Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"white matter pathology"”.
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Modelling white matter pathology and establishing a novel ex-vivo platform for drug identification in neuroinflammation
White matter (WM) makes up a critical component of the CNS, composed primarily of myelinated axons. Herein, axons and the myelin sheath form a dynamic and communicative axo-glial unit which acts to regulate and support axonal function. The myelin sheath not only electrically insulates axons …
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Component diffusion tensor analysis suggests disparate temporal stem and fornix white matter pathology in Mild Cognitive Impairment
… We present data suggesting that integrity of the white matter (WM) of the limbic system, specifically the fornix, is reduced in the early stages of neurodegeneration observed in MCI. We also present data which indicate fornix integrity is linked to specific decrements in a neuropsychological …
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Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
Recent clinical studies suggest that white matter pathology rather than grey matter abnormality is the major neurobiological substrate of age- related cognitive decline during “healthy” aging. According to this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. …
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Investigating the role of TREM2 and neuroinflammation in an experimental model of chronic cerebral hypoperfusion
… disease is associated with the development of white matter damage, cognitive impairment and dementia. Although incompletely understood, recent studies suggest neuroinflammation is a key mechanism driving vascular pathology, white matter damage and cognitive decline. Neuroinflammation is …
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Apathy after stroke: clinical characteristics, association with functional outcome and effect on carer burden
… bases of apathy found an association with white matter pathology, reinforcing the idea that chronic ischaemia coupled with acute lesions might set up a cascade of events leading to apathy. A new study was then set up to investigate the effects of apathy on carers of patients with small …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… with an increased risk of developing VCI. White matter alterations are a prominent pathological feature observed in patients with VCI thought to underlie cognitive impairment. Neuroimaging studies show a positive correlation between the burden of white matter alterations and progressive …
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Investigating disturbances of brain 5-HT systems by experimental MRI and SPECT neuroimaging
… in the detection of conceivably mild changes in white matter involving the serotonin system, a mouse model of life-long SERT deficiency was studied. Secondly, in order to validate DTI image processing methodology, a mouse model with reportedly profound myelin dysfunction was examined. Histology …