Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"voltage-gated sodium channels"”.
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Modeling of Electrostatic Interactions inside Human Voltage-Gated Sodium Channels
… we focus on the permeation of Na+ through human voltage-gated sodium channels (Navs). Despite their biological significance, the selective permeation mechanism of Nav channels remains poorly understood at the molecular level. Here, we calculated electric fields inside the channel pore of Nav1.5, …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
Voltage-gated sodium (Nav) channels are responsible for initiation and propagation of action potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with a wide range of brain disorders including psychological, neurological and …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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A single molecule study on the structural basis of ion selective permeation in voltage-gated sodium channels
High resolution studies of voltage-gated sodium channels (VGSCs) can not reveal the dynamic nature of the channel structures, especially in lipid environments, which are vital for rational drug design. The bacterial NavAb channel is highly like its eukaryotic orthologs in structure, function, and …
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Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators
… have evolved resistance through mutations in voltage-gated sodium channels, the protein targets of tetrodotoxin, sparking an evolutionary arms race between predator and prey. In this dissertation, I describe how genomic rearrangements have led to sex-linkage of four of the voltage-gated sodium …
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Characterization of the mechanisms behind the alternative splicing of the mutually exclusive exons 18N and 18A in the sodium channel gene SCN8A and mutually exclusive exons 5N and 5A in the soldium channel gene SCN9A
Voltage-gated sodium channels are the primary molecules responsible for the rising phase of action potentials in electrically excitable cells. There are 10 distinct sodium channel isoforms Na<sub>v</sub> 1.1-1.8 (SCNIA-SCN5A and SCN8A-SCNIIA) and the majority of these undergo tissue and …
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Structural and functional characterization of signaling protein complexes
… sensitivity when bound to its substrates. All voltage-gated sodium channels possess the IQ motif for binding to calmodulin but are each differently regulated. Through biophysical and computational analyses, the mode of calmodulin binding to two high affinity sodium channel isoforms Nav1.4 and …
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
Voltage-gated sodium channels (Navs) are responsible for the upstroke of action potentials in electrically excitable cells. Transmission of nociceptive information from the body periphery to the central nervous system is mediated by specific isoforms of Navs present in dorsal root ganglion (DRG) …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
Voltage-gated sodium channels are composed of pore-forming α-subunits, and modulatory and multifunctional associated β subunits. While much of the field of cardiac electrophysiology and pathology has focused on treating and preventing cardiac arrhythmias by targeting the α subunit, there is also …
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The Relationship between Ephaptic Coupling and Excitability in Ventricular Myocardium
… threshold and subsequent recruitment of voltage gated sodium channels to trigger an action potential. Conduction in cardiomyocytes is dependent on the robustness and speed of action potential propagating through tissue. Both are equally important for normal heart function and claim to be …
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Mechanisms and plasticity of cold sensitivity in peripheral neurons
… receptor potential (TRP) family of cation channels are currently recognised as the principal transducers of thermal stimuli in sensory neurons, and two channels, TRPM8 and TRPA1, have been implicated in cold sensation. Ratiometric calcium imaging and quantitative rt-PCR studies revealed …
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The Diversity of FHF-mediated Ion Channel Regulation
… family (FGFs, FGF11-FGF14) that bind directly to voltage gated sodium channels (VGSCs), thereby regulating channel activity and consequently neuronal excitability. Mutations in FGF14 cause spinocerebellar ataxia while FGF13 is a candidate for X-linked mental retardation. Since FGF13 and FGF14 are …
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The Role of Sulfatide in Alzheimer's Disease
… formed and are unstable. In these ST null mice, voltage gated sodium channels, neuronal proteins that normally cluster at the nodes of Ranvier, initially accumulate in the node but are not retained with age. Taken together the findings from the ST null mice indicate that membrane organization is …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… potential. The AIS contains a high density of voltage-gated sodium channels, the fundamental component of the neuron driving the initiation and propagation of the action potential, which interact with accessory and regulatory proteins including ankyrin-G, β-IV-spectrin, neurofascin, and …
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Studies on voltage-gated sodium channel β3 subunit structure and cancer-related functions using single-chain variable fragment antibodies and bioinformatics
Voltage-gated sodium channels (VGSC), embedded in the plasma membrane of cells, play a pivotal role in generating sodium currents and action potentials. The mammalian VGSCs consist of a large pseudo-tetrameric pore-forming α subunit, the channel protein, which associates with one or more …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …
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The Role of Sulfatide in the Development and Maintenance of the Nodal and Paranodal Domains in the Peripheral Nervous System
… adult mice. Whereas nodal clustering of neuronal voltage-gated sodium channels is initially normal, cluster number is significantly but also transiently reduced by 7 days of age. By 10 months of age, the number of sodium channel clusters is restored to normal levels. In contrast, clustering of …
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A Biochemical And Pharmacological Characterization Of A Novel Neuroactive Peptide From The Neotropical Hunting Ant Dinoponera Australis
… peptide also has a minor inhibitory effect on voltage-gated sodium channels, which does not contribute to the depolarization. Membrane assays with microsomes, fluorescent probes and lipid bilayers confirmed peptide-induced non-selective and concentration dependent permeabilization of the …
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Evolutionary Patterns of Avian Tetrodotoxin Resistance
… of Tetrodotoxin-Binding Sites in Avian Naᵥ Channels Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (Naᵥ), inhibiting nerve and muscle function. Some species possess TTX as an anti-predator defense, and some predator species have evolved resistance to TTX …
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