Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"white matter development"”.
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… characteristic bilateral, symmetric deep gray matter lesions observed on MRI. While this neuron-centric perspective helps explain regional vulnerability in LS, it overlooks the substantial mitochondrial demand of neural stem/progenitor cells (NSCs), which generate the majority of the brain …
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Microglia and Myelin: Improved Tools and Molecular Interactions
… to promote signal transduction and the development of a compact and energy-efficient nervous system. Myelin development and homeostasis are critical for normal function and impairment of myelin is associated with sensory, motor, and cognitive dysfunction. While it has long been …
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Understanding Brain Signal Variability and Why it Matters in Maturation from Childhood to Adulthood
… the association between BOLD SD, age, and white matter development during early childhood. Across- and within-participant analyses demonstrated that white matter maturation was closely linked to alterations in brain function as measured by BOLD SD. Study 2 examined the relationship between …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
… hospital stays, repeated infections, and neurodevelopmental delays. These children also have an increased risk for chronic inflammation and psychiatric diseases later in life. Inflammation during early development is associated with psychiatric disease risk by disrupting normal …
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Quantitative Analysis of Normal-Appearing White Matter In Pediatric Phenylketonuria
… (PKU) is a metabolic disorder that results in white matter abnormalities with varying degrees of severity. The analysis of brain structure in children with PKU using magnetic resonance imaging (MRI) has been limited by the reliance on qualitative data to characterize white matter abnormalities. …
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Nutrient-based strategies to enhance docosahexaenoic acid (DHA) utilization in the piglet brain
… formula and maternal milk on post-natal neurodevelopmental patterns. Over a 25-day feeding study, piglets (n=9-10 per treatment, 1.5 ± 0.2 kg initial BW) were either sow-reared (SR) with ad libitum intake, or artificially-reared (AR) receiving 1 of 3 milk replacers modified to mimic the …
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Effects of iron deficiency upon neurodevelopment, metabolism, and inflammation
… few years of life are a critical period in neurodevelopment. During this time, multiple developmental processes occur in tandem, rendering the brain especially vulnerable to environmental insults. The coordination of complex neuronal processes, including myelination and synaptogenesis, may be …
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
… from oligodendrocyte precursor cells. During development neurons become myelinated, and this process can be modulated by environmental factors, ageing and various neurological disorders. The notion that myelin plays a role in learning has increasingly received attention within the scientific …