Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 80 for “"white adipose"”.
-
Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… alter the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, …
-
White Adipose Tissue Remodeling by Intermittent Fasting
… regulator of energy balance, understanding white adipose tissue (WAT) homeostasis and its response to dietary challenges is crucial to reveal the mechanisms of IF-mediated metabolic benefits. Particularly, recent studies highlighted the role of dysfunctional adipocyte progenitors (APs) in …
-
Effects of exercise and phytoestrogens on white adipose tissue health in estrogen deficient rodents
… dysfunction, insulin resistance (IR), and white adipose tissue (WAT) inflammation increasing susceptibility for cardiovascular disease, type 2 diabetes, and many types of cancer. Ovariectomy (OVX) in rodents, a model of human menopause, is associated with reduced energy expenditure (EE), …
-
Impact of the chromatin remodeller SMARCAD1 on murine intestinal intraepithelial lymphocyte and white adipose tissue biology.
… murine intestinal intraepithelial lymphocyte and white adipose tissue biology. Chromatin remodelling factors use the energy of ATP hydrolysis to drive the movement of and/or affect molecular changes to the nucleosome. One such factor, SMARCAD1 (SWI/SNF-related matrix-associated actin-dependent …
-
The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) that carry out essentially opposite functions. WAT is primarily involved in storing excess energy, whereas BAT burns excess energy …
-
Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
White adipose tissue (WAT) is a complex tissue composed mostly of adipocytes, but contains other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone …
-
Chickens Selected for High Body Weight Show Relative Impairment in Fatty Acid Oxidation Efficiency and Metabolic Flexibility in Skeletal Muscle and White Adipose Tissue
… storage, and relative cellular hypertrophy in white adipose tissue. Hypothalamus, liver, Pectoralis major, gastrocnemius, abdominal fat, clavicular fat and subcutaneous fat were collected from juvenile (56-65 day-old) HWS and LWS chickens for metabolic, gene expression and histological assays. …
-
The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3-adrenergic agonist.
… is the $\beta$3-adrenergic receptor in brown and white adipose tissues. Selective $\beta$3-adrenergic receptor agonists have been developed that will stimulate both the mobilization of fat from white adipose tissue, the site of triacylglycerol storage in the body, and the oxidation of this fat in …
-
The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… lipidomic and transcriptomic study of white adipose tissue in mice that become obese either through genetic modification (ob/ob genotype), diet (high-fat diet) or a combination of the two across the life course. Specifically, I demonstrated that the changes in triglyceride metabolism …
-
Role of Tyk2 in the Development of Beige Cells
Obesity results from an excess of adipose tissue and is a major risk factor for type 2 diabetes, cardiovascular disease, and cancer. Adipose tissue exists in two main forms: white adipose tissue (WAT), which stores energy as triglycerides, and brown adipose tissue (BAT), which dissipates stored …
-
The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
Brown adipose tissue (BAT) is a recently re-discovered tissue in humans. The role of BAT in thermogenesis and metabolic regulation has been established in rodents. However, the physiological and clinical significance of this tissue in humans has not been proven yet. The purpose of these …
-
Mobilization of Adipose Stromal Cells In Obesity and Cancer By Sparc and Its Proteolytic Isoforms
… the underlying pathophysiology remained unclear. Adipose stromal cells (ASC) are adipose tissue-derived mesenchymal progenitors, abundant in white adipose tissue (WAT). In this study, we show that the ASC pool is expanded in obesity and is associated with promoted tumor growth. Next, by using a …
-
Distribution of S-(2-Succinyl)Cysteine In the Tissues of Animal Models of Diabetes and Obesity
… we have seen increased succination in adipose tissue of the db/db type 2 diabetic mouse model. Consequently, this study focuses on the distribution of 2SC within various organs, skeletal muscles, and adipose tissues of the db/db mouse. In addition, another type 2 diabetic model, the …
-
Nutrient sensing by the mTORC1 pathway in physiology
… leucine. These mice suffer from severe loss of white adipose tissue and skeletal muscle when deprived of leucine, but not other essential amino acids. We showed that their white adipose tissue loss results from mTORC1 dysregulation in the liver and is driven by aberrant production of the …
-
Lipid metabolism and mitochondrial respiration in adipose tissue and liver during obesity
… as obese in 2024. Most fats are stored in white adipose tissue (WAT), which is greatly expanded during obesity, and shows impaired energetic function. In addition, the liver is a key site of ectopic fat deposition in obesity, resulting in changes in metabolic function. It has been proposed …
-
Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
Obesity and aging remodel adipose tissue in ways that reduce the abundance and function of thermogenic beige and brown adipocytes, lowering energy expenditure and worsening metabolic disease. Beige adipocytes arise within white adipose tissue in response to environmental and hormonal cues, whereas …
-
Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells
… the enzyme hydrolyzing acylglycerides stored in adipose tissue. But HSL has broad substrate specificity and is widely expressed elsewhere than in adipose tissue. Its role in non-adipose tissues is not completely understood, but the phenotype revealed by the characterization of several …
-
Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… problems worldwide including United States. Adipose tissue is the primary site of energy storage, playing important roles in health. Adipose tissue also has other critical functions, producing adipocytokines and contributing to normal nutrient metabolism, which in turn play important roles in …
-
THE EFFECTS OF ESTROGENIC COMPOUNDS ON ADIPOGENESIS VIA PPARγ AND CANONICAL WNT SIGNALING
… arise in response to cellular changes in white adipose tissue (WAT). In particular, when a majority of fat cells become hypertrophic it promotes a metabolically unhealthy phenotype, which is characterized by chronic low-grade inflammation, insulin resistance, and ectopic lipid …
-
Transcriptional Regulation Of Adipocyte Function
<p>The increased white adipose tissue mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte …
Page 1 of 4