Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"wasting disease"”.
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Antibiotics and the Wasting Disease in Neonatally Thymectomized Rats
… diminishes the incidence of the so-called "Wasting Disease" in neonatally thymectomized rats.</p> <p>A total of 50 rats were divided into the following groups:</p> <ol> <li>Thymectomy only---nonmedicated 17 rats</li> <li>Thymectomy only---medicated 12 rats</li> …
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Landscape Ecology of Chronic Wasting Disease in Virginia, USA
Wildlife diseases often occur under quantifiable and consistent patterns, which can be understood to statistically predict their occurrence and spread across landscapes. Chronic wasting disease (CWD) is a neurodegenerative disease in the deer family Cervidae caused by a prion, a pathogenic and …
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Molecular ecology and hierarchical models elucidate chronic wasting disease dynamics
… scenario because a single gene codes for both a disease agent and a functionally constrained native protein. The prion precursor gene, Prnp, codes for the prion precursor protein, PrP, which is constitutively expressed as a native isoform within all mammals. Upon misfolding to the disease …
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Investigating genetic vulnerability to chronic wasting disease in endangered cervid taxa
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE). TSEs are a group of progressive neurodegenerative diseases caused by prions. Prions are misfolded infectious proteins with a stable altered structure that allows them to induce conformational changes in normal …
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Hunters' responses to chronic wasting disease: specialization, social trust, and perceived risk
Chronic wasting disease (CWD) is found in deer, elk, and moose in several states and provinces. CWD causes abnormal behavior, emaciation, and death in all infected animals. Although CWD has not caused human health problems, transmission to humans cannot be dismissed. Little is known about the …
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Plant-Pathogen Interactions Associated with Wasting Disease in the Tropical Seagrass Thalassia testudinum.
Lipopolysaccharide (LPS) was shown to serve as a strong elicitor of the early defense response in the subtropical seagrass Thalassia testudinum Banks ex König and was capable of inducing an oxidative burst identified at the single cell level. The formation of reactive oxygen species (ROS) included …
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Sea Star Wasting Disease in Pisaster Ochraceus on the Washington Coast and in Puget Sound
… of its intertidal community. Sea star wasting disease is an illness that causes sea star tissues to become necrotic until the creature wastes away and dies. In 2013, a coast wide outbreak of sea star wasting disease caused a mass mortality event in <em>P. ochraceus. </em>The goals of …
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Timing recombinant prion protein conversion as a measure of prion activity in chronic wasting disease
Chronic Wasting Disease (CWD) is a fatal neurological disease affecting cervids caused by prions. Infected cervids shed the CWD prion in bodily fluids and excrement, contaminating the environment and creating an agricultural and ecological calamity. Preclinical antemortem CWD testing method is …
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Chronic wasting disease as a model for the development of risk communication using the mental models approach
<p>Using chronic wasting disease (CWD) as a model for risk communication development using the mental models approach, this dissertation examines: 1) how published CWD risk communications compare to expert recommendations; 2) whether the experts and members of relevant stakeholder groups agree upon …
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Soil PH and clay content associated with chronic wasting disease in white-tailed deer in northern Illinois
Soil is an important reservoir for chronic wasting disease (CWD) which is a prion disease that infects cervids through both direct contact with infected animals and contact with contaminated environments. I built a boosted regression tree model that accurately predicted (AUC = 0.954) the …
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Monitoring for Chronic Wasting Disease in Mule Deer and White-Tailed Deer at Wind Cave National Park: Investigating an Emerging Epizootic
Chronic wasting disease (CWD) has emerged as a disease of concern in cervid populations. Testing, transmission, and detection of CWD are areas of interest for managing populations of North American deer (Odocoileus). This dissertation addresses these areas with research from data collected on mule …
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Characterizing U.S. Agency Approaches to Cervid Carcass Disposal in the Context of Chronic Wasting Disease Management: A Multi-State, Mixed-Methods Analysis
Chronic wasting disease (CWD) prions are notoriously resilient infectious agents that can retain infectivity in environmental settings for extensive periods of time. Given their pronounced durability and evidence of widespread prion distribution across an array of host tissues, the carcasses of …
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Exploring Novel Immunodiagnostics for Prion Disease
Prion Diseases, or Transmissible Spongiform Encephalopathies (TSEs), are rapidly progressive and fatal neurodegenerative diseases of mammals. TSEs of global importance include Creutzfeldt-Jakob Disease (CJD) in humans, Chronic Wasting Disease (CWD) in cervids, and Bovine Spongiform Encephalopathy …
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Development of a SNP Assay for the Differentiation of Allelic Variations in the mdx Dystrophic Mouse Model
… dystrophy (DMD), a severe and fatal muscle wasting disease. To evaluate possible treatments and to carry out genetic studies, it is essential to distinguish between mice that carry the mutant dystrophic or wt allele(s). The current Amplification-Resistant Mutation System (ARMS) assay used to …
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Caloric requirements in the hemodialysis subject
… on hemodialysis. Renal failure has been called a wasting disease as evidenced by decreased body weight, body fat, arm circumference and serum proteins. This research was designed to help precisely define energy requirements for the hemodialysis subject. Resting energy expenditure (REE) was …
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Use of the Protein Misfolding Cyclic Amplification for food safety and drug discovery
<p>Prion diseases are fatal neurodegenerative disorders caused by the misfolding of the normal prion protein (PrP<sup>C</sup>) into its infectious form (PrP<sup>Sc</sup>). While the zoonotic potential of chronic wasting disease (CWD) remains uncertain, the presence of prions in food products raises …
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The role of stress-derived vesicles in the bystander effect and cancer related cachexia
… numerous processes within the body, including in disease. One interesting function of EVs appears to be the induction of the bystander effect. The bystander effect refers to the non-targeted effects of stress, whereby stressed cells induce damage in neighbouring cells. EVs released from cells …
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Landscape genetics and CWD in white-tailed deer
… population structure in the context of chronic wasting disease transmission and spread. Chronic wasting disease is an infectious prion encephalopathy in cervids that is endemic to Colorado and Wyoming but has spread across the US within the last decade. Quantifying white-tailed deer movement and …
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Metabolic Profiling of Prions In The Gastro-Intestinal Tract
… <p><strong>Abstract</strong></p> <p>Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are a group of debilitating neurodegenerative disorders that affect both humans and animals. They can be spread by horizontal transmission as seen in chronic wasting disease …
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