Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"wnt11"”.
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Regulation of Zebrafish Gastrulation Movements by slb/wnt11
… Recent studies have identified silberblick (slb/wnt11) as a key molecule that regulates gastrulation movement through a conserved pathway, which shares significant similarity with a signalling pathway that establishes epithelial planar cell polarity (PCP) in Drosophila (Heisenberg et al., 2000; …
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Local Wnt11 Signalling and its role in coordinating cell behaviour in zebrafish embryos
Wnt11 is a key signalling molecule that regulates cell polarity/migration during vertebrate development and also promotes the invasive behaviour of adult cancer cells. It is therefore essential to understand the mechanisms by which Wnt11 signalling regulates cell behaviour. The process of …
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Identification of proteins controlling gastrulation movements by a proteomic approach in zebrafish
… strategies: (1) Based on the notion that Wnt11 regulates cell movement and morphology during gastrulation independent of transcriptional regulation, I performed a screen aimed at the identification of proteins phosphorylated upon Wnt11 signalling. To regulate Wnt11 expression tightly, I …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
… modulates both <em>Siamois</em> and <em>Wnt11</em> gene expression in the expected manner based upon the resulting latered levels of p120-catenin. I determined that Dyrk expression rescues Kaiso depletion effects (gastrulation failure; increased endogenous Wnt11 expression), and vice …
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Investigating WNT signalling in the lung
… ATMIN single and double knockdowns, as well as WNT11 and PKD2 single and double knockdowns, were performed in A549 cells to assess the interrelationship between these genes and to determine their functional effects in lung epithelial cells. Several cellular functions, including apoptosis, …
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CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… of the non-canonical Wnts (ncWnts), Wnt5 and Wnt11, during zebrafish development leading to a shorter and broader body axis with defects in elongation during segmentation resulting in undulation of the notochord. While it is clear ncWnts are necessary for C&E, many of the downstream effectors …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
… decreased gradually as follow passages, except Wnt11. Especially, gene expression of sFRP1, an antagonist of Wnt signaling, was also decreased. To confirm whether sFRP1 affects proliferation of hMSC, MSC/sFRP1 and MSC/shsFRP1 were made and then cell proliferation was measured. Growth kinetics …
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Gene Discovery In Nonsyndromic Cleft Lip With Or Without Cleft Palate
… 0.009≤p<0.05), Wnt3A (4 SNPs, 0.001≤p≤0.005), Wnt11 (2 SNPs, 0.001≤p≤0.01) and CRISPLD2 (4 SNPs, 0.001≤p<0.05). The most interesting findings were for CRISPLD2. This gene is expressed in the fused mouse palate at E17.5. In zebrafish, crispld2 localized to the craniofacial region by one day post …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… wnt3a, wnt4, wnt5a, wnt5b, wnt6, wnt7b, wnt10a, wnt11, and wnt11b) are expressed in the cornea epithelium, demonstrating that this tissue is transcribing many of the components of the Wnt signaling pathway. When compared to flank epithelium, which is lens regeneration incompetent, only wnt11 and …
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Investigating the evolution and function of Wnt ligands
… spiders and scorpions, duplications of Wnt7 and Wnt11 were observed. Taking some of the results from this broad evolutionary analysis, it would be interesting to understand on a finer scale how the expression or function of Wnt genes is conserved throughout more closely related species. Here, …