Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 84 for “"zebrafish (Danio rerio)"”.
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Xenobiotic metabolism and zebrafish (danio rerio) larvae
… of the metabolism of xenobiotics in zebrafish larvae, due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were demonstrated to be expressed during …
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Behaviour and morphology of the zebrafish, danio rerio
… organisms are needed. It is proposed that the zebrafish, Danio rerio, a species well suited to the laboratory environment and with much information available about its genetics, has potential in this area. However, currently little is know about mate choice in this species and whether its …
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The Effects of noise of Zebrafish (Danio rerio) memory
… of white noise on the cognitive performance of zebrafish (Danio rerio) and its possible mechanism of action, focusing on GABA neurotransmitter levels in the brain. To this end, adult zebrafish were exposed to four sound treatments: a medium intensity sound presented in either a regular and …
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Modeling and Mapping Addiction in the Zebrafish, Danio rerio
… have not yet been modeled and correlated in zebrafish, a viable translational model for studying drug addiction. In the present study, addictive behaviors in zebrafish were elicited after fish were exposed to amphetamines through a condition place preference paradigm. After the conditioning …
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Alzheimer's disease genes in zebrafish (Danio rerio) / Casper Groth.
… during embryo development using the zebra fish (Danio rerio) as a model organism.
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The Effects of Benzyl Alcohol on Developing Zebrafish (Danio rerio)
… effects of benzyl alcohol exposure on zebrafish (Danio rerio), a well-established model for development. Zebrafish were exposed starting at high blastula stage of development (4 hours post-fertilization, hpf) and finishing at free swimming larvae stage (144 hpf). Observations of …
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Identifying the Origin of Zebrafish (Danio rerio) Renal Progenitor Cells
The zebrafish kidney can be distinguished from the human kidney by the presence of adult renal progenitor cells (RPCs) that are capable of neonephrogenesis. These cells can be labeled with eGFP in the Tg(lhx1a:egfp) transgenic line. Using this transgenic line, zebrafish kidney regeneration was …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… toxicity of chronic dietary arsenic exposure in zebrafish (Danio rerio), with a focus on sex-specific susceptibility, epigenetic alterations, and lineage-dependent inheritance patterns. In the first study (Chapter 2), adult zebrafish were exposed to environmentally relevant dietary arsenic …
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The Neuroinflammatory Effects of Chronic Unpredictable Stress on Zebrafish, Danio rerio
… needs. </p> <p> In this study, we used the zebrafish to model PSTD by implementing a chronic unpredictable stress paradigm to simulate a traumatic experience. We measured behavior differences using an anxiety-like behavior assay, the Light-Dark Preference Test, and attempted to validate our …
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Molecular and Functional Analysis of Otolith Formation in Zebrafish, Danio Rerio
"Mammalian otoconia and fish otoliths are calcium-carbonate biominerals and important inner-ear organs that detect linear accelerations and perceive gravity. As a result, the absence, degradation, or dislocation of these structures causes severe imbalance in affected animals. The common vestibular …
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A Larval Zebrafish (Danio Rerio) Model of Adherent-Invasive Escherichia Coli Infections
… <em>in vivo</em> remains unclear. Here a larval zebrafish (<em>Danio rerio</em>) model of AIEC was established, which facilitates the study of the role of pre-existing inflammation, and host- and pathogen- genetic factors during IBD pathogenesis. Paramecium caudatum, a natural prey of zebrafish …
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Loss of rad51 in zebrafish (Danio rerio): a novel Fanconi anaemia model
… of RAD51 loss. Phenotypic characterisation of zebrafish rad51 loss-of-function mutants showed that they develop key features of FA, including hypocellular kidney marrow, sensitivity to crosslinking agents and decreased size. Taking advantage of the unique properties of the zebrafish model, I …
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Auditory Hair Cell Regeneration and Gene Expression in Noise-Exposed Zebrafish (Danio rerio)
… cell regeneration has not been characterized for zebrafish, nor has gene expression following noise exposure. To establish a time course of hair cell regeneration, adult zebrafish were exposed to a 100 Hz pure tone at 179 dB re 1 |u.Pa RMS for 36 hours, and then allowed to recover for 0 to 14 days …
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Exploring combined effects of arsenic and selenium exposure on larval zebrafish (Danio rerio)
… on aquatic life. To investigate this interplay, zebrafish embryos were exposed to As alone (as arsenite) or in combination with two different chemical forms of Se including As 120 μg/L alone (as arsenite), As 120 μg/L + Se 25 μg/L (as selenite), As 120 μg/L + Se 120 μg/L (as selenite), and As 120 …
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Role of GnIH and GnRH in Paracrine Control of Gametogenesis in Zebrafish (Danio rerio)
… main goal of my thesis was to study the role of zebrafish GnIH (zGnIH) and GnRH peptides, which are locally produced in the gonads, in the regulation of basal and gonadotropin hormone (GTH)-induced spermatogenesis and final oocyte maturation in zebrafish, in vitro. The findings highlight the …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… fish predicts functional effects, using larval zebrafish (Danio rerio) as a model system. The study focuses on nine widely prescribed and environmentally relevant compounds: three anticonvulsants (carbamazepine, lamotrigine, gabapentin), three antidepressants (venlafaxine, escitalopram, …
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Toxicity of aliphatic amines on the embryos of zebrafish Danio rerio - experimental studies and QSAR
… of 36 aliphatic amines on the embryos of the zebrafish Danio rerio were investigated. The DarT (Danio rerio Toxicity assay) was used to determine the lethal concentrations within a 48 h static acute toxicity test. A QSAR (Quantitative Structure-Activity Relationship) was performed using the …
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Assessing the impact of domoic acid exposure on the zebrafish (Danio rerio) brain across life stages
… altered gene expression patterns in the adult zebrafish brain. These changes were distinct from those resulting from symptomatic exposure, suggesting that low levels of DA could affect brain function in unique ways. In the second data chapter, I investigated the effect of developmental exposure …
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ZEBRAFISH (DANIO RERIO) AS A MODEL SYSTEM FOR THE FUNCTIONALVALIDATION OF CANDIDATE GENES FOR HUMAN DISEASES
In recent years, zebrafish (Danio rerio) has become increasingly utilized as a model for studying human gene functions and associated diseases. This has been possible due to the very high conservation of genes and of organs and systems which are fully functional within the very first days of …
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