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Showing 1 to 20 of 48 for “"von Willebrand factor"”.
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Aberrant and Alternative Splicing of von Willebrand Factor
von Willebrand disease (VWD) is the most commonly inherited bleeding disorder in humans resulting from quantitative deficiencies or qualitative defects of von Willebrand factor (VWF). VWD can be caused by a variety of mutations throughout the VWF gene, the majority of which are missense changes. …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
von Willebrand factor (VWF) is a multimeric glycoprotein mainly known to be involved in primary hemostasis recruiting platelets at the site of damaged vessels and acting as factor VIII (FVIII) carrier. Quantitative or qualitative alteration of VWF protein is responsible for von Willebrand disease …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
von Willebrand Factor (VWF) is a large multimeric glycoprotein with important procoagulant roles in the circulation, including mediating platelet adhesion at sites of vascular injury and stabilizing Factor VIII in the plasma. VWF expression and activity is critically regulated to protect against …
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Understanding the Role of von Willebrand Factor (VWF) in Angiogenesis and Angiodysplasia
von Willebrand factor (VWF) is a large multimeric glycoprotein essential for hemostasis, mediating platelet adhesion to sites of vascular injury and stabilizing coagulation factor VIII (FVIII) in circulation. Deficiency or dysfunction of VWF results in von Willebrand disease (VWD), the most common …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
… by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF and platelets in high shear thrombosis, the present work developed a microfluidic thrombosis assay to meet low blood volume requirements and fluid shear conditions …
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Characterization of platelet glycoprotein Ib-IX-V: von Willebrand factor interaction under shear conditions
… between platelet glycoprotein (GP) Ib and von Willebrand factor (VWF). In the first part of the work, we evaluated the kinetics of interaction between platelet GP Ib-IX-V complex and VWF under arterial flow conditions. The GP Ibalpha subunit of GP Ib complex binds to VWF through the Al …
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von Willebrand factor interaction with subendothelial collagens and platelet surface receptor GPIBalpha under shear conditions
… mechanisms of binding interaction among von Willebrand factor, subendothelium and platelets under physiological shear conditions are important medically in hemostasis and thrombosis. By binding both subendothelial collagens and platelet surface receptors GPIbalpha, multimeric vWf acts as …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF …
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
… a basic helix-loop helix (bHLH) transcription factor, was previously shown to be regulated by iron loading however its precise role in iron metabolism was unknown. The studies presented in this thesis identified hepatic ATOH8 mRNA and protein expression to be robustly downregulated in various …
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Effects of nutrition and ultrasound imaging on the cardiovascular system
… for measurement of one of the biomarkers, von Willebrand Factor (Chapter 2). Effects of contrast ultrasound on von Willebrand Factor and atheroma thickness were observed. Next, another rabbit study was performed to assess the effect of contrast ultrasound on Hsp70, a cellular stress …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… of thrombus resolution. Identifying genetic risk factors for CTEPH would provide important insights into pathobiology and might allow risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million …
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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
<p>von Willebrand Disease (vWD) is a bleeding disorder caused by a deficiency in von Willebrand Factor (vWF), a large glycoprotein that assists in coagulation. Specifically, large vWF multimers in the blood stream are key components in starting the coagulation cascade. vWF is cleaved by the …
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Multi-scale computational modeling of particle adhesion dynamics under shear flow
… simulation, a physical description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) and platelet-aggregate morphology. It describes …
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Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated with G-CSF (+G-CSF …
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Effect of Levothyroxine Administration on Hemostatic Analytes in Doberman Pinschers with von Willebrand's Disease
… levothyroxine supplementation increases plasma von Willebrand factor (vWf) concentration and enhances vWf function. The effects of levothyroxine administration were evaluated in 8 euthyroid Doberman Pinschers with plasma vWf concentration <30%. Levothyroxine (0.04mg/kg PO q12hours) and placebo …
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Platelet Function in Dogs with Chronic Liver Disease
… decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. Hypothesis: Dogs with chronic liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal bleeding time (BMBT), and increased …
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Use of an Inducible Promoter to Characterize Type IV Pili Homologues in Clostridium perfringens
… on agar plates, and the PilA3 mutant lacked a von Willebrand factor A domain-containing protein in its secretome. We used our promoter system to express GFP-tagged versions of the TFP ATPase homologues and view them in cells growing on surfaces. We saw that PilB1 and PilB2 co-localized nearly …
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Polymers and colloids in flows : from dynamics to self-healing
… by ow, a blood-clotting protein (the so-called von Willebrand factor or vWF) can change shapes from a compact structure to an extended morphology. This polymeric protein later on forms composites with the colloidal cells (platelets) and completes the initial blood-clotting task. In this thesis, …
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The Influence of Resistance Training on Primary Hemostatic Responses
… Blood samples were analyzed for platelet count, von Willebrand Factor (vWF), Beta Thromboglobulin (β-TG) and Platelet Factor 4 (PF4).<strong>Results:</strong> Results found significant differences between the RT group and the UT group for measurements of plasma β-TG. Platelet count, vWF and β-TG …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF …
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