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Showing 1 to 20 of 23 for “"voltage-gated sodium channel"”.

  1. Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue

    Goode, Nana AboadweThe University of Texas Medical Branch at Galveston2023

    Voltage-gated sodium (Nav) channels play a critical role in the initiation and propagation of action potentials in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they …

    utmb Repository record

  2. VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS

    COLOMBO, MARIA NICOLUniversità degli Studi di Milano2022

    Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …

    milano Repository record

  3. The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart

    Williams, Zachary JamesVirginia Tech2024

    Voltage-gated sodium channels are composed of pore-forming α-subunits, and modulatory and multifunctional associated β subunits. While much of the field of cardiac electrophysiology and pathology has focused on treating and preventing cardiac arrhythmias by targeting the α subunit, there is also …

    vt Repository record

  4. Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions

    Wadsworth, Paul AThe University of Texas Medical Branch at Galveston2020

    As fundamental determinants of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is associated with disorders ranging from neurological (i.e., epilepsy, …

    utmb Repository record

  5. Voltage-Gated Sodium Channel Activity in Mouse Skeletal Muscle Fibers: Normal Gating and Defects Associated with Periodic Paralysis Mutants

    Fu, Yu2010

    … SCN4A, the gene encoding the skeletal muscle Na+ channel (NaV1.4) α-subunit, cause several disorders related to skeletal muscle excitability. The functional consequences of these NaV1.4 mutations have been extensively characterized in heterologous expression systems. These studies have …

    utswmed Repository record

  6. Studies on voltage-gated sodium channel β3 subunit structure and cancer-related functions using single-chain variable fragment antibodies and bioinformatics

    Liu, HengruiUniversity of Cambridge2024

    Voltage-gated sodium channels (VGSC), embedded in the plasma membrane of cells, play a pivotal role in generating sodium currents and action potentials. The mammalian VGSCs consist of a large pseudo-tetrameric pore-forming α subunit, the channel protein, which associates with one or more …

    cambridge Repository record

  7. Diverse Mechanisms Impair Thalamic Circuit Function in a Dravet Syndrome Mouse Model

    Studtmann, CarleighVirginia Tech2022

    … mutations in the SCN1A gene, which encodes the voltage-gated sodium channel, NaV1.1. Haploinsufficiency of NaV1.1 in DS patients leads to imbalanced excitability across brain circuits, resulting in a broad phenotypic profile including drug-resistant convulsive and non-convulsive (absence) …

    vt Repository record

  8. The role of the perinexus in Long QT Syndrome Type 3

    Wu, XiaoboVirginia Tech2023

    Gain of function of cardiac voltage-gated sodium channel (Nav1.5) leads to Long QT Syndrome Type 3 (LQT3). LQT3 phenotype can be exacerbated by expanding the perinexus, which is an intercellular nanodomain with high density of Nav1.5 in the intercalated disc. Following this finding, we found that …

    vt Repository record

  9. Naᵥ1.8+ Visceral Afferent Neurons: Roles in Metabolism and Inflammation

    Udit, Swalpa 1985-2016

    … Cre recombinase under the control of Naᵥ1.8, a voltage gated sodium channel present only in peripheral sensory neurons, including 80% of vagal sensory afferent neurons Metabolic phenotyping of these ablated mice in comparison to control littermates did not reveal differences in body weight or …

    utswmed Repository record

  10. INTERNEURON TRANSPLANTS AS A TREATMENT FOR SEIZURES AND SOCIAL DEFICITS IN A MOUSE MODEL OF DRAVET SYNDROME

    Sotuyo, Nathaniel2024

    … function variants in SCN1A, which codes for the voltage-gated sodium channel  subunit Nav1.1. DS is also characterized by high rates of autism spectrum disorder and intellectual disability. In this dissertation, we first review the role of interneuron dysfunction in DS, and we review the …

