Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"voltage-dependent gating"”.
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Voltage-dependent gating at the selectivity filter of the MthK K+ channel.
Voltage-dependent K+ channels can undergo a gating process known as C-type inactivation. This type of gating consists of entry into a nonconducting state that may involve conformational changes near the channel's selectivity filter. However, the details of the underlying mechanisms are not clear. …
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Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance
… channel conductance (γj), transjunctional-voltage dependent gating (Vj-gating) properties, and magnesium modulation. We investigate here how pore-lining residues may influence these GJ properties. We mutated putative pore-lining residues in Cx50 GJ (G8E/G46E/V53E individually or in …
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Characterization of cardiac IKs channel gating using voltage clamp fluorometry
Voltage-gated ion channels make up a superfamily of membrane proteins involved in selectively or non-selectively conducting charged ions, which can carry current in and out of cells, in response to changes in membrane voltage. Currents carried by ion channels influence the voltage across the cell …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… interaction between GD3 and mitochