Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"white adipose tissue (WAT)"”.
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat cells become hypertrophic it promotes a metabolically unhealthy phenotype, which is characterized by chronic low-grade inflammation, insulin resistance, and ectopic lipid …
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
White adipose tissue (WAT) is a complex tissue composed mostly of adipocytes, but contains other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… alter the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, …
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Role of Tyk2 in the Development of Beige Cells
Obesity results from an excess of adipose tissue and is a major risk factor for type 2 diabetes, cardiovascular disease, and cancer. Adipose tissue exists in two main forms: white adipose tissue (WAT), which stores energy as triglycerides, and brown adipose tissue (BAT), which dissipates stored …
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Distinct Functional Properties of Perinatal Versus Adult Adipose Progenitor Subpopulations
The manner in which energy-storing white adipose tissue (WAT) expands and remodels in obesity is tightly linked to the development of metabolic syndrome. The recruitment of new fat cells ensures adequate energy storage in WAT and prevents against ectopic lipid accumulation and is therefore …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… protein 1 (UCP1) or the browning of the white adipose tissue (WAT) vs. controls. Next generation RNA sequencing of AhR-CKO vs. control mice liver transcriptomes revealed significantly increased expression of fibroblast growth factor (FGF) 21, a known hepatokine and activator of …
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Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… the underlying pathophysiology remained unclear. Adipose stromal cells (ASC) are adipose tissue-derived mesenchymal progenitors, abundant in white adipose tissue (WAT). In this study, we show that the ASC pool is expanded in obesity and is associated with promoted tumor growth. Next, by using a …
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Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation
… PPARgamma in vitro and significantly ameliorates white adipose tissue (WAT) inflammation and glucose tolerance in db/db mice. We next further examined the effect of ABA on the phenotype of adipose tissue macrophages (ATMs). In doing so, we discovered two separate ATM populations which differed in …
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The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
… NLRP3 inflammasome activation and expression in white adipose tissue (WAT) of burn patients and that its pro-inflammatory by-products increase with increasing injury severity. In Chapter 3, we studied the effect that NLRP3 knockout would have on survival and the immune response in rodents. …
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The Role of Adipocytes in the Tumor Microenvironment in Obesity-Driven Breast Cancer Progression
… cancer develops in an environment containing white adipose tissue (WAT) which predominately consists of mature white adipocytes. In obesity, WAT undergoes hypertrophy and hyperplasia and can ultimately develop hypoxia, insulin resistance, inflammation, and dysregulated endocrine function. …
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Lipid metabolism and mitochondrial respiration in adipose tissue and liver during obesity
… as obese in 2024. Most fats are stored in white adipose tissue (WAT), which is greatly expanded during obesity, and shows impaired energetic function. In addition, the liver is a key site of ectopic fat deposition in obesity, resulting in changes in metabolic function. It has been proposed …
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White Adipose Tissue Remodeling by Intermittent Fasting
… regulator of energy balance, understanding white adipose tissue (WAT) homeostasis and its response to dietary challenges is crucial to reveal the mechanisms of IF-mediated metabolic benefits. Particularly, recent studies highlighted the role of dysfunctional adipocyte progenitors (APs) in …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
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Hormone-Sensitive Lipase - New roles in adipose tissue biology
… of the HSL gene in mice, with a focus on the white adipose tissue (WAT). The initial study demonstrated a mild insulin resistance in multiple tissues of the HSL null mice, which was almost fully compensated for by increased insulin secretion by the pancreatic beta-cells. The HSL null mice were …
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Fatty Acid Fate In Determining Oxidation And Inflammation In Adipose Tissue
<p>Adipose tissue (AT) is a critical regulator of energy balance through its ability to store or oxidize free fatty acids (FFAs). White adipose tissue (WAT) functions as an anabolic organ to sequester and release FAs, in contrast brown adipose tissue (BAT) is a catabolic organ that oxidizes FAs. …
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Effects of exercise and phytoestrogens on white adipose tissue health in estrogen deficient rodents
… dysfunction, insulin resistance (IR), and white adipose tissue (WAT) inflammation increasing susceptibility for cardiovascular disease, type 2 diabetes, and many types of cancer. Ovariectomy (OVX) in rodents, a model of human menopause, is associated with reduced energy expenditure (EE), …
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The Impact of Adipose-Associated Stromal Cells on the Metastatic Potential of Ovarian Cancer
… to cancer progression, specifically focusing on adipose tissue-derived stem and progenitor cells, which have previously been shown to be recruited by cancer cells and participate in cancer progression. We confirmed that ovarian cancer tumor burden was indeed significantly increased in mice on a …
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Function and activation of human adipose tissue: The role of genes in the link between physical activity and brown adipose-like phenotype
Background: Excess white adipose tissue (WAT) in humans is considered as a harmful health index. However, increased brown adipose tissue (BAT) and brown-like adipose tissue activity are associated with increased resting energy expenditure (REE) that may help to control body weight. Exercise may …
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Role of GPS2 in the regulation and maintenance of adipose tissue physiology and function under metabolic stress and obesity
… health issues that result from dysfunctions of white adipose tissue (WAT). As an endocrine organ, WAT is often possessed of a high degree of plasticity, capable of matching the metabolic conditions of which it is presented and responsible for maintaining an overall homeostatic energy balance. …
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Carnosic acid against insulin resistance and obesity. Investigating its effects on adipocytes.
Adipose tissue plays a crucial role in regulating metabolic homeostasis, and its dysfunction in obesity leads to insulin resistance and type 2 diabetes (T2D). White adipose tissue (WAT) primarily stores energy as lipids while brown adipose tissue (BAT) regulates thermogenesis by dissipating energy …
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