Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"wound contraction"”.
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Effects of degradation rate and crosslink density of artificial skin on wound contraction
Thesis: M.S., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1986
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Negative Pressure Wound Therapy - Mechanisms of Action and Protecting Exposed Blood Vessels in the Wound Bed
… severe complications and bleeding when used in wounds with exposed blood vessels. The aims of this work were to investigate the mechanisms of action of NPWT and to explore the possibility of using thin plastic discs to protect exposed blood vessels in the wound bed during NPWT. Three different …
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Computational Modeling and Simulation Study of Dermal Wound Healing Proliferative Phase
Dermal wound healing proliferative phase is a complicated physiological process in which many growth factors, cell types and matrix components participate. The process must be well coordinated to restore the structural and functional integrity of tissue injured. Many disorders interrupting healing …
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Topical Antimicrobial and Bandaging Effects on Equine Distal Limb Wound Healing
… increase rates of healing of equine distal limb wounds that heal by second intention. Second, to determine the effect of bandaging with these topical antimicrobials. Six healthy adult horses were used to create thirty-six, 2.5 cm2 standardized full-thickness metacarpal/tarsal skin wounds. Each …
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Finite Element Analysis on the skin properties affecting wound closure
… on the properties of skin that affect skin wound closure and scar formation. It begins with an in depth literature review of mammalian studies and computer simulations of skin wounds, providing a better understanding of the mechanics of skin during wound healing. Details are then provided …
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Developing quantitative models for contraction at wound edges using finite element analysis
… to develop a quantitative tool for studying contraction at wound edges. Two models showing contraction at the edges of a cylindrical liver wound were employed. The first model assumed that contractile cells applied forces to the wound only at the top and bottom surfaces of the liver; the …
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Dreidimensionales epidermis-ähnliches Wachstum humaner mesenchymaler Stammzellen auf dermalen Äquivalenten : Einfluss der experimentellen Kulturbedingungen auf Differenzierung, Migration und funktionelles Verhalten
… results indicate that hMSC might contribute to wound healing processes by extracellular matrix reorganization and wound contraction but not by differentiation into keratinocytes.
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Characterisation of Cutaneous Wound Healing Process in Naked Mole Rats
… other rodents, not much is known about their wound healing process. To investigate that, full-thickness wounds were created in the back skin of naked mole rats. Our initial data confirmed that wound closure in NMR skin was achieved primarily by reepithelialization and granulation tissue …
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Characterisation of Cutaneous Wound Healing Process in Naked Mole Rats
… other rodents, not much is known about their wound healing process. To investigate that, full-thickness wounds were created in the back skin of naked mole rats. Our initial data confirmed that wound closure in NMR skin was achieved primarily by reepithelialization and granulation tissue …
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The effect of Stromal cell Derived Factor-1 (SDF-1) and collagen-GAG (Glycosaminoglycan) scaffold on skin wound healing
Wound healing is an intricate biological process requiring the appropriate balance of matrix and growth factors. Apart from causing physical deformity, adult wound healing results in the formation of scar tissue, which can hinder functionality and mobility due to excessive wound contraction. Wound …
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Effect of treadmill exercise on cutaneous wound healing in obese mice
Impaired wound healing induced by obesity is a major health care concern. Non-healing wounds account for greater than $25 billion in annual health care costs in the United States alone. Thus, therapies to speed healing are of major interest, and research into a number of therapeutic wound …
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The effects of TGF-β on the behaviour of a keratinocyte cell line: implications in wound repair
… isoforms are important signalling molecules in wound repair in the skin. Transforming growth factor β3 (TGF-β3) has been implicated in scarless healing. In both animal and human models the application of exogenous TGF-β3 causes a reduction in the inflammatory response and improves the …
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Molecular and functional differentiation of murine macrophage subtypes
… remodeling, and should facilitate scar-free wound healing. In contrast, BM macrophages are thought to represent a macrophage subtype predominantly mediating inflammation related immune responses and antigen presentation. ES macrophages were to be molecularly and functionally characterized in …
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The role of sphingosine kinases and SKAM1 in cutaneous wound healing
… differentiation, migration, smooth muscle cell contraction, inflammation, cytoskeleton reorganisation and angiogenesis, mainly via the engagement of S1P to a family of five S1P-specific G protein-coupled receptors (GPCRs). As such, the SKs and S1P are involved in regulating a plethora of …
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Negative Pressure Wound Therapy - Effects on Sternotomy Wounds and the Intrathoracic Organs
Negative pressure wound therapy (NPWT) has been widely adopted for the treatment of deep sternal wound infections due to its excellent clinical outcome. However, the mechanisms of action and effects on hemodynamics have not been thoroughly elucidated. The aims of the work presented in this thesis …