Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"white adipose tissue"”.
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… alter the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, …
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White Adipose Tissue Remodeling by Intermittent Fasting
… regulator of energy balance, understanding white adipose tissue (WAT) homeostasis and its response to dietary challenges is crucial to reveal the mechanisms of IF-mediated metabolic benefits. Particularly, recent studies highlighted the role of dysfunctional adipocyte progenitors (APs) in …
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Effects of exercise and phytoestrogens on white adipose tissue health in estrogen deficient rodents
… dysfunction, insulin resistance (IR), and white adipose tissue (WAT) inflammation increasing susceptibility for cardiovascular disease, type 2 diabetes, and many types of cancer. Ovariectomy (OVX) in rodents, a model of human menopause, is associated with reduced energy expenditure (EE), …
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Impact of the chromatin remodeller SMARCAD1 on murine intestinal intraepithelial lymphocyte and white adipose tissue biology.
… murine intestinal intraepithelial lymphocyte and white adipose tissue biology. Chromatin remodelling factors use the energy of ATP hydrolysis to drive the movement of and/or affect molecular changes to the nucleosome. One such factor, SMARCAD1 (SWI/SNF-related matrix-associated actin-dependent …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
White adipose tissue (WAT) is a complex tissue composed mostly of adipocytes, but contains other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone …
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Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… efficiency and metabolic flexibility in tissues associated with energy sensing and storage, and relative cellular hypertrophy in white adipose tissue. Hypothalamus, liver, Pectoralis major, gastrocnemius, abdominal fat, clavicular fat and subcutaneous fat were collected from juvenile …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… lipidomic and transcriptomic study of white adipose tissue in mice that become obese either through genetic modification (ob/ob genotype), diet (high-fat diet) or a combination of the two across the life course. Specifically, I demonstrated that the changes in triglyceride metabolism …
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Role of Tyk2 in the Development of Beige Cells
Obesity results from an excess of adipose tissue and is a major risk factor for type 2 diabetes, cardiovascular disease, and cancer. Adipose tissue exists in two main forms: white adipose tissue (WAT), which stores energy as triglycerides, and brown adipose tissue (BAT), which dissipates stored …
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Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… the underlying pathophysiology remained unclear. Adipose stromal cells (ASC) are adipose tissue-derived mesenchymal progenitors, abundant in white adipose tissue (WAT). In this study, we show that the ASC pool is expanded in obesity and is associated with promoted tumor growth. Next, by using a …
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Nutrient sensing by the mTORC1 pathway in physiology
… Sestrin1 and Sestrin2 fail to inhibit mTORC1 in tissues when deprived of dietary leucine. These mice suffer from severe loss of white adipose tissue and skeletal muscle when deprived of leucine, but not other essential amino acids. We showed that their white adipose tissue loss results from …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
Obesity and aging remodel adipose tissue in ways that reduce the abundance and function of thermogenic beige and brown adipocytes, lowering energy expenditure and worsening metabolic disease. Beige adipocytes arise within white adipose tissue in response to environmental and hormonal cues, whereas …
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Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells
… the enzyme hydrolyzing acylglycerides stored in adipose tissue. But HSL has broad substrate specificity and is widely expressed elsewhere than in adipose tissue. Its role in non-adipose tissues is not completely understood, but the phenotype revealed by the characterization of several …
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THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat cells become hypertrophic it promotes a metabolically unhealthy phenotype, which is characterized by chronic low-grade inflammation, insulin resistance, and ectopic lipid …
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Transcriptional Regulation Of Adipocyte Function
<p>The increased white adipose tissue mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte …
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The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… lipid handling in the liver, skeletal muscle and adipose tissue 3) determine the effect of Jz-Igf2UE on adipose tissue respirometry, and on the gonadal adipose transcriptome. The impact of Jz-Igf2UE on offspring metabolic health was evaluated via insulin tolerance tests, metabolic cage assessments …
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Adipocytes and Innate Immunity In Systemic Sclerosis
… is a chronic systemic autoimmune and connective tissue disorder characterized by vasculopathy, autoimmune phenomena, and widespread fibrosis. Skin thickening and tightening is the cardinal feature of SSc and is responsible, in part, for the considerable morbidity of this disease. There are …
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Impact of obesity on stromal vascular fraction in adipose tissue as it relates to ovarian cancer
… in addition to the adipocytes, abdominal white adipose tissue contains the stromal vascular fraction (SVF) which includes stem and progenitor cell populations, immune cells, and fibroblasts. Since the SVF can also be recruited by the cancer cells, we investigated how obesity affects the …
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Building an In-vitro Cell Model to Study Cellular Basis of Maturation Timing: A Proof of 3D Cell Culture Methodology in Atlantic Salmon Adipose Tissue
… cellular cultures have been shown to represent tissue formations and functions more accurately than two-dimensional (2D) cultures and have been successfully utilized more accurately in model organisms, e.g., to understand cellular modular functions. However, the applications in non-model …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… metabolism in the liver, skeletal muscle and white adipose tissue using Western blotting. RNA sequencing and bioinformatic analysis was used to assess changes in gene expression/functional pathways in fetal livers and select differentially expressed genes were quantified in adult offspring …
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