Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"xenobiotic"”.
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Xenobiotic Metabolism Genes and Clubfoot
… marginal interactions were found for other xenobiotic genes and these interactions may play a contributory role in clubfoot. Importantly, for CYP1A2, significant maternal (p=0.03; RR=1.24; 95% CI: 1.04-1.44) and fetal (p=0.01; RR=1.33; 95% CI: 1.13-1.54) genotypic effects were identified …
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Porcine model of xenobiotic metabolism
A xenobiotic is a foreign chemical substance found in the environment. The body removes xenobiotics by xenobiotic metabolism. Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination, and detoxification of xenobiotics introduced into the body. Orphan nuclear receptors play …
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Molecular Similarity and Xenobiotic Metabolism
… a data-mining approach for predicting sites of xenobiotic metabolism has been developed. The algorithm is based on a statistical analysis of the occurrences of atom centred circular fingerprints in both substrates and metabolites. This approach has undergone extensive evaluation and been shown …
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
… have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates cardiovascular disease including myocardial infarction. The impact of particulate matter on cardiovascular health has served as a backdrop concern raising questions regarding the potential …
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Xenobiotic metabolism and zebrafish (danio rerio) larvae
… for the characterisation of the metabolism of xenobiotics in zebrafish larvae, due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were demonstrated to be …
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Treatment studies on a xenobiotic containing industrial effluent
The aim of this project was to assess treatment processes for an effluent generated from the manufacture of a mixture of dinitroethylbenzene and trinitroethylbenzene, known as K10.
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Xenobiotic metabolism and mutation in diploid human lymphoblasts
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1982
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Investigations on the Reaction Mechanism of Xenobiotic Reductase A
Xenobiotic reductase A (XenA) from Pseudomonas putida 86 is a member of the Old Yellow Enzyme family of FMN containing enzymes. It catalyzes the NADH/NADPH dependent reduction of various substrates, including 2-cyclohexenone, coumarin, 7- and 8-hydroxycoumarin in a two-step mechanism consisting of …
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Functional and Molecular Aspects of Xenobiotic Transport in Choroid Plexus
… CSF, but also transports potentially toxic xenobiotics and waste products of neural metabolism to the blood for eventual clearance in kidney and liver. For several decades it has been known that the CP is actively involved in removing organic anions and other organic compounds from the …
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Xenobiotic detoxification in the navel orangeworm Amyelois transitella (Lepidoptera: Pyralidae)
… by its metabolic capacity to detoxify xenobiotics. Using Illumina RNA sequencing, I characterized the cytochrome P450 genes transcribed in the midgut of the caterpillar. A total of 319 million paired-end reads were sequenced from larval midgut tissue, and these were assembled de novo …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
Xenobiotics are plant derived compounds metabolized by phase I and II liver enzymes. Phase I enzymes increase, and phase II enzymes decrease, xenobiotic toxicity. Xenobiotics considered were ergotamine, associated with fescue toxicosis, and sulforaphane, a phase II inducer. Hypothesized responses …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
… factors for absorption and disposition of xenobiotics. These studies investigated the effects of potential modulators of Pgp and/or membrane function on the disposition, bioavailability and bioaccumulation of environmentally relevant pharmaceuticals, tetracycline and ivermectin, and the …
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Interactions Among Steroid and Xenobiotic Response Cascades in the Regulation of CYP6B1
In support of this idea, treatment with the synthetic aryl hydrocarbon benzo[alpha]pyrene or the plant signaling molecule salicylic acid in combination with xanthotoxin resulted in in vitro transcription that was similar to treatment with either chemical alone, suggesting that the response cascades …
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Investigating the Functional Response of a Subsurface Biofilm Community to Xenobiotic Stress
Biologically-mediated subsurface remediation by biofilm communities is a poorly understood process that is spatially and temporally dynamic. Two microbial responses, catabolism and the stress response glutathione-gated potassium efflux (GGKE), to benzene, pentachlorophenol (PCP), or Cd exposure …
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Xenobiotic metabolism and markers of genotoxicity in regulatory non-vertebrate ecotoxicological test species
… Methods were also developed to allow the xenobiotic biotransformation capability (via 7-ethoxyresorufin-O-deethylase or EROD activity) of both organisms to be measured. C. reinhardtii and D. magna possessed low, but measurable, basal EROD activity (0.03 pmol/minute/106 algal cells and 7 …
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Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
… cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, inflammation, proliferation, and survival. Understanding the molecular mechanisms of xenobiotic-induced NRF2 …
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DISCLOSING THE ROLE OF ROOT EXUDATES IN MODULATING THE INTERACTION BETWEEN PLANT AND XENOBIOTIC DEGRADING BACTERIA
… strategy for the clean-up of recalcitrant xenobiotics like polychlorinated biphenyls (PCBs), contaminants that induce severe phytotoxic effects, as well as posing serious threats to ecosystems and human health. The aim of this PhD thesis was to disclose the role of root exudates …
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Antibiotic resistant and xenobiotic degrading bacteria that shape the microbiota of the vectors Aedes aegypti & Culicoides sonorensis
Vector-borne disease cases have doubled in the United States over the last two decades. The vectors, Aedes aegypti and Culicoides sonorensis, which transmit pathogens that affect humans and animals, are present in the United States, and their geographic distribution continues to grow. The viruses …
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Xenobiotic monooxygenase activity and the response to inducers of cytochrome P-450 during embryonic and larval development in fish
… the presence and inducibility of the xenobiotic monooxygenase system in fish embryos and larvae are described. The ontogeny of benzo(a)pyrene monooxygenase (BPM) activity, and NADPH- and NADH-cytochrome c reductase activities, were followed in microsomes prepared from whole embryos of …
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Understanding the Impact of BCRP and PGP Efflux Transporters on the Disposition of Their Endogenous, Xenobiotic and Dietary Substrates
… transporters in therapeutic resistance of their xenobiotic substrates due to their expression and efflux function at target organs/tissues, especially in brain and intestine, is well established, which has fueled investigation toward identification of their inhibitors. Multiple clinically used …
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