Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"within-host evolution"”.
-
Analysis of within-host evolution of Plasmodium Falciparum during treatment
… genomes and leave signatures of selection. The evolutionary basis of drug resistant malaria in endemic and epidemic settings continues to remain an ongoing scientific priority whose solution carries a significant effect on treatment outcomes. To understand the evolutionary changes in P. …
-
PATTERNS OF NATURAL SELECTION ASSOCIATED WITH TROPISM SHIFTS IN ANIMAL CORONAVIRUS GENOMES
… cross-species jumps, as well as result from within-host evolution. Beyond the human host, CoVs can be highly pathogenic to a wide variety of wildlife and companion animals. A spillover event from animals to humans, resulting in a tropism shift, has occurred at some point in the evolutionary …
-
Evolutionary Genomics of Cystic Fibrosis and Nosocomial Pathogens of the Mycobacterium abscessus species complex
… amongst people with CF and iii) to examine the within host evolution of these pathogens to uncover how these environmental organisms were adapting to the CF lung. This thesis also used whole genome sequencing to explore the largest known outbreak of MABSC infections, a post-surgical wound …
-
Host and pathogen genetics associated with pneumococcal meningitis
… treatment. The contribution of variation in host and pathogen genetics to pneumococcal meningitis is unknown. In this thesis I develop and apply statistical genetics techniques to identify genomic variation associated with the various stages of pneumococcal meningitis, including colonisation, …