Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"worm-like chain model"”.
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STUDYING THE INTERACTION OF CANCER AND THROMBOSIS THERAPEUTICS WITH PROTEIN AND DNA
… We have AFM and simulations, based on the worm-like chain model (WLC), to study DNA conformational changes due to its interaction with two cancer drugs, cisplatin and Pt-Acramtu. We found that cisplatin induces a 36º bend angle for a cisplatin-GG adduct and 0 - 19º for a cisplatin-AG …
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Unexpected mechanical properties of nucleic acids
… competing pictures of DNA bending by providing a model that can explain the novel results without discrediting old experiments and the widely-accepted worm-like chain model. Another factor that influences both molecular geometry as well as mechanical properties is the ionic atmosphere surrounding …
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Towards Models Mesoscale Chromatin Structure and Radiative DNA Damage via Computational Simulation
… higher orders of chromosome organization, and is likely involved in transcriptional control. However, the heterogeneity of nucleosome positioning and histone variant composition in cells as well as the high density of chromatin <em>in situ</em> make the mesoscale difficult to study. Recent …
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Nanoscale studies of CVD graphene and poly(3-hexylthiophene) thin films.
… free approach for efficient self-organization of chains via π-π interactions. I propose the use of two methods for quantifying the persistence length of the polymer chains: edge-detection based Hough transform and the worm-like chain model. By optimizing the graphene electrode and the polymer …
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Force-response statistics of semiflexible polymers
… and the formation of histone-DNA complexes. The worm-like chain theory is a polymer-physics-based model and has been successfully applied to predict force-extension relations, bond correlations, and dynamics of semiflexible biopolymers. Despite these successes, the effects of non-uniform forces …
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Single molecule fluorescence studies of biomolecular interactions
… 67 and 106 bps, deviating significantly from the worm-like chain model. We propose that many biologically significant protein-DNA interactions that involve looping and bending of DNA below 100 bp likely use this intrinsic bendability of DNA. One of the critical aspects of a virus life cycle is …
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Mineral-Microbe Interactions Probed in Force, Energy, and Distance Nanospace
… in the force curves, analyzed with the worm-like chain model of protein unfolding, suggest that the bacterium recognizes the mineral surface such that a 150 kDa putative, iron reductase is quickly mobilized within the outer membrane of S. oneidensis and specifically interacts with the …
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Tension Propagation Along Tip-Link Cadherins: Regulation and Implications for the Auditory System
… of auditory stimuli. In the present work, we model the tip link as a worm-like chain and evaluate its fast dynamic response using theoretical and numerical calculations. Our analysis uncovers frequencies at which the tip link exhibits viscoelastic behavior, and we evaluate how this behavior …
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Development of Methods for Structure and Function Determination in Living and Fixated Cells on the Single-Molecule Level Based on Coincidence Analysis and Spectrally-Resolved Fluorescence Lifetime Imaging Microscopy [SFLIM]
… to groundbreaking results in the recent years, like the mapping of the human genome. The consequence of the rising knowledge of biological structures and mechanism is that gradually smaller and infrequent units, which are not resolvable by common methods anymore, are subject to investigation. In …