Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 182 for “"xenografts"”.
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Tumour ecology of breast cancer patient-derived xenografts
… pre-clinical models, patient-derived tumour xenografts (PDTXs) have been largely excluded from ecological descriptions due to the absence of a human TME and to the immune-compromised status of the mouse host. Evidence however suggests that PDTXs might be good candidates for ecosystem analyses …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… studies have relied for the most part on xenografts derived from commercially available immortalized GBM cell lines. These cell lines poorly mimic patient tumors in vivo and thus do not adequately translate into the clinical setting. Glioma stem cells (GSCs) rectify this shortcoming by …
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An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
… the use of breast cancer patient-derived xenografts (PDXs) in PAI, to begin to answer the aforementioned questions in clinically-relevant models. However, whether PDXs are good vascular models themselves remains unknown. This thesis conducts a careful evaluation of whether vascular …
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Molecular Characterization and Inhibition of Antibodies Elicited Against Galactosyltransferase Knockout Pig Xenografts
… islet xenotransplantation; although all xenografts are likely susceptible to antibody-mediated damage. The purpose of this dissertation is twofold: 1) to provide further molecular characterization of the elicited antibodies which mediate rejection of porcine xenografts, and 2) to identify …
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… and acetate metabolism in patient-derived xenografts (PDX) of glioblastoma in mice and rats respectively. Using 2H-labelled glucose, I showed that despite exhibiting the same concentration of glucose within the tumour, glycolytic PDX subtypes produced more labelled lactate and mitochondrial …
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Understanding Radiation Resistance in Head and Neck Tumor Xenografts Using Diffuse Reflectance and Raman Spectroscopy
… and -sensitive tumors. We established tumor xenografts from two human head and neck cancer cell lines in mice which were treated with 4 doses of 2 Gy twice weekly for two weeks. We observed greater rate of reoxygenation in radiation-resistant tumors which was accompanied with greater content …
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An analysis of the periodicity of the cell cycle and apoptotic regulatory proteins in prostate xenografts using anova and cosinor methods
Circadian rhythms have been found in both plants and animals, in normal tissues as well as in most tumors and human cancers. By following these rhythms in healthy and cancerous tissue, it has been possible to find optimal times to deliver a dose of drug, such that efficacy is maximized and toxicity …
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Modelling RANBP2-ALK-rearranged Epithelioid Inflammatory Myofibroblastic Sarcoma
… models. Survival extension in the eIMS diagnosis xenografts compared to the relapse xenografts indicated the relapse model was less sensitive to ALK inhibition with crizotinib or ceritinib in vivo. However, this was not reflected by in vitro assays. Therefore, in vivo studies were used for the …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
… patient biopsies. Continuous passaging of ten xenografts has also been achieved. Immunophenotypic analysis showed only minor changes in cell surface markers after passage in mice. Leukaemia dissemination in murine bone marrow, liver, spleen and blood was consistent with the human disease. The …
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T-Cell Treatments For Solid and Hematological Tumors
… superior to ROR1RCD28 in clearance of leukemia xenografts <em>in vivo</em>. The second specific aim focused on generating bi-specific CD19-specific CAR<sup>+</sup> gamma/delta T cells with polyclonal TCRgamma/delta repertoire on CD19<sup>+</sup> artificial antigen presenting cells (aAPC). …
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Development of animal models in pediatric cancer
… the study designed to create human leukemia xenografts in immunodeficient mice. This would provide an important tool to understand various aspects of leukemia disease origin and subsequent progression while identifying and evaluating novel therapeutic strategies. The disease models developed …
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Role of DNA repair protein ERCC1 in skin cancer
… cells were xenografted into nude mice the xenografts grew rapidly. Cisplatin treatment caused an initial shrinkage of the tumours, but re-growth rapidly followed. Cells re-isolated into culture from cisplatin treated xenografts had significantly higher levels of ERCC1 protein than either …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… and trastuzumab-resistant/T-DM1-resistant xenografts in vivo including complete remissions. In Chapter 4 (Ketchemen et al. Clin Cancer Res, accepted for publication), we developed and evaluated the effectiveness of antibody-drug radioconjugate [225Ac]Ac-Macropa-trastuzumab-PEG6-DM1 against …
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The evaluation of targeted radionuclide therapies and radio sensitising agents in malignant melanoma
… whether malignant melanoma cell lines and xenografts can berendered susceptible to [131I]MIBG radionuclide therapy via transfection invitro with noradrenaline transporter (NAT) and via gene delivery in vivo withthe HSV1716/NAT vector. • To screen novel DNA repair and IKKβ Inhibitors in …
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
… reduced the proliferation of MCF-7 cell xenografts compared to controls, confirming the use of this model for MCF-7 cell xenografts. In contrast, MDA-MB-231 xenografts did not respond to the same concentrations of PTX or mertansine. Here, we developed an optimized assay and quantitative …
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Biokompatibilitätsuntersuchung von Conduits für den Pulmonalklappenersatz
… der drei Conduit-Typen zeigte sich in den Xenografts, insbesondere im porcinen Gewebe, die stärkste Entzündungsreaktion.Abhängig von der Implantationszeit wiesen die Conduits degenerative Veränderungen in Form von Kalkablagerungen auf. Das porcine Gewebe war am stärksten von Verkalkung …
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Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… in intracranial (ICr) vs. subcutaneous (SQ) xenografts of 4 different human melanoma cell lines. Increased OXPHOS in the ICr xenografts was confirmed by direct metabolite analysis and [U-<sup>13</sup>C]-glucose tracing analysis. Together, these studies indicate that the brain TME mediates …
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