Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"xeno nucleic acids"”.
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Towards Enzymatic Synthesis of Uncharged Xeno Nucleic Acids
… analogues of DNA, referred to collectively as xeno nucleic acids (XNAs), can address some such limitations. The polyanionic backbone of DNA dominates its physicochemical properties and decouples them from its information content. In this thesis, I explore two XNA chemistries with neutrally …
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Encoded synthesis and evolution of clinically approved 2'-modified ribonucleic acids
Xeno-nucleic acids (XNAs) are unnatural nucleic acids with altered sugar, phosphodiester backbone, or nucleobase components. 2'-modified nucleic acid chemistries, such as 2'-O-methyl-RNA (2'OMe-RNA) and 2'-O-2-methoxyethyl-RNA (MOE-RNA), have shown promise in clinical applications due to their …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… advanced chemical modifications, such as Xeno Nucleic Acids (XNAs) and 2-OH modifications, along with specialized delivery systems, including viral vectors and lipid nanoparticles (LNPs), have been introduced. The design of these advanced ligands increasingly relies on computational …