Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"zebularine"”.
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… recently discovered DNA methylation inhibitor, zebularine – considered more stable than 5-Aza-dC – was also able to reconstitute p15 mRNA in vitro in association with promoter demethylation, regional enrichment of histone acetylation, and growth inhibition. To identify novel genes silenced by …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… pretreatment of B16 melanoma cells with zebularine, a DNA methyltransferase inhibitor, followed by G3YSD-encoding dendrons significantly increased levels of cytotoxic T lymphocyte-mediated lysis in a physiologically relevant co-culture. Developing novel architectures capable of …
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Effetto dell’etanolo sullo stato di metilazione del gene che codifica per la neurotrofina “Brain-Derived Neurotrophic Factor”
… induced by the two DNA methylation inhibitors, zebularine and RG-108, exposure of cultured neurons to 100 mM ethanol for 3h significantly increased the unmethylated state of BDNF exon IX that was about 2.5 folds grater than the methylated state. This epigenetic action of ethanol was observed …