Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"wingless (wg)"”.
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Lost in Translation: Variations in WNT Signaling and Other Translational Changes in a Drosophila Model of ALS
… the glypican Dally like protein (Dlp)/GPC6, a wingless (Wg/Wnt) signaling regulator is insolubilized both in flies and patient tissues with TDP-43 pathology. While Dlp/GPC6 forms puncta in the Drosophila neuropil and ALS spinal cords, it is reduced at the neuromuscular synapse in flies …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
The secreted proto-oncogene Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the …
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Regulation of Wingless secretion, distribution and signaling
<p>The evolutionarily conserved Wnt (Wingless and INT-1) family proteins are secreted cysteine-rich glycoproteins essential for embryonic patterning and adult homeostasis. Wnt signaling is highly regulated in all aspects, including the biogenesis and processing of active Wnt ligands, Wnt secretion …
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RacGap50C Is a Novel Negative Regulator of Wnt Signaling
<p>The Wingless (Wg)/Wnt signal transduction pathway directs a variety of cell fate decisions in developing animal embryos. Despite the identification of many Wg pathway components to date, it is still not clear how these proteins work together to generate cellular identities. We have carried out a …
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The role of Decapentaplegic (Dpp) in Drosophila wing development
… whether cross talk among the Hh, Dpp and Wg signaling pathways exists and what its relevance for wing patterning is. To investigate the role of Dpp in Drosophila wing development, the general strategies are to look at the phenotypes of loss-of-function and gain-of-function. Mutant clones …
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Odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos
… for the appropriate level and timing of en and wg expression in all parasegments, but opa activity alone does not determine the restricted spatial domains of these genes. I summarize some of the pair-rule circuitry through which opa acts to regulate en and wg expression in parasegment border …