Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"zinc finger protein"”.
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Studies of the MYM-type zinc finger protein ZMYM3
… a transcription factor, and ZMYM3, an MYM-type zinc finger protein of unknown function. By making several truncation mutants of ZMYM3, I show that a C-terminal region containing a ‘PXP’ repeat motif mediates its interaction with RNase H2, and that the PXP-containing proteins ZMYM2 and ZMYM4 …
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Characterisation of the non-canonical zinc finger protein ZFP263 in mouse
… and relies on chromatin structure and regulatory proteins. One of the largest families of DNA-binding factors that influence this in human and mouse is the KRAB zinc finger protein (KZFP) family. KZFPs are thought to have rapidly evolved alongside transposable elements and be mediators of …
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Uncovering the Roles of Human C2H2-Zinc Finger Protein ZNF121 in Gene Regulation
… II is coordinated by an elegant arrangement of protein machinery and chromatin architecture, and the resulting pre-mRNA is post-transcriptionally processed and regulated at every step to buffer, reduce, or amplify its protein output. Chemical nucleotide modifications on DNA or RNA are one type …
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Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
The Zinc finger protein 36 like 1 (ZFP36L1) or Butyrate response factor 1 (BRF1) is involved in the differentiation, proliferation, and angiogenesis of various cell types. ZFP36L1 can positively or negatively regulate cellular processes such as transcription and signalling, depending on external …
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The KRAB Zinc Finger Protein ZKSCAN3 binds to a SINE-embedded regulatory sequence to repress enhancer activity
KRAB Zinc Finger Proteins (KZFPs) are the largest family of transcription factors in mammals and are generally associated with the binding and repression of transposable elements. KZFPs use their KRAB domain to recruit the cofactor KAP1, which acts as a scaffold for the induction of …
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The development of a model system and high throughput assay for the study of interactions between zinc finger proteins and DNA
… which utilise small DNA binding motifs called zinc fingers, are presently employed. None of the current approaches successfully combine a combinatorial approach to the elucidation of a code with a single stage high throughput screening assay. The work outlined here describes the development of …
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Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies
… are Cul3 and Chinmo. Cul3 encodes a scaffold protein for E3 ubiquitin ligase. Phenotypic analysis demonstrates that Cul3 is required for proper axon arborization and dendritic elaboration of MB neurons. Chinmo is a novel BTB-zinc finger protein. Functional analysis shows that Chinmo is an …
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A two-color bacterial two-hybrid system for selecting sequence-specific DNA-binding proteins via fluorescence activated cell sorting
Proteins that recognize specific DNA sequences play a major role in many biological processes, and the ability to select or design novel DNA binding proteins could have a major impact on many areas of biotechnology and medicine. This thesis begins with background information on zinc finger …
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Investigation of DNA methylation at the promoter region of the aralkylamine N-acetyltransferase (AANAT ) gene in South African children with Autism Spectrum Disorder
… factor (TF) binding motifs for ZID (zinc finger protein with interaction domain), MEIS1 (Meis homeobox 1) and ZIC1 (zinc finger protein of the cerebellum 1) were identified at or near to CpG 3. These three TFs have known gene ontology terms that relate to neurodevelopment. The age of …
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High throughput profiling of transcription factors involved in soybean root growth under water deficit
… responses to water deficits. Among these were zinc-finger protein, MYB-related protein, GmNAC3, GmNAC4, and bZIP transcription factors. These TFs were differentially expressed in distinct root regions, and therefore they can be targeted for functional characterization and further genetic …
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Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… migration. I also implicate a conserved PHD zinc finger protein ZFP-1/AF10 and endogenous RNAi in the regulation of HSN migration. I determine that ZFP-1 affects HSN migration in part through its negative effect on the transcription of the conserved insulin/IGF-1 signaling kinase gene pdk-1 …
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Apport de données d’ADN nucléaire à la Phylogénie et à la Biologie de la Conservation des Ursidae
… region of the Y chromosome), ZFX/ZFY (Zinc Finger protein) and AMLX/AMLY (Amelogenine), we developed a reliable method to determine the sex of Ursidae based on the analysis of DNA extracted from non invasive samples such as hairs or faeces. If this tool has obvious implication for the …
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Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
The pox-virus zinc finger protein (POZ-ZF), also termed leukemia/lymphoma related factor (LRF) belongs to the POK family of transcriptional repressors, which is also known as POK erythroid myeloid ontogenic factor (Pokemon), factor binding to short transcripts of HIV-1 (FBI-1), and TTF-1 …
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Delineating the Mechanisms Through Which ZNF165 Supports Growth and Survival of Triple-Negative Breast Cancer
Cancer/testis (CT) antigens are proteins whose expression is normally restricted to germ cells yet aberrantly activated in tumors, where their functions remain relatively cryptic. The transcription factor ZNF165, a CT antigen frequently expressed in triple-negative breast cancer (TNBC), was …
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Analysis of Immediate-Early Gene Expression in the Songbird Brain Following Song Presentation
… homologue is described, an IEG that encodes a zinc-finger protein and which is highly sensitive to growth factors and depolarizing stimulation, including stimuli leading to LTP induction in the mammalian hippocampus. Two methods were used to study gene regulation: administration of metrazole, a …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
The zinc finger protein and transcription factor, KLF4, plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in …
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Investigation of factors involved in RNAi-mediated heterochromatic silencing in Schizosaccharomyces pombe
… structure composed of DNA and specialised proteins that packages DNA to fit inside the nucleus, regulates gene expression and ensures genome stability. Heterochromatin is a repressive form of chromatin found at repetitive sequences such as centromeres, telomeres and transposons. …
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In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… estrogen receptor 1 (ESRl) and mitogen-activated protein kinase 3 (MAPK3) was identified. Real-time RT-PCR confirmed the differential expression of 8 genes, including ESRl, MAPK3, MECP2 (methly CpG binding protein 2), PSTPIPI (proline-serine-threonine phosphatase interacting protein 1), SLA …
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Characterizing RNA translocation in the parasitic weed Cuscuta pentagona
… Arabidopsis, Translationally Controlled Tumor Protein (AtTCTP), Auxin Response Factor (AtARF) and a Salt-inducible Zinc Finger Protein (AtSZFP) supported the idea that mRNA molecules differ in their mechanisms of uptake and mobility between host and parasite. Known phloem-mobile RNAs (SlGAI and …
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Function of Znf668 In Cancer Development
… in oncogenes and tumor suppressor genes. <em>Zinc finger protein 668 (ZNF668)</em> has recently been identified and validated as one of the highly mutated genes in breast cancer, but its function is entirely unknown. Here, we report two major functions of ZNF668 in cancer development.</p> …
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