Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"y-Secretase"”.
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Sodium dichloroacetate (DCA) impairs β-secretase-mediated proteolysis of the alzheimer's disease amyloid precursor protein (APP)
… of the amyloid precursor protein (APP) by y-secretase yielding soluble APPbeta (sAPPβ) and a membraneassociated C-terminal fragment, C99. The latter fragment is then cleaved by a-secretase liberating the toxic Aβ-peptides. Alternatively, APP can be cleaved non-amyloidogenically by an …
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Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis
… characterized as the catalytic subunits of the γ-secretase protease complexes, the presenilins are responsible for the cleavage of the amyloid precursor protein (APP) and generation of amyloid beta (Aβ). To date, γ-secretase proteases have over 120 substrates which demonstrate contribution to a …