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Showing 1 to 14 of 14 for “"wet granulation"”.
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A detailed, stochastic population balance model for twin-screw wet granulation
… population balance model for twin-screw granulation using the stochastic weighted particle method. A number of new particle mechanisms are introduced and existing mechanisms augmented including immersion nucleation, coagulation, breakage, consolidation, liquid penetration, primary …
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Optimisation of granola breakfast cereal manufacturing process by wet granulation and pneumatic conveying
… breakfast cereal manufacturing processes by wet granulation and pneumatic conveying. Granola is an aggregated food product used as a breakfast cereal and in cereal bars. Processing of granola involves mixing the dry ingredients (typically oats, nuts, etc.) followed by the addition of a binder …
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Effect of a wet granulation manufacturing process on the stability of a pharmaceutical drug product
This thesis deals with the application of thermal analysis techniques to understand the root cause of low assay results observed during stability testing of a commercial drug product containing ethinyl estradiol and goes on to suggest improvements that could be made to the commercial manufacturing …
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MULTI-SCALE MODELING OF HIGH-SHEAR GRANULATION
High shear wet granulation is a particle design process used to increase the size of a primary powder material through the addition of liquid binder. This thesis focuses on the multi-scale nature of high-shear granulation in order to understand behavior changes due to coupled consolidation and …
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Optimization of granule size and tablet properties in a twin screw granulator: the influence of process and formulation parameters
… step and other associated processing costs in wet granulation is a benefit of melt granulation. However, twin screw hot melt granulation is rarely applied in most industries. This work details the product characteristics and optimization from melt granulation of the model materials, calcium …
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COMPRESSION AND MOISTURE EFFECTS ON THE STABILITY OF DRY VITAMIN A ACETATE IN COMPRESSED TABLETS
… were in the method of producing the final granulation, that is using both wet granulation and slugging procedures, as well as varying the moisture contents in the different formulations. A hardness-compression force relation was established for each individual granulation in. order to …
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Process analytical technology in tablet manufacturing
… manufacturing process; blending by cube mixer, granulation by twin-screw extruder and including finished product properties. Critical process parameters were identified through design of experiments (DoE), and then data of each step was recorded by widely accepted PAT approaches (e.g. …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… acetate can be prepared by direct compression or wet granulation methods. However, previous studies showed that a large amount of CA was required to achieve the desired sustained release profile for a sparingly soluble drug and it was difficult to formulate a highly water soluble drug by using CA …
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Characterisation of Tablets and Roller-Compacted Ribbons with Terahertz Time-Domain Pulsed Imaging
The pharmaceutical process of dry granulation using roller-compaction (DG/RC) is effectively a non-batch based procedure orientated to deliver a continuous stream of material free of a pre-defined batch-size with reduced plant equipment/scale-up R&D resources and an enhanced work-throughput, …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… (4.5 mm in diameter) were produced by the wet granulation method. The release profiles from several encapsulated minimatrices in phosphate buffer solution (pH 7.0) showed that xanthan, karaya and locust bean gums could sustain the release of diclofenac sodium while the carrageenan gum did …
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Mechanical dispersion of semi-solid binders in high-shear granulation
<p>Granulation is an important industrial process used to produce many foods, medicines, consumer products, and industrial intermediate products. This thesis focuses on high shear wet granulation with the specific case study of detergent manufacture using a high shear pin mixer. The key rate …
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Drug release from pellets and matrices based on cellulose ethers.
… were prepared either by direct compression or wet granulation. Compendial dissolution methodology was used to determine drug release from coated pellets as well as matrices. Release exponents indicating release mechanisms were calculated from the dissolution data. The release of both drugs from …
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Modification of natural hydrophilic polymers for use in pharmaceutical formulations
… using direct compression as well as spray, wet and dry granulation. The effect of the ratio of the two components, percentage of lubricant and particle size on the properties of the prepared co-processed excipient has been investigated. -Chitin forms non-hygroscopic, highly compactable, …
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NANOSUSPENSIONS-BASED ORAL DELIVERY PLATFORMS - NANODPS
In questa tesi di dottorato è stato studiato il potenziale delle nanosospensioni (NS) come intermedi di produzione per il miglioramento della solubilità e, di conseguenza, della biodisponibilità orale di farmaci scarsamente solubili in acqua, attraverso lo sviluppo di approcci tecnologici per la …