Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"white matter integrity"”.
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Aging and Cognitive Control: Hemispheric Differences and White Matter Integrity
… in cognitive control have been associated with white matter as well as gray matter decline. Specifically, it has been established that anterior regions of the corpus callosum (aCC) decline with advanced age. This decline in aCC may lead to a reduction in the ability of the pre-frontal cortices …
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White Matter Integrity And Age Related Differences In Reaction Time Components
… advanced aging. Age-related deterioration in white matter integrity might play a role in age-related increase in reaction time (RT). However, the association between microstructural differences in particular white matter regions or tracts with RT is unclear. Decomposing RT into parts might be …
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Normalization of Cerebral Blood Flow, Neurochemicals, and White Matter Integrity After Kidney Transplantation
… (CBF), cerebral neurochemical concentrations and white matter integrity, each of which are associated with adverse clinical consequences in the non-CKD population, and may explain the high prevalence of dementia and stroke in end stage kidney disease (ESKD). Since cognition improves after kidney …
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Impact of the mind diet on cognition and white matter integrity in an older adult cohort
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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The influence of maternal HIV and ART exposure on neonate brain white matter integrity and organisation
… as ART exposure in utero and at birth affect white matter (WM) structure and its connectivity. This study used diffusion tensor imaging (DTI) tractography and graph theory to examine the possible influence of HIV and ART exposure in utero on neonate WM integrity (as measured by DTI parameters) …
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Physical Activity and its Association with White Matter Integrity and Cognitive Efficiency in Pediatric-Onset Multiple Sclerosis
In healthy children and adolescents, increased white matter integrity is highly correlated with cognitive and language development. Moreover, higher level of physical activity has been shown to confer positive effects on cognition and is associated with increased white matter microstructure in …
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Fine Motor Skills, Processing Speed, And White Matter Integrity Among Pediatric Brain Tumor Survivors Who Received Proton Radiotherapy
… often manifests as damage to microstructure of white matter tracts, which is measured through diffusion tensor imaging (DTI). Additionally, the neurotoxicity of XRT contributes to maladaptive neurocognitive function and quality of life. In recent decades, proton radiotherapy (PRT) has been …
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The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention
Cerebral white matter degeneration occurs with increasing age and is associated with declining cognitive function. Given the expected rise in the number and proportion of older adults in the United States, it is imperative to identify lifestyle factors that can counteract the deleterious effects of …
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Aging and cortical recruitment in response to cognitive challenge
… by task demands, constrained by individual’s white matter integrity and external experience. In Experiment 1, I use the functional magnetic resonance imaging (fMRI) to reveal reduced BOLD-measured activity in older compared to young adults under demanding conditions in executive processing …
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Cognitive Correlates Of Fatigue In Pediatric-Onset Multiple Sclerosis
… POMS participants demonstrated lower whole brain white matter integrity relative to HCs and while generally in the expected direction, white matter integrity was not significantly associated with fatigability on the CPT. Until there is a cure for MS, it is essential that we continue to understand …
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Multimodal Investigation of Neurobiological Alterations in the At Risk Mental State and First Episode of Psychosis
… respectively. Subsequently, I characterised white matter integrity of fronto-temporal connections by performing a virtual in vivo interactive dissection of the main white matter tracts thought to connect temporal, cingulate and frontal regions. Finally, I explored the relationship between …
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The relationship between neurocognitive disorders, prospective memory impairment and white matter damage in clade C HIV-positive subjects
… function and Diffusion tensor imaging (DTI)/ White matter integrity of human immunodeficiency virus (HIV) positive individuals in the Western Cape. We hypothesize that: 1. Individuals infected with HIV will exhibit significantly poorer microstructural integrity of the white matter than HIV …
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Age-related differences in visuomotor integration as measured by object affordance effects - a combined behavioural and neurophysiological investigation
… importance as age-related degeneration of white matter integrity is well documented. Consequently, if successful visuomotor behaviour relies on white matter integrity, age-related reductions in affordance effects should be observed. This prediction was tested in a series of experiments. …
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Cognitive-Motor Integration In Normal Aging And Preclinical Alzheimer's Disease: Neural Correlates And Early Detection
… revealed significant age-related declines in white matter integrity that were more pronounced in the high AD risk group. Decreased functional connectivity in the default mode network (DMN) was also found in high AD risk participants. Furthermore, measures of white matter integrity and …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
… Emerging clinical imaging evidence suggests that white matter degeneration, secondary neurodegeneration and inflammation in areas like the corpus callosum and thalamus after a middle cerebral artery stroke may contribute to cognitive decline. The aim of the current study was to examine remote grey …
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Concussion Recovery and Skilled Performance in Working-Aged Adults: Sex Differences in the Neural Correlates of Persisting Symptoms After Concussion
… movement. We previously identified links between white matter integrity and visuomotor performance in working-age adults with persistent post-concussion symptoms (PPCS). We investigated the impact of sex, age, and CMI processes on visuomotor performance in PPCS. Forty-two adults (47.5 ± 9.87 …
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Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
Recent clinical studies suggest that white matter pathology rather than grey matter abnormality is the major neurobiological substrate of age- related cognitive decline during “healthy” aging. According to this hypothesis, cerebrovascular (e.g. chronic cerebral hypoperfusion) and molecular (e.g. …
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Characterization of metal artifacts in diffusion tensor imaging for spinal cord applications
… This can give useful information regarding white matter integrity and has the potential to provide important biomarkers in spinal cord injury. One of the largest challenges in DTI of the spinal cord is the presence of metal which causes geometric distortions, signal pile-up, and signal …
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Investigating Diffusion Tensor Imaging Correlates of Cognitive Impairment In Idiopathic Normal Pressure Hydrocephalus and Alzheimer'S Disease
… do this, we compared cognitive performance and white matter integrity between patients with “pure” iNPH, “pure” Alzheimer’s disease (AD), and co-morbid iNPH + AD. Our results demonstrated that there are specific periventricular structures in the brain that are associated with cognitive …
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Brains, genes and environment of suicide attempters
… listening has been associated with reduced white matter integrity, prefrontal functioning and response to treatment in depression. Perceptual asymmetry correlated with clinical measures of suicidality in 20 suicide attempters.
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