Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"xbp-1"”.
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Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity
… we demonstrate that intestinal expression of XBP-1 is sufficient to overcome PMK-1 dependent larval lethality on a lawn of pathogenic Pseudomonas aeruginosa. Further, we demonstrate that XBP-1 deficiency results in constitutive ER stress even in the absence of pathogenic infection. This …
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Regulation of B lymphocyte terminal differentiation and death by the transcription factor Blimp-1
… (Blimp-1) und X-box-binding protein-1” (XBP-1) sind als Transkriptionsfaktoren unverzichtbar für die terminale Differenzierung von B-Lymphozyten zu Immunglobulin (Ig)-sezernierenden Plasmazellen. Ebenso stellen die unfolded protein response (UPR) und das Spleißen von XBP-1, beides …
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Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development
… In Chapter Two, I show that the IRE-1 -XBP- 1 pathway is activated by infection with the bacterial pathogen Pseudomonas aeruginosa and is essential for larval development in the presence of pathogen. Through genetic analyses, I demonstrate that immune activation is necessary and …
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Genetic analysis of endoplasmic reticulum homeostasis during stress and infection of Caenorhabditis elegans
… Specifically, the most ancient IRE-1/XBP-1 branch of the UPR is required for larval development during immune activation, whether or not pathogen is present. To understand additional mechanisms regulating ER homeostasis in C. elegans, we conducted a forward genetic screen and …
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The degradation of membrane proteins from the mammalian endoplasmic reticulum
… the ATF6-dependent response nor the IREltc-XBP-1-dependent response of the UPR was found to be essential for efficient degradation of TCRc, US2-, or US 11-catalyzed destruction of MHC class I molecules. Interestingly, the ATF6 response, but not the IRElct-XBP-1 response, is essential for …
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Mechanisms of High Glucose-induced Decrease in β-cell Function
… activation of the unfolded protein response (XBP-1 mRNA splicing and phospho-eIF2α levels). This was partially prevented by Tempol. Co-infusion of the chemical chaperone 4-phenylbutyrate with glucose decreased spliced XBP-1 levels, and prevented high glucose-induced β-cell dysfunction in vivo …
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Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells
… a decrease in ATF6 90 kDa protein and transient XBP-1 mRNA splicing. The activation of p38, JNK and ERK MAPK pathways in bisPMB treated WHCO1 cells was also observed. Furthermore siRNA mediated knock-down of CHOP abolished the anti-proliferative effect of bisPMB in WHCO1 cells. However, …
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Exploring the role of the unfolded protein response in C. elegans neurons
… of ER stress. Overexpression of active, spliced XBP-1 (XBP-1s), a transcription factor that acts downstream of the UPRER kinase/endoribonuclease IRE-1, in the nervous system of C. elegans increases the lifespan and healthspan of worms through UPRER induction in the intestine cell …
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The Life of Prion: an investigation into the physiological role of a prion-like protein in the nematode Caenorhabditis elegans
For centuries, the threat of prion disease has plagued populations – whether it be in the form of scrapie ravaging through the sheep populations of Spain in the eighteenth century, fatal familial insomnia afflicting families in Italy, or an outbreak of Creutzfeldt-Jakob disease in the UK triggered …