Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"wound repair"”.
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Design, characterization, and reinforcement of mineralized collagen-glycosaminoglycan scaffolds for orthopedic wound repair
… (2) guiding and supporting cellular specific repair specific to orthopedic defects; (3) demonstrate mechanical competence for surgical implantation and subsequent loading during function. This work outlines the development of a collagen-glycosaminoglycan platform that satisfies these …
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Insights into the mechanisms of wound repair and the role of TP508 in tissue regeneration
… mechanisms in place to rapidly and effectively repair damaged tissues. The goal of this dissertation work was two-fold. First, this work sought to gain insights into the mediators of inflammatory-induced tissue injury using the protein tyrosine phosphatase PTP-PEST as a potential regulator of …
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The effects of TGF-β on the behaviour of a keratinocyte cell line: implications in wound repair
… isoforms are important signalling molecules in wound repair in the skin. Transforming growth factor β3 (TGF-β3) has been implicated in scarless healing. In both animal and human models the application of exogenous TGF-β3 causes a reduction in the inflammatory response and improves the …
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Stochasticity and order: studies of keratinocyte proliferation
… a quiescent stem cell population activated upon wounding or genetic mutation. To study the proliferative behaviour of human keratinocytes, I used live imaging in vitro at single cell resolution. This shows two modes of proliferation: Type 1 cell division is stochastic with equal odds of …
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Regulation of airway epithelial cell migration by the cystic fibrosis transmembrane conductance regulator.
… of damage to the epithelial barrier followed by wound repair, eventually resulting in airway remodeling and ultimately respiratory failure. It has recently been demonstrated that the loss of CFTR function impairs epithelial restitution in the absence of infection. This suggests the CFTR plays a …
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Synthesis and Characterization of Novel Polyester Scaffolds from Sugarcane Industry By-products for Use in Skin and Bone Tissue Engineering
… For skin tissue engineering, especially wound repair, thin film polyester scaffolds laden with hASC were grown in stromal medium supplemented with basic fibroblast growth factor (bFGF). Based on the amount of collagen synthesized and DNA quantification data it was concluded that the …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
… of the condition. Inflammatory responses and wound repair by HPMECs and SAECs were attenuated in HCA, demonstrating its beneficial, but also potentially detrimental effects. This is the first time that the effects of HCA on the reparative response of HPMECs and SAECs has been demonstrated in …
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
<p>Impaired wound healing can lead to excessive scarring, dehiscence, chronic ulcers, and infection, which have adverse impact on the quality of life and pose a significant economic burden on the health care system. Thus, new therapeutic approaches are critically important. Dermal fibroblasts are …
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Development of a novel co-culture based in vitro model system to study the wound healing process
Drug development research on wound repair is challenging and inefficient due to the complex nature of wound healing and scarring processes and the limitations of available in vitro or in vivo models used for preclinical drug testing. Many patients who undergo elective back surgery develop …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient¿s life is arthritis. Research on cartilage cell/tissue engineering will help patients to …
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Cell and tissue engineering of articular cartilage via regulation and alignment of primary chondrocyte using manipulated transforming growth factors and ECM proteins. Effect of transforming growth factor-beta (TGF-¿1, 2 and 3) on the biological regulation and wound repair of chondrocyte monolayers with and without presence of ECM proteins.
… the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. One of the common forms of articular cartilage disease which has a huge impact on patient¿s life is arthritis. Research on cartilage cell/tissue engineering will help patients to …
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The Tumor-Suppressive Properties of Neural Stem Cells
… the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted into GBM tumors showed decreased tumor growth and increased animal survival in mice; however, the mechanisms underlying these anti-tumor properties of NSCs are …
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DNA Methylation Landscape of the Fibrinogen Gene Cluster in the Equine Embryo
… its involvement in the coagulation cascade and wound repair. The aim of this MSc project was to contribute to the characterization of conceptus-derived fibrinogen at the time of fixation. We confirmed early embryo expression in the absence of hepatic activity, as well as describe expression by …
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Transcriptional Regulation of Profilin Is Required For Drosophila Larval Wound Closure
<p>Injury is an inevitable part of life, making wound healing essential for survival. In postembryonic skin, wound closure requires that epidermal cells recognize the presence of a gap and change their behavior to migrate across it. In Drosophila larvae, wound closure requires two signaling …
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Incorporation of Tetracycline Hydrochloride into Electrospun Fibrinogen: a study of mechanical properties and time release
… an early scaffold for cell migration for either wound repair or tissue engineering. The addition of antibiotic into such a dressing/scaffold could prevent infection during healing/incorporation. The goal of this study was to determine any effect that the addition of the antibiotic tetracycline …
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Interactions of Fibroblast with Cytotoxic and Invasive Strains of Pseudomonas aeruginosa on ECM Mimicking Fibers
… (ECM) and secreting a new ECM which aids in wound repair and supports the migration of immune cells. Pseudomonas aeruginosa is an opportunistic pathogen commonly associated with health-care infections (HCAIs) due to its ability to take advantage of immunocompromised hosts. However, little …
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The role of sphingosine kinases and SKAM1 in cutaneous wound healing
… processes that are known to be fundamental to wound healing. The role of SK and S1P in cancer and other diseases including asthma, hypertension, atherosclerosis and allergy are well established. Notably, however, the direct role of the SKs and S1P in wound healing has not been previously …
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