Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 483 for “"zebrafish"”.
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Zebrafish : a steganographic system
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
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Zebrafish Models of KATP Channelopathies
… described in this thesis initially considers zebrafish as a model organism to further understand KATP channel physiology, pathology, and pharmacology. Detailed methods are described to isolate cardiac and vascular myocytes for patch-clamp studies. Using these methods, the molecular make-up and …
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Analysis of the Zebrafish Segmentation Clock
… the anterior of the PSM. This thesis shows the zebrafish RA catabolism mutant <i>giraffe</i> has an altered cyclic gene wave pattern, an observation that suggests that rather than stop their oscillations, cells tune their frequencies in response to RA signalling, introducing a novel function for …
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Biological Confinement of Zebrafish Using RNAi
… as a biological tool is still relatively new in zebrafish, recent work has explored elements of this mechanism allowing for greater knockdown efficiencies. The deadend (dnd) gene is required for primordial germ cell (PGC) development and survival. Previous studies have shown that zebrafish dnd …
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Somatic cell nuclear transfer in zebrafish
Thesis (Ph. D.)--Michigan State University. Comparative Medicine and Integrative Biology, 2010
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Intravital imaging of metastasis in zebrafish
… to the challenge. The development of a line of zebrafish, Casper, that is transparent throughout its life suggested that zebrafish might be a powerful system for intravital imaging. I first developed novel injection and imaging techniques to study metastasis through intravital imaging in adult …
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Characterization of zebrafish zipper-interacting protein kinase
… we completed several experiments to examine zebrafish ZIPK in development and its effect on acto-myosin contractility. It was found that zebrafish ZIPK was expressed ubiquitously in maternal stages. In zygotic stages, ZIPK expression dropped dramatically and localized to the anterior portions …
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Visual perception of social groups in zebrafish
… I address these questions in adult and juvenile zebrafish by combining behavioural assays with two-photon calcium imaging. In particular, I investigate how specific group visual features - such as number of elements, speed and overall amount of motion - might influence shoaling behaviour and be …
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Synapse Formation in the Zebrafish Lateral Line
… partners are matched for synapse formation. The zebrafish lateral line offers the opportunity for greater insight into this process. Hair cells in the lateral-line neuromast exist as two intermingled subpopulations, anteriorly and posteriorly polarized cells. Afferent neurons form synapses with …
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Synaptic Specificity in the Zebrafish Lateral Line
… The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here I show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. I …
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Dynamics and Mechanics of Zebrafish Embryonic Tissues
… the mechanical and dynamical properties of zebrafish embryonic cells and tissues. This thesis is structured as follows: In chapter 2, we introduce the fundamental concepts that are important for the study of cell motion during zebrafish embryonic development. In chapter 3, the materials and …
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BEHAVIOURAL ANALYSIS OF ZEBRAFISH RELAXIN-3A MUTANT
… This thesis explores the <i>rln3a</i> gene in zebrafish, to test whether these roles are evolutionarily conserved. Using CRISPR/Cas9, a 7 bp deletion was generated in the <i>rln3a</i> locus. Mutants showed mild changes in body weight, anxiety and visuomotor response compared to wildtype …
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Transcriptomic analysis of pancreatic cells in zebrafish
… signatures of each pancreatic cell type in zebrafish in order to identify novel cell type-specific regulatory genes that might be crucial for their differentiation and/or physiology. Pancreatic acinar cells, ductal cells as well as the endocrine α-, β- and δ-cells were isolated from …
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Understanding Positional Information During Zebrafish Fin Regeneration
… remained elusive. This dissertation establishes zebrafish pectoral fins as a model system for studying and defining positional memory factors. This has been accomplished through careful morphological measurements, gene expression profiling, construction of transgenic zebrafish strains, and the …
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Xenobiotic metabolism and zebrafish (danio rerio) larvae
… of the metabolism of xenobiotics in zebrafish larvae, due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were demonstrated to be expressed during …
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Idenficiation of the zebrafish primordial germ cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Modular, Open-Source Instrumentation for Zebrafish Larvae Research
… and software platforms designed to support zebrafish larvae research. The Agarose Stamping Device provides reproducible larval immobilization with high positional repeatability, replacing fragile manual techniques with a standardized process that can be fabricated, modified, and shared …
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Functional analysis of tcf21 and tbx20 in zebrafish
In response to cardiac cell death from an injury, zebrafish, as opposed to mammals, are able to regenerate new heart cells without significant scar tissue. Heart attacks, a leading cause of death in the United States, leave behind substantial scar tissue that weakens the heart and leads to a …
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Classifying drug-induced epileptic seizures in zebrafish larvae
Zebrafish (Danio rerio) is one of the model organisms used for epilepsy research and have been found to have enormous potential for modelling acute seizures and genetic epilepsies. In this project, a mathematical classification model was created with the aim of correctly classifying zebrafish …
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Mechanisms of Copper-Dependent Notochord Formation in Zebrafish
… elucidated the phenotype of copper deficiency in zebrafish, which includes a strikingly distorted notochord. The studies described here establish the specific genetic etiology of this distortion and reveal a number of gene-gene and gene-nutrient interactions critical to notochord morphogenesis. We …
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