during oogenesis. The abundance of MOF protein in …
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The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
… degraded and development is controlled by the zygotic genome. Zygotic genome activation (ZGA) is critical for successful embryogenesis, and yet the precise mechanisms of its regulation remain elusive. The first aim of this thesis was to assess the contribution of inherited cell cycle regulators …
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Analyses of RNA dynamics in Mus musculus
Ribonucleic acid (RNA) is a biological molecule that exists in the cell of virtually all kinds of known living organisms. Although its significance in fundamental cellular processes such as protein synthesis has been known for decades, an increasing number of novel species and functions of RNA have …