Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"zero-order release"”.
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Design and in vitro development of resorbable urologic drug delivery device
Implantable, controlled release drug delivery devices offer several advantages over systemic oral administration routes and immediate drug release treatments including direct therapy to target organ, more continuous maintenance of plasma and tissue drug levels and the potential for reduced side …
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SILOXANE-CONTAINING PHOSPHOLIPIDS AS POTENTIAL DRUG DELIVERY SYSTEMS
… of drugs, stability of liposomes and drug release profile. Optimizing any of these characteristics will hence improve the efficiency of liposomes as DDS. This study reveals the potential for siloxane-containing phospholipids to display a higher entrapment capacity than conventional …
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Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… that all NP formulations are non-toxic. In vitro release of prodrugs from NP showed a biphasic release pattern with an initial burst phase followed by a sustained phase. Such burst effect was completely eliminated when NP were suspended in thermosensitive gels with near zero-order release …
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Biological applications of weal polyelectrolyte multilayers
… multilayers as a delivery system for controlled release of small molecule drugs. The loading and releasing properties of porous PAH/PAA multilayers were investigated using the two drugs, ketoprofen and cytochalasin D. It was determined that the amount of drug released was proportional to the …
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Nanoparticles Targeting at Inflammation Site
… PLGA—were investigated for their distinct drug release kinetics. PEG-b-PCL enabled prolonged, near zero-order release, whereas PLGA exhibited a rapid burst release. These insights informed the development of a clinically translatable formulation, PEG-PCL-NanoPaz-t, produced via flash …
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Effect of ethyl oleate and oleic anhydride on metronidazole release from poly(ortho esters) films
… oleic acid, were compared with regard to the release characteristics of metronidazole (1 0% w/w) from poly( ortho esters) films in distilled water at 3 7 °C. The rate of release of metronidazole from poly(miho esters) films was dependent on the ethyl oleate or oleic anhydride concentrations. …
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Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)
… solutions showed a decrease in migration on the order of 20% when appropriate powder bed additives were introduced. Migration was also decreased by pre-printing barriers to confine secondary printed drug solutions. Low dosage forms were fabricated with as little as 2.3 nanograms. Lower dosages …
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Mucoadhesive buccal tablets for the delivery of nicotine and Delta9-tetrahydrocannabinol.
… of existing NRT treatments. Controlled release layers were prepared using crystalline nicotine hydrogen tartrate salt in a dry blend with adhesive and controlled release excipients. Powder blends were compressed to form 6 mm tablets. Release profiles indicated that a combined matrix of …
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Bioresorbable Osmotic Pump for Long–term Contraception
… systems raise problems like inconstant release rates that compromise their long-term efficacy, the requirement of surgical removal, and a long pharmacokinetic tail that delays the user’s return to fertility. Here, we investigated a fully bioresorbable osmotic pump system that provides …
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Toward a drug delivery coating for intraocular lenses
… focused on rational polymer design for tailored release, incorporation of hydrophobic small molecule therapeutics, and controlled multi-agent release. Fabrication rules and design tools necessary to create hydrolytically degradable polyelectrolyte multilayer films with preprogrammed advanced …
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Local drug delivery for treatment of brain tumor associated edema
… and a cap with orifice(s) through which drug is released. Drug release kinetics is dependent on the payload, the drug solubility, and the surface area for diffusion. Sustained releases of dexamethasone (DXM), dexamethasone sodium phosphate (DSP), and solid dispersion of cediranib (AZD/PVP) were …
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Performance and characteristics of controlled release matrices composed of hydroxpropylmethylcellulose and other polymers.
… combination with other adjuncts, to control the release of propranolol hydrochloride from matrices. Gels were characterized by U tube viscometry and their cloud points of gels. The properties of polymers and their mixture in matrices or in gels were investigated by differential scanning …
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Development of Polymeric Nanocarriers for Dual Magnetic Resonance Imaging and Drug Delivery
… cationic antibiotic gentamicin (31 wt%). A near zero-order release of gentamicin (pH 7.4 in PBS) that reached ~35 wt% of the initial gentamicin within 10 hours was observed, and this was followed by slower release of another 7 % by 18 hours. These nanoparticles were efficiently taken up by …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… (HPMC) were used as the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm …
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Oral Drug Delivery -- Molecular Design and Transport Modeling
… two well-known models, namely the drug release model (dissolution model) with a drug transport model (compartmental absorption and transit (CAT) model) to predict the release, distribution, absorption and elimination of an oral drug through the gastrointestinal (GI) tract of the human …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug …
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EVALUATION OF HYDROLYTIC ENZYMES IN THE DESIGN OF ORAL DRUG DELIVERY SYSTEMS
… activity of the enzyme cellulase to improve the release performance of oral modified release dosage forms having as functional polymer hydroxypropyl methylcellulose (HPMC), a hydrophilic cellulose derivative which is substrate of the enzyme itself. Previous examples of the use of enzymes in drug …