Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"x-ray crystallographic structures"”.
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Hydrogen Bonded Liquid Crystals from Fluorophenols and Alkoxystilbazoles
… stilbazoles and 3- and 4-nitrophenol. Nine X-ray crystallographic structures of the 4-octyoxy-4’-stilbazole complexed with fluorophenols were also obtained. Eight of the complexes crystallised in the space group, with a back-to-back dimer motif, while the complex of 4-fluorophenol crystallised …
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A Molecular Characterization of Human General Transcription Factor IID
… control as a direct target for a diverse array of gene-specific regulatory factors and as the only template-bound class II initiation factor. The work described in this thesis concerns itself with the molecular characterization of this transcription initiation factor, starting with the …
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Design, Structure, And Action Of An Artificial Photosynthetic Reaction Center
… a long-lived charge separated state. X-ray crystallographic structures of MZH3 are solved in complex with heme B, a synthetic zinc porphyrin, and metal ion cofactors. Despite sharing low sequence identity with natural proteins, MZH3 exhibits significant structural similarity to …
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The Choreography of Base Excision Repair
… beta (Pol β). First, we report seven X-ray crystallographic structures that reveal how APE1 influences the conformations of a variety of different mismatched base pairs. We show that the conformation of DNA mismatches bound by APE1 differ from the conformation of similar mismatches bound …
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A molecular dynamics study of hormone receptor-DNA binding
… hormone receptor subfamily based on available X-ray crystallographic structures of a glucocorticoid receptor DNA binding domain dimer/DNA complex and an estrogen receptor DNA binding domain dimer/DNA complex. Each set of simulations consisted of at least three individual simulations: the dimer …
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Electron gating and mechanism of proton exit in quinol oxidation in cyt bc1 complex from R. sphaeroides
… c1 is now well established on the basis of the X-ray crystallographic structures and mutational studies, most previous discussions of mechanism have been in the context of a monomeric scheme. We have tested for inter-monomer electron transfer by assaying quinol turnover through reduction of …
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Targeting isoprenoid biosynthesis for drug discovery
… In chapter 2, I report the discovery and x-ray crystallographic structures of 10 structurally diverse compounds (benzoic/diketo/phosphonic acids, bisamidine, and bisamine) that inhibit UPPS, an essential enzyme involved in cell wall biosynthesis. The inhibitors bind to one or more of the …
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Structural and biochemical studies of plant inositol phosphate kinases
… investigated as a novel ITPK family member. X-ray crystallographic structures of AtIPK1XHis in complex with myo-inositol hexakisphosphate, myo-inositol 1,3,4,5,6-pentakisphosphate, neo- and D-chiro-inositol pentakisphosphate were collected to aid understanding of substrate use. Structural data …