Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 332 for “"white matter"”.
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Ionic dysregulation in white matter damage
White matter damage can occur in a variety of neurological diseases where it contributes significantly to impairment of brain function. Dysregulation of ion gradients across membranes is a common phenomenon across many diseases and can be damaging due to increased metabolic demand, oedema and …
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Excitotoxic Injury Mechanisms in Central White Matter
… (CNS). Myelin injury is a common feature of white matter (WM) pathology in a number of disease states, including ischemic stroke. Myelin disruption can lead to a complete failure in saltatory action potential conduction, resulting in devastating neurological deficits. However, the fundamental …
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Cerebral white matter analysis using diffusion imaging
… can be used to create a representation of white matter tracts in the brain via a process called tractography. Whole brain tractography outputs thousands of trajectories that each approximate a white matter fiber pathway. Our method performs automatic organization, or segmention, of these …
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Intraindividual Variability as a Correlate of White Matter Decline
… increase in IIV has been associated with white matter volumes and microstructure. However, the association between IIV and white matter has not been contextualized with other aspects of cognitive performance and neuroanatomical structure, in particular with median reaction time and …
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Quantitative Analysis of Normal-Appearing White Matter In Pediatric Phenylketonuria
… (PKU) is a metabolic disorder that results in white matter abnormalities with varying degrees of severity. The analysis of brain structure in children with PKU using magnetic resonance imaging (MRI) has been limited by the reliance on qualitative data to characterize white matter abnormalities. …
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Acute, Low-Grade Inflammation elevates White Matter Sensitivity to Ischaemia
… infection, has emerged as a risk factor. White matter axons, and their supporting glia, are susceptible to both ischaemic and neuroinflammatory injury. The mechanisms behind ischaemic injury in white matter are well established. However, the white matter response to acute, low-grade …
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COMPUTATIONAL SEGMENTATION OF WHITE MATTER ANATOMY: METHODS, INSIGHTS, AND STANDARDS
… larger and more gyrified the routes between grey matter structures became correspondingly longer and more complicated. This has required axons to form a complex network of bundles in order to maintain connectivity between distal regions, giving rise to the tissue known as “white matter”. Although …
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Aging and Cognitive Control: Hemispheric Differences and White Matter Integrity
… in cognitive control have been associated with white matter as well as gray matter decline. Specifically, it has been established that anterior regions of the corpus callosum (aCC) decline with advanced age. This decline in aCC may lead to a reduction in the ability of the pre-frontal cortices …
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Relationship between white matter changes and aggression in methamphetamine dependence
… on the brain leading, amongst other effects, to white matter (WM) changes. Moreover, increased levels of aggression are commonly found in individuals with MA abuse. Although behavioural deficits are well described, the underlying mechanisms are still poorly understood. While previous studies have …
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Quantitative analysis of cerebral white matter anatomy from diffusion MRI
… develop algorithms for quantitative analysis of white matter fiber tracts from diffusion MRI. The presented methods enable us to look at the variation of a diffusion measure along a fiber tract in a single subject or a population, which allows important clinical studies toward understanding the …
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Cerebellar White Matter Microstructure and Cognition in Pediatric-Onset Multiple Sclerosis
… respect to the association between cerebellar white matter microstructure and cognitive efficiency. Patients demonstrated reduced efficiency on a computerized cognitive battery, relative to healthy controls, most notably on tasks that were timed, or where participants were instructed to respond …
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White Matter Integrity And Age Related Differences In Reaction Time Components
… advanced aging. Age-related deterioration in white matter integrity might play a role in age-related increase in reaction time (RT). However, the association between microstructural differences in particular white matter regions or tracts with RT is unclear. Decomposing RT into parts might be …
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Cardiovascular Risk Factors Predict the Spatial Distribution of White Matter Hyperintensity
… identify the different spatial distribution of white matter hyperintensity (WMH) associated with specific risk factors and use this distribution to estimate the extent of risk factor associated WMH in an individual. MATERIALS AND METHODS: MRI brain images were obtained from 2066 healthy adult …
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White matter connectivity, cognition, symptoms and genetic risk factors in Schizophrenia
… around 1%. It is often characterised by impaired white matter structural dysconnectivity. In vivo and post-mortem alterations in white matter microstructure have been reported, along with differences in the topology of the structural connectome; overall these suggest a reduced communication …
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Intraindividual variability and micro-structural white matter changes in Alzheimer’s disease
… IIV researchers have highlighted the role of white matter in increased IIV, and micro-structural white matter changes have been implicated in the early stages of AD. The current study examined the relationship between IIV on simple and choice reaction time tasks and micro-structural white …
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White matter correlates of neuropsychological function in young adult methamphetamine users
… to explore whether these deficits correlate with white matter (WM) microstructural abnormalities using diffusion tensor imaging (DTI). Methods: Twenty-one MA dependent individuals recently enrolled in an outpatient rehabilitation program and nineteen healthy controls participated in the study. …
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… a major factor contributing to periventricular white matter (PWM) damage in neonates. Microglial cells and astrocytes play a crucial role in inflammatory response. This study investigated their role in PWM damage (PWMD) in hypoxic conditions. The potential mechanisms by which amoeboid microglial …
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The effect of repetitive head impact exposure on white matter lesion volume
… on whether RHI from CCS result in changes to white matter and long-term neurobehavioral outcomes, therefore this research project seeks to provide supporting evidence by comparing the total volume of fluid-attenuated inversion recovery (FLAIR) white matter lesions in individuals with a history …
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Establishment of the white matter stroke model in rats to study oligodendrogenesis
… In this stroke, ischemic injuries to the white matter result in demyelination leading to defective neural connection between the cerebral cortex and subcortical structures. Therefore, repair of the ischemic demyelination by enhancing endogenous oligodendrogenesis would be a plausible …
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DTI-based tractographic analysis of white matter alterations in HIV infected children
… Previously, we found HIV-associated changes in white matter and functional networks in a cohort of 7-year-old HIV infected (HIV+) children who intiatied early cART compared to uninfected controls. To explore possible relationships between these alterations, we used tractography to identify …
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