Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"vorinostat"”.
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… with flowcytometry were also studied. </p> <p>Vorinostat, a pan HDAC inhibitor, independently induced significant neurite outgrowth in NS-1 cells, similar to that of NGF. The inhibitors of MEK1/2 & PI3K attenuated the NGF and vorinostat mediated neurite outgrowth. Vorinostat induced …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… benefit. Indeed, we found that cotreatment of vorinostat and cisplatin synergistically enhanced apoptosis and reduced long-term clonogenic survival. Furthermore, apoptosis arising from vorinostat and cisplatin co-treatment was FLIPs- and caspase-8-dependent.<br/><br/> TRAIL is an anti-cancer …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
… agent). The combination of two different HDACi (vorinostat or entinostat) with adaphostin synergistically induced apoptosis in ALL. This synergistic effect was blocked when cells were pre-treated with the caspase-9 inhibitor, LEHD. In addition, we showed that loss of the mitochondrial membrane …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… BTZ or MRZ and the histone deacetylase inhibitor vorinostat. Together, this data clarifies the optimal strategy for proteasome targeting in GBM, clarifies the hierarchy of caspase induction by proteasome inhibitors, and provides evidence that proteasome inhibitors can reach brain tumors where they …
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AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma
… strategies were tested: radiation with vorinostat (RT+Vor, epigenetic therapy) in 2D cultures using U87 and T98G cell lines, radiation with lenalidomide (RT+Len, immunotherapy) in 3D spheroids, and temozolomide with graphene quantum dots (TMZ+GQD). Microscopy images at 24 and 48 hours …
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Analysis of Out-of-Pocket Expenditures of Oral Oncologics for Tennessee Recipients of Medicare Part D
… sorafenib, erlotinib, dasatinib, sunitinib, vorinostat, nilotinib, and lapatinib, the annual out-of-pocket costs for each drug varied from $0 to a maximum of $1,133, based on plan design. Bivariate regression analysis showed that monthly premiums, deductibles, and cost-sharing are all precise …
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Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer.
… the action of paclitaxel, carboplatin, and vorinostat through an as yet undetermined mechanism. In a responsive cell line, dsRNA produced a synergistic effect when combined with these drugs. These novel dual therapies, innate immune ligand plus cytotoxic agent, may find application in …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… cells then the clinical approved HDAC inhibitor Vorinostat. The imidazoles also exceeded the antimetastatic in vitro acitivity and the antiangiogenic in vivo activity of Vorinostat. Like the latter, the best derivatives were shown to act as so called pan-HDAC inhibitors with unspecific inhibition …
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The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer
… of the histone deacetylase inhibitor, SAHA (Vorinostat™), and chemotherapeutic agents Doxorubicin, and Paclitaxel. Stable MBD2 knockdown in MCF7 cells led to an increased proportion of normal epithelial structures in 3D culture (70%, [CI=0.55-0.83]) when compared to untransfected (46%, …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… curcumin and two well-known HDAC inhibitors (vorinostat and panobinostat), have been tested. Curcumin, a natural polyphenol, has been described to exhibit effects on signaling pathways, leading to induction of apoptosis. In this study, we observed that curcumin inhibited Hsp90 activity causing …
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Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors
… FDA approved histone deacetylase inhibitor SAHA (Vorinostat) caused dose-dependent upregulation of <em>Notch1</em> expression and a parallel decrease in viability in these cells. Retroviral silencing of downstream targets of Notch with dominant negative <em>Hes-1 </em>as well as pharmacological …
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Role of epigenetics in hematopoietic stem cell development
… I histone deacetylase, or HDAC, inhibitor) and vorinostat (general HDAC inhibitor), were found to decrease HSC formation in zebrafish. The overall findings of this study provide insight into specific epigenetic regulators in HSC development and identify particular epigenetic markers that could …
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The structural requirements of histone deacetylase (hdac) inhibitors: suberoylanilide hydroxamic acid (saha) analogues modified at c3, c6, and c7 positions enhance selectivity
… drug suberoylanilide hydroxamic acid (SAHA, Vorinostat), have cleared clinical trials and emerged as anti-cancer drugs. However, SAHA inhibits all of the 11 metal ion-dependent HDAC proteins. Therefore, we synthesized several libraries of small molecule HDAC inhibitors based on SAHA to help …
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Computational and Pharmacological Characterization of HDAC6 Inhibition and Function
… inhibit HDAC6. These include Trichostatin A and Vorinostat. Recently there has been a drive towards HDAC6 specific inhibitors due to its presence in these diseases. These inhibitors include Nexturastat A and Ricolinostat (ACY-1215). Within this thesis these four inhibitors have been used …
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Nouvelles combinaisons thérapeutiques pour améliorer l'efficacité anti-tumorale de l'inhibition d'HDAC5
… hématologiques. A ce jour, 4 de ces molécules (Vorinostat®, l’Istodax®, Beleodaq® et le Farydak®) sont d’ailleurs approuvées par la FDA et l’EMA pour le traitement de patients souffrant, notamment, de différents types de lymphomes et de myélomes. Aujourd’hui, les oncologues s’intéressent au …