Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"voltage-gated calcium channels"”.
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… present mutations in genes that encode different voltage-gated calcium channels, a class of ion channel that are important players in pain pathways. Among them, mutations in the genes CACANA1A, CACNA1G, and CACNA1H, that encode CaV2.1, CaV3.1 and CaV3.2 channels, respectively, were investigated. …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
T-type voltage-gated calcium (Ca2+) channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. …
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Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… by preventing glucose-associated alterations of voltage-gated calcium currents (VGCC) in small diameter dorsal root ganglion (DRG) neurons. Using behavioral, nerve-electrophysiology and patch-clamp methodology we examined the functional consequences of forced-exercise (treadmill, 5.4 km/week) on …
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IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
… by Ca 2+ influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key functional role for Ca v 3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC - specific AM RF EMF.
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
Voltage-gated calcium channels play a vital role in triggering the vesicle release in presynaptic terminals. We have identified several molecules in modulating the calcium channel functions. One of our focus is snapin from presynaptic complex, and the other is gangliosides and anti-gangliosides …
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Assessing Crosstalk Between Calcium and cAMP in Pancreatic Alpha Cells
… ultimately requires an increase in cytosolic calcium. This study focused on the link between cyclic AMP and calcium in pancreatic alpha cells which allows alpha cell regulation. Interactions between calcium and cyclic AMP in pancreatic alpha cells consists of PKA-dependant and PKA-independent …
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Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
… using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
L-type (CaV1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 …
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Learning and cemory in the cav1.2 knockout mouse
… many signaling pathways found within neurons, calcium signaling is perhaps the most ubiquitous and versatile. Calcium influx through L-type voltage-gated calcium channels (L-VGCCs) is involved in numerous aspects of neuronal function: activation and regulation of gene transcription, synaptic …
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Divalent Effects on Permeatin and Gating of T-type calcium channels
… ion composition and their membrane potential. Voltage gated calcium channels change both of these properties by allowing Ca2+ to enter the cell, causing membrane depolarization and the entry of Ca2+ which acts as important signaling molecule. Much research over the last few decades has gone …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
… It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis continues still. The goal of this thesis is to take a bottom up approach to …
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The molecular and behavioral characterization of cav1.3 over-expressing mice
… that a dysregulation of neuronal intracellular calcium concentration contributes to age-related cognitive deficits. Previous research suggests that an increase in neuronal L-type voltage-gated calcium channels (LVGCCs) occurs in the brain during aging. This increase could account for altered …
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Calcium Channel Gamma(6) Subunit: In Search of Its Functions and Mechanisms of Action
Voltage-gated calcium channels contain a pore-forming alpha1 subunit and auxiliary alpha2delta, beta and gamma subunits. Of the three auxiliary subunits, gamma is least understood. Cardiac myocytes express three gamma isoforms: gamma4, gamma6 and gamma 7. Low-voltage activated (LVA) calcium …
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Novel Effects of Simvastatin on Uterine Fibroids
… manner mechanistically dependent upon apoptotic calcium release from L-type voltage-gated calcium channels. Thus, simvastatin possesses anti-tumor effects which are dependent upon the apoptotic calcium release machinery. For the in vivo studies, animals were treated with simvastatin vs vehicle …
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Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey
… retraction appeared to be due, in part, to calcium influx via voltage-gated calcium channels, since application of high potassium media inhibited neurite outgrowth, an effect that was blocked by Co²+ or Cd²+. Glutamate application in the presence of [omega]-conotoxin MVIIC still inhibited …
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Modulatory effects of Cav1.3 calcium channels on dopamine homeostasis and alpha synuclein expression in a mouse model of Parkinson’s disease
… to be an important pathogenetic factor whereby calcium and α-synuclein (aSYN) pathology facilitate the selective death of substantia nigra neurons. The present study aimed at investigating the modulatory effects of the voltage-gated calcium channels of subtype 1.3 (Cav1.3) on dopamine (DA) …
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Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye
… increased Ca2+ influx through L-type voltage gated calcium channels (L-VGCCs) -- are believed to contribute to certain functional declines, but this possibility has not yet been tested in the neural retina. In young, mid- and old adult Long-Evans rats, we compared visual function …
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A quantitative study of neuronal calcium signaling
… Fast signals are communicated by transmembrane voltage changes, while calcium levels within the cell communicate information on a much slower time scale. Calcium acts as a second messenger responsible for modulating neuronal excitability in many ways including the mediation of gene transcription …
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Mechanisms Mediating Adaptive Presynaptic Muting Induction
… memory but susceptible to excitotoxic damage. Calcium serves as a signal transducer during excitotoxicity and many forms of synaptic plasticity, but the signaling cascades in presynaptic silencing were previously unknown. In neurons individually depolarized via heterologous ion channel …
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