Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"zeta chain"”.
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Zeta-Ketten Expression bei Patienten mit SCCHN und dendritische Zellen als Stimulatoren für T-Zellen In Vitro
Introduction The zeta-chain as an important component of the T cell receptor (TCR) is involved in the transduction of intracellular signals and is therefore critical for T cell activation and subsequent induction of an anti-tumor response. In patients with squamous cell carcinoma of the head and …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… and transmembrane domains of the beta chain of human major histocompatibility complex (MHC) class II molecule and the cytoplasmic zeta chain of T cell receptor and pairing it to the alpha chain linked to zeta. CD8<sup>+ </sup>receptor-modified T-cells (RMTC) were able to recognize the …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
… which is associated with six invariant signaling chains, termed the CD3 subunits. These are organized into two independent signaling modules, the CD3 gamma epsilon / delta epsilon heterodimer ?and the CD3 zeta zeta?homodimer. In their cytoplasmic tail, the CD3 chains contain multiple copies of a …
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Development of a canine model to evaluate CAR-T cell subsets
… frequently built from the fused heavy and light chains of an antibody, called a single chain fragmented variable (scFv) domain, and confers the CAR its tumor specificity. Intracellular signaling domains typically contain the zeta chain of CD3 along with one or more costimulatory domains, often …