Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"wnt pathway"”.
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway
… to this subpopulation of tumour cells. Wnt activity and β-catenin signalling have been associated with different types of cancer and microarray data from our laboratory highlighted upregulation of members of the Wnt pathway in primary prostate cancer stem cells. Therefore, the aim of …
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Specific forms of TCF7L2 protein define the Wnt pathway dependent genetic program
… transcription factor is a critical regulator of Wnt pathway-dependent gene expression in the intestinal epithelia. Mutations in TCF7L2 have been previously reported in colorectal cancer, however their functional impact on tumour biology has not been investigated. The present work has determined …
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The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second …
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Eukaryotic protein mimicry as an infection strategy for Ehrlichia chaffeensis
… reported that E. ch. activates canonical Wnt signaling in monocytes to promote bacterial uptake and intracellular survival and that TRP120 was involved in this activation event. To identify the specific mechanism of pathway activation, we hypothesized that TRP120 is a Wnt signaling ligand …
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The canonical Wnt signaling pathway affects regeneration of mechanosensory hair cells in Danio Rerio
… Research using pharmacological modulators of the Wnt pathway has suggested that the Wnt pathway potentially plays a role in lateral line hair cell regeneration. In this current study, we examine the role of the Wnt signaling pathway in hair cell regeneration by employing Wnt pathway mutant …
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Engineering Tools to Promote and Characterize Wnt-Mediated Stem Cell Differentiation
The Wnt signaling pathway plays an important role in the development of many tissues in the body from the earliest stage of the process. However, the mechanisms of the Wnt pathway and the roles it plays in development remain incompletely understood. This is in part due to the complexity of …
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Development of a new screening system for the identification of RNF43-related genes and characterisation of other PA-RING family members.
… 43) is an important negative modulator of the WNT signalling pathway that acts at the plasma membrane by targeting Frizzled and its co-receptor LRP for degradation. In the small intestine, this prevents uncontrolled expansion of the stem cell compartment and so it is essential to the …
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Engineering multimodal nanoparticles to combat triple-negative breast cancer
… TNBC. One promising target for TNBC is the Wnt pathway, which is a known developmental pathway that encourages cell proliferation, migration, and cell fate determination and then transitions to mostly stem cell maintenance in adults. Unfortunately, many cancers, including TNBC, have found …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
… protein regulating a diverse array of effector pathways essential for cellular homeostasis. In most sporadic colon cancers, truncating mutations in APC lead to the loss of the Wnt pathway and microtubule regulatory domains. Studies have established key roles of mutant APC in malignant growth via …
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The Wnt Casade and Stem Cell Fate in a Basic Metazoan
The WNT signalling pathways have numerous controlling functions in embryonic development, pattern and axis formation of animals, but also play roles in sustained normal development. There are currently three known WNT signalling pathways, of which the canonical pathway is the most studied. This …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… described. This study identifies the canonical Wnt signaling pathway as a regulator of opV trigeminal placode development. Introducing dominant-negative TCF and dominant-active β-catenin expression constructs by in ovo electroporation, we have manipulated the canonical Wnt pathway within the opV …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays important roles in several other cellular processes, including cell adhesion and migration, organization of actin and microtubule networks, spindle …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays important roles in several other cellular processes, including cell adhesion and migration, organization of actin and microtubule networks, spindle …
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VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
… data specifically focusing on hyaluronan and Wnt pathway genes as they pertain to the misexpression of versican. RT-PCR and real-time PCR were used in this study to validate expression of the genes chosen. Through the use of these techniques the degree of expression has been quantified and …
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SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers
ABSTRACT Blish, Kimberly Rose SOSTDC1: A BMP/WNT DUAL ANTAGONIST IN BREAST AND RENAL CANCERS Dissertation under the direction of Suzy V. Torti, Ph.D., Associate Professor of Biochemistry The bone morphogenetic protein (BMP) pathway and the Wnt pathway are signaling networks associated with …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… myogenesis. Chapter 3 demonstrates that the Wnt signaling pathway positively regulates the expression of Foxc1/2. This result was further extended by the demonstration that beta-catenin occupies the chromatin upstream of Foxc1 during differentiation. Loss of functional Gli2 and Meox1 led to …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the formation of new bone and cartilage to initiate bone repair. We sought to determine the molecular mechanisms behind alcohol-related fracture …
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teashirt is required for head-versus-tail regeneration polarity in planarians
… specified to replace missing tissues. The Wnt signaling pathway serves a central role in specifying posterior cell fates during planarian regeneration. We identified a gene encoding a homolog of the Teashirt family of zinc finger proteins in the planarian Schmidtea mediterranea to be a …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… cells without differentiation, we focused on the Wnt pathway which is essential for self-renewal in ESCs. Differentiation of CD133+ cells to CD133- cells corresponded to down-regulation of Wnt signaling. Pharmacological activation of the Wnt pathway by (2’Z,3’E)-6-Bromoindirubin-3’-oxime (BIO) …
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Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… stromal cells (BMMSCs), bioengineered via WNT pathway activation (CHIR+ conditioned media; CM), secrete factors that promote beta-cell recovery in streptozotocin (STZ) treated NOD/SCID mice. Here, we investigated whether this regeneration process involves alpha-to-beta cell conversion, …
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