Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"xenoestrogens"”.
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Chemical Mixtures of Xenoestrogens and Their Metabolites Alter Estradiol-Induced Non-Genomic Signaling
BACKGROUND: Xenoestrogens (XEs) pose a threat to human health by disrupting natural responses of physiologic estrogens. Bisphenol-A (BPA), a plastics monomer, is potently estrogenic via non-genomic signaling; however, bisphenol-S (BPS), a BPA substitute, has unknown endocrine actions. Nonylphenol …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
… receptors in males. In addition, exposure to xenoestrogens, or environmental compounds that have anti-estrogenic qualities, is increasing in industrial countries, but the impact of these compounds on skeletal health in males and females remains unknown. In this dissertation, we used animal …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… Similarly, embryonic exposure to reference xenoestrogens - genistein and bisphenol-A (BPA) - with known affinity to human GPER resulted in concentration-dependent effects (albeit with lower potency than G-1) on the developing cardiovascular system. In order to begin revealing mechanisms of …
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The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells
… and late prostate cancer cells. Then several xenoestrogens (XEs) were evaluated for their ability to increase or decrease prostate cancer cell numbers. Coumesterol and genistein unexpectedly stimulated prostate cancer cell growth, while resveratrol minimally increased cell numbers in both …
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The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… chemicals (EDCs) are ubiquitous and often act as xenoestrogens with the ability to disrupt estrogen signaling through differential binding to the various estrogen receptors. Exposure to these xenoestrogens has led to detrimental effects on male reproduction. In fish, observed effects include sex …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
… leiomyoma. Based on this, we hypothesized that xenoestrogens, including genistein (GEN) and bisphenol A (BPA), reprogram estrogen-responsive gene expression in the myometrium and promote the development of uterine leiomyoma. We proposed the mechanism that is responsible for the developmental …
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Type II Estrogen Binding-Site Agonist: The Synthesis and Biological Evaluation of the Enantiomers of Methyl-Para-Hydroxyphenyllactate (MeHPLA)
… was compared to a group of compounds known as xenoestrogens. MeHPLA, phytoestrogens, and xenoestrogens have the ability to stimulate, inhibit, or compromise normal or malignant cells with in the reproductive tract.</p>
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… BDDA) and natural (i.e., genistein and daidzein) xenoestrogens in the protection against obesity-related pathologies. Bisdehydrodoisynolic acid (BDDA) reduced weight gain and adiposity, as well as improved lipid homeostasis in obese rodents. Alternatively, phytoestrogens, such as genistein and …
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Open source estrogen : from biomolecules to biopolitics... hormones with institutional biopower!
… deeply at stake, endocrine disruptors termed 'xenoestrogens' pervade our environments due to petrochemical agro-industrial and pharmaceutical forces. These xeno-molecules change the morphology of our bodies and bodies of non-human species, evidencing a malleability inherent to nature but alien …
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Steroid hormone regulation of fetal mouse oocyte development
… (P4) or E2 mimicking chemicals known as xenoestrogens such as Diethylstilbestrol (DES) and Bisphenol-A (BPA) delay cyst breakdown and follicle formation. The overall goal of this dissertation project is centered on the pivotal question: "What is the source of steroid hormone signaling and …
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A study on endocrine disrupters in the environment through the microarray technology
… activity of various compounds, described as xenoestrogens, is the major part of this debate. Humans beings are exposed to these substances from different environmental contaminations ranging from conscious intake of estrogenic substances, as in contraception or in hormone replace therapy …
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Molecular docking and geographical information systems as tools to assess the potential impact of veterinary medicines on non-target organisms and the environment
… synthetic oestrogen ethinylestradiol, two known xenoestrogens dichlorodiphenyltrichloroethane (DDT) and bisphenol A (BPA), the antioestrogen breast cancer treatment tamoxifen and 15 VMs using Auto Dock 4. Based on the results of this work, four VMs were identified as being possible xenoestrogens …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and o¡¯,p¡¯-dichlorodiphenylethylene (DDE)], plastics manufacturing by-products/detergents (nonylphenol, bisphenol A), and the synthetic estrogen DES for effects on DAT …
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Measurement and risk assessment of endocrine disruptors present in sport supplements
… and synthetic estrogens (endogenoushormones and xenoestrogens). The exposure and risks connected with these two groups of estrogenic compounds were assessed separately (Chapter 5). Subsequently,the influence of genistein, a phytoestrogen most commonly present in food, on IVAbstractendogenous …
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Influence of Insulin, Insulin-Like Growth Factor I and Sex Steroids On the Regulation of the Vitellogenin Receptor In Developing Oocytes of Largemouth Bass (Micropterus Salmoides)
… <italic>vtgr</italic> as a potential target of xenoestrogens which brings to light the involvement of this gene in effects imparted by these chemicals.</p>
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SYNTHESES AND ESTROGENICITY STUDY OF DIETHYLSTILBESTROL AND BISPHENOL-A ANALOGS AS POTENTIAL REPLACEMENT FOR BISPHENOL-A AND INVESTIGATION ON NOVEL REACTIONS INDUCED BY IODANE/QUATERNARY AMMONIUM HALIDES
Dynamic isomerization of diethylstilbestrol (DES) makes it difficult to ascertain the active estrogen between its E and Z isomers. An indirect approach has been used in this project to identify the active estrogen. Methoxylated E- and Z-DES (13 and 14) and 9,10-diethylphenanthrene-3,6-diol (15), a …
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Beurteilung von Phyto- und Xenoöstrogenen am Beispiel ausgewählter Substanzen
Bei Daidzein und Bisphenol A handelt es sich um zwei Vertreter einer Klasse von Stoffen, die als „Umwelthormone“ (engl. endocrine disrupter) bezeichnet werden. Aus der Gruppe der Phytoöstrogene wurde Daidzein als wichtiger Vertreter, der in hohen Konzentrationen in vielen Nutzpflanzen und …
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Assessment of the Efficacy of a Constructed Wetland to Reduce or Remove Wastewater Effluent Estrogenicity and Toxicity Using Biomarkers in Male Fathead Minnows (Pimephales Promelas Rafinesque, 1820)
Vitellogenin in Pimephales promelas was used to assess estrogenicity of a local municipal effluent. Vitellogenin induction in male P. promelas increased in frequency and magnitude with increased exposure duration and was greater ("=0.05) than controls after 2 and 3 weeks of exposure. The level of …