    penn Repository record

  11. Exploring Pain Neurobiology: Molecular Investigation of Genetic Sensory Disorders

    Sarveswaran, NiveditaUniversity of Cambridge2021

    … representing localised structural changes to the voltage-gated sodium channel (VGSC) Nav1.7. Studies revealed that all mutants were non-conducting, independent of protein folding or membrane trafficking defects, implying critical intramolecular roles for the affected residues. Through this project …

    cambridge Repository record

  12. Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System

    Faggins, AthenesiaTemple University. Libraries2013

    … suggest miR-184 targets (i) paralytic (para), a voltage-gated sodium channel, shown to control neuronal excitability; and (ii) tramtrack69 (ttk69), a transcription factor known to regulate glial cell number and fate determination during embryonic development. In the absence of miR-184, homozygous …

    temple Repository record

  13. Adaptive evolution, sex-linkage, and gene conversion in the voltage-gated sodium channels of toxic newts and their snake predators

    Gendreau, KerryVirginia Tech2022

    … have evolved resistance through mutations in voltage-gated sodium channels, the protein targets of tetrodotoxin, sparking an evolutionary arms race between predator and prey. In this dissertation, I describe how genomic rearrangements have led to sex-linkage of four of the voltage-gated sodium …

    vt Repository record

  14. Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking

    Dustrude, Erik Thomas2015

    The voltage-gated sodium channel Nav1.7 has gained traction as a pain target with recognition that loss-of-function mutations in SCN9A, the gene encoding Nav1.7, are associated with congenital insensitivity to pain, whereas gain-of-function mutations produce distinct pain syndromes due to increased …

    iupui Repository record

  15. Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity

    Song, Weihua2012

    The cardiac voltage-gated sodium channel α subunit Nav1.5 generates the cardiac sodium current, which is essential for the initiation and propagation of the cardiac action potentials. Mutations of SCN5A, the gene that encodes Nav1.5, have been well documented to cause long-QT syndrome (LQTs) by …

    iupui Repository record

  16. Anti-GD1a antibody targeted disruption of the node of Ranvier in a mouse model of acute motor axonal neuropathy

    McGonigal, RhonaUniversity of Glasgow2009

    … to immunostaining for nodal protein’s including voltage gated sodium channel and ankyrin G. This is indicative of targeted injury to this region of the distal axon in an acute model. The loss of nodal protein staining is associated with the activation of complement and the Ca2+-dependent protease …

    glasgow Repository record

  17. CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL

    Alshammari, Musaad AliThe University of Texas Medical Branch at Galveston2021

    … Thus, I examined a key element of the AIS, the voltage-gated sodium channel 1.6 (Nav1.6) α-subunit––an ion channel responsible for generating and propagating action potentials in mature neurons. My observations revealed a significant decrease in the Nav1.6 axonal expression level in the DG of …

    utmb Repository record

  18. Evolutionary Patterns of Avian Tetrodotoxin Resistance

    Shahnam, Cyrus AlexanderVirginia Tech2026

    … of Tetrodotoxin-Binding Sites in Avian Naᵥ Channels Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (Naᵥ), inhibiting nerve and muscle function. Some species possess TTX as an anti-predator defense, and some predator species have evolved resistance to TTX …

    vt Repository record

  19. Investigation of the roles of ion channels in the development of the sea urchin embryo

    Thomas, Christopher Farzad2023

    Ion channels and pumps play critical roles during sea urchin development including mediating the blocks to polyspermy, regulating left-right and dorsal-ventral axis specification, directing ventral PMC migration, and controlling biomineralization of the larval skeleton. We performed a screen of …

    bu Repository record

  20. Structural and functional characterization of signaling protein complexes

    NG CHERLYN2009

    … sensitivity when bound to its substrates. All voltage-gated sodium channels possess the IQ motif for binding to calmodulin but are each differently regulated. Through biophysical and computational analyses, the mode of calmodulin binding to two high affinity sodium channel isoforms Nav1.4 and …

    nus Repository record

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