Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"voluntary wheel running"”.
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
… This study aimed to investigate the effect of voluntary wheel running (VWR) in ovariectomized (OVX) mice on whole body energy expenditure and body composition, key protein markers of thermogenesis and adipose tissue browning, and fluctuations in circulating and AT BDNF and receptor content. It …
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Voluntary wheel running mitigates hyperglycemia-induced depressive-like behavior and increases hippocampal BDNF levels in male mice.
… weeks post-STZ, mice in the exercise group had voluntary running wheel access in their home cage for 6 weeks. As anticipated, STZ induced depressive-like behavior. Exercise attenuated behavioral deficits in the forced swim and splash test. Tissue analyses found that exercise affected hippocampal …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… these studies was to investigate the effects of voluntary wheel running and forced treadmill running on lipopolysaccharide (LPS) and Bacillus Calmette-Guérin (BCG) induced sickness behavior (food intake, fluid intake, body weight, locomotor activity), depressive-like behavior (tail suspension …
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Effects of the gut microbiota and dietary inulin on age associated inflammation, endurance training adaptations, and voluntary wheel running motivation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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The Majority of the Diaphragm Immune Transcriptome Profile Rescued in Mdx Mice by Microdystrophin Gene Therapy was maintained by Voluntary Wheel Running
… microdystrophin gene therapy with and without running wheel activity. Mdx mice are a model of Duchenne Muscular Dystrophy (DMD). Similar to DMD, mdx pathophysiology is associated with chronic inflammation due to sarcolemma fragility and cellular membrane leakage. Immune modulation has not yet …
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The Effects of Chronic Stress and Exercise on Mouse Pancreatic Islet of Langerhans Morphology and Muscle Atrophy Gene Expression
… effects of chronic stress in combination with voluntary wheel running on murine islet morphology and skeletal muscle atrophy. The purpose of this study was to evaluate the effects of chronic stress and voluntary wheel running on murine beta cell number per Islet, insulin positive area in the …
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Effects of exercise and phytoestrogens on white adipose tissue health in estrogen deficient rodents
… WAT underlying mechanisms to determine how voluntary wheel running (Chapter 3) or a diet rich in phytoestrogens (SOY) (Chapter 4) can improve WAT health following OVX in rodents. Female OVX rats selectively bred for high (HCR) or low (LCR) intrinsic aerobic capacity were fed a high fat diet …
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The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
… of these rats is their intrinsic aptitude for voluntary wheel running despite their obesity. OLETFs were randomly divided into 4 groups (n=8/group): 1) remained sedentary 2) access to running wheels (3) diet supplemented with 3% of energy from fish oil and 4) access to running wheels and diet …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… BALB/c mice. The exercise intervention (voluntary wheel running) was designed to mimic four clinically relevant scenarios: 1- patients who are sedentary before and after diagnosis, 2- previously sedentary patients who begin exercising after diagnosis, 3- previously active patients who …
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The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
… contraction modalities were pursued, focusing on voluntary wheel running, forced treadmill training, and in vivo electrical muscle stimulation. Overall, this study introduces a novel muscle-specific TLR4 knockout mouse model and discloses a crucial role for mTLR4 in basal systemic cytokine …
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Potential adaptive signaling pathways in the diaphragm of mdx mice treated with micro-dystrophin combined with voluntary running
Hamm et al., 2021 reported that voluntary wheel running (R) was complementary to micro-dystrophin gene therapy (GT) in mdx mice, a model of Duchenne muscular dystrophy (DMD). After 21 weeks of running, time to fatigue on a treadmill for the mdxRGT mice was increased 1.8-fold compared to mdxGT mice …
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Effects of 5-Fluorouracil Chemotherapy On Fatigue and Inflammation In Mice: Benefits of Quercetin
… the effect of chemotherapy alone on 24 hr voluntary wheel running activity in healthy mice, as well as to determine the potential role of inflammatory cytokines and the potential benefits of quercetin supplementation. C57BL/6 mice were assigned to one of four treatments: placebo (PBS), low …
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Exploring the effects of maternal immune activation on cisplatin-induced toxicities.
… six weeks old, offspring were single housed with running wheels and 14 days later were injected with saline or cisplatin (2.3 mg//kg/day for 5 days). After cisplatin treatment, mice underwent a battery of affective tests. MIA females showed increased voluntary wheel running compared to controls, …
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Investigating The Role Of Transient Receptor Potential Ankyrin One (TRPA1) In Cardiovascular Regulation
… phenotype, measured by both telemetry and voluntary wheel running. 14 day infusion of angiotensin II by osmotic minipump induced similar hypertension in both TRPAl WT and KO mice. Hypertrophy of the heart was seen in both genotypes, but of significantly increased magnitude in TRPAl KO mice. …
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Physiological adaptations in mdx mice treated with microdystrophin gene therapy and endurance exercise
… gene therapy with and without 21 weeks of voluntary wheel running (VWR) improved treadmill time to fatigue and in vivo plantarflexor torque output in young mdx mice, a mouse model of DMD. Although treated mice could run well, diaphragm force and power output were blunted by VWR. A …
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Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
… Given these findings, we hypothesized that voluntary wheel running or an acetylcholinesterase inhibitor donepezil treatment, started before neuromuscular decline, would delay neuromuscular impairment in 5xFAD mice. Using 3-month-old 5xFAD and wild type (WT) littermates, we provided voluntary …
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The effect of voluntary exercise on adult hippocampal neurogenesis in maternally separated rats
… in neurogenesis may be a key-mediating factor. Voluntary wheel running is a form of exercise that increases neurogenesis and decreases depression-like behaviour in rats. However, the exact molecular role of neurogenesis in exercise-induced antidepressant effects still remains unanswered. This …
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Ovarian hormones, but not androgens, mediate running-induced changes in high fat diet choice patterns in rats
… using a two-diet choice (chow vs. HF) and voluntary wheel running paradigm found that upon simultaneous introduction of a novel HF diet and wheel running, male rats show complete and persistent HF diet avoidance whereas the majority of females reverse HF diet avoidance. Ovariectomy (OVX) …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
… of hippocampal inhibitor-1 were increased by voluntary wheel running, a stimulus for neurogenesis. Thus, inhibitor-1 may function in an anti-neurogenic mechanism and be more important in the direct or indirect modulation of dopamine-dependent behaviors than in the mnemonic functions of the …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… individually housed in a cage equipped with a running wheel for a period of seven acclimation days, three baseline days, and seven post days after 3-time intraperitoneal (i.p.) injections of either sterilized saline (sPBS) or MCP-1 (5ug/mouse/day). Their voluntary wheel running activities were …
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