Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"xCT"”.
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XCT, SEM, and LA-ICP-MS map investigation of chondrule FGRS in CM2 Aguas Zarcas
… microscopy (SEM), X-ray computed tomography (XCT), and laser-ablation inductively coupled plasma mass spectroscopy (LA-ICP-MS) analyses, enabling a novel investigation into early solar system processes, providing insights into FGR formation and trace element patterns across FGR and matrix to …
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Prognostic Significance of Xct Polymorphisms and Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy
… expressed by pancreatic cancer cells. The <em>xCT</em> gene, encoding the cystine-specific xCT protein subunit of x<sub>c</sub><sup>-</sup>, is important in regulating intracellular glutathione (GSH) levels, critical for cancer cell protection against oxidative stress, tumor growth and …
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Extracting Physically Realistic Pore Network Features from XCT Data and Investigating the Impact of Pore Topology on Flow in Porous Media
<p>Synchrotron XCT imaging approaches applied in this study provides crucial information on the impact of image voxel resolution on image based simulation results and the characteristic length scales that can be extracted from XCT image data sets. The methods and results in this work provides a …
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An investigation into the complementary capabilities of X-ray computed tomography and hyperspectral imaging of drill core in geometallurgy
… imaging (HSI) and 3D Xray computed tomography (XCT) have the potential to be incorporated into the machine learning dataset. Hyperspectral imaging is a critical component of continuous drill core scanning in geometallurgy for identifying problematic minerals in downstream mineral processing, …
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GLIOBASTOMA MULTIFORME UTILIZES SYSTEM Xc¯ FOR SURVIVAL UNDER OXIDATIVE STRESS AND PROMOTES CHEMORESISTANCE
… domain catalytic light chain subunit (xCT) that mediates the uptake of L-cystine into the cell, and L-glutamate out of the cell, at a 1:1 ratio. Imported cystine is quickly reduced to L- cysteine, the rate limiting substrate in glutathione (GSH) synthesis. Glutathione is a major …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… inhibition of ESRRA with the inverse agonist XCT-790 significantly reduced Gb3 accumulation in both CLN3 and CLN7 disease models, suggesting that ESRRA may represent a novel therapeutic target for multiple BDs. Transcriptomic analysis revealed that pharmacological inhibition of ESRRA with …
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Image-Based Modeling of Porous Media Using FEM and Lagrangian Particle Tracking
… use high-resolution x-ray computed tomography (XCT) to image two unsaturated rock/fracture/proppant systems under a series of stress levels typical of producing reservoirs: one with shale, one with Berea sandstone. The resulting XCT images were segmented, analyzed for structural and porosity …
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Modulation of System x<sub>c</sub>- Mediated Glutamate Release in Glioblastoma Multiforme via the Extracellular Matrix: The Agony and the Xctasy
… is comprised of a light chain catalytic subunit (xCT) bound to a heavy chain regulatory subunit (4f2hc/CD98) via a disulfide bond. The xCT subunit is responsible for the equimolar exchange of extracellular cystine for intracellular glutamate. Clinical studies have shown areas immediately …
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Three dimensional quantitative textural analysis of nickel sulphide ore using X-ray computed tomography and grey level co-occurrence matrices on drill core
… study, the use of 3D X-ray computed tomography (XCT) is proposed as an innovative solution to non-destructively image the internal structure of drill core. Thereafter, an established, discipline independent two dimensional (2D) image analysis technique known as grey level co-occurrence matrices …
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Temperature dependent dynamic response of open-cell polyurethane foams
… analyzed with X-ray computed micro-tomography (XCT) to investigate microstructure properties pre- and post-mortem. In depth analysis allowed for accurate modeling of the foam storage properties and the rate dependency behavior as a function of temperature. The XCT was used to probe qualitative …
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Petrofabric investigation of the sulfide-rich basal zone of the Duluth Complex
… the magnetic fabric. X-ray computed tomography (XCT) reveals that, where silicate minerals are well-aligned, sulfides form interconnected, net-textured networks along grain boundaries, whereas in rocks with disordered textures, sulfides remain diffuse and disseminated. These integrated results …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… cell line MCF-7, the xc- specific subunit, xCT, mRNA and protein expression were found to decrease following treatment with estradiol. Additionally, estradiol was found to decrease the doubling time of these cells, while sulfasalazine increased the doubling time. Interestingly, it was found …
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Establishing the optimal conditions for rotating arm erosion testing, materials characterisation and computational modelling of wind turbine blade rain erosion
… be fully explored. Sub-surface imagery, through XCT scans, showed that any defects near the surface of a sample can lead to stress concentrations at the damaged area. The XCT imagery also showed that voids near the composite interface did not affect the erosion initiation or location. Subsequent …
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Identifying novel therapeutic targets for seizures and brain cancers
… Xc- cysteine-glutamate exchange transporter (XCT) antagonist sulfasalazine reduced the frequency of seizures. In human studies of TAS, increased levels of glutamate, reduced excitatory amino acid transporter 2 (EAAT2) expression and reduced XCT were associated with greater frequency of TAS. We …
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Untersuchungen zur vollständigen Knochenmineralisation am teilosteotomierten Oberkiefer beim Neuseeländer-Kaninchen
… durch einen quantitativen Computertomographen (XCT 2000, STRATEC Medizintechnik, Pforzheim) bestimmt. Dieser QCT errechnet mit Hilfe eines volumetrischen Modells die Knochendichte in mg /cm3. In der Auswertung ergab sich für die Gruppe ohne Trepanationsbohrung ein signifikant höherer Wert der …
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Quantitative Knochendichtemessungen an der Scapula als Basis für dreidimensionale Finite-Elemente-Modelle
… fixiert und mit einem pQCT-Scanner (Stratec XCT 2000)untersucht. Der pQCT-Scanner erlaubt eine selektive, volumenbezogene Bestimmung der kortikalen und spongiösen Bereiche des Knochens. 35 definierte Schnittbilder pro Scapula wurden anschließend auf einem UNIX-System der Firma HERMES in …
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Procedural analyses of image-based and multiscale investigations of materials
… from microfocus x-ray computed tomography (XCT) data. These geometries are to be used as initial conditions in image-based physics simulations. A software package called Segmentflow was developed to contain the workflow functions. Segmentflow is controlled by an input file which specifies …
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Modulating System xc- Activity As A Treatment For Epilepsy
… (S-4-CPG) or antisense xCT, resulted in a 60% reduction in extrasynaptic glutamate in the nucleus accumbens. Additionally, investigations in tumor-associated epilepsy revealed that overexpression of SXC seen in glioblastomas lead to higher levels of peritumoral glutamate, …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… null for the substrate-specific light chain, xCT. Moreover, in most tissues, including the CNS, cystine import through Sxc- is necessary for the synthesis and maintenance of glutathione (GSH) levels. Given that either a reduction in ambient glutamate levels and/or a redox imbalance involving …
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Bestimmung der apparenten Knochendichte am Kaninchenkiefermodell mittels der Peripheren Quantitativen Computertomographie
… sich die Hydroxylapatitdichte bestimmen lässt (XCT 2000, STRATEC Medizintechnik, Pforzheim) zum Einsatz. Die quantitative Computertomographie ermöglicht , mit Hilfe eines volumetrischen Modells die Knochendichte in mg/cm3 zu berechnen, wobei wahlweise zwischen apparenter und vollständig …
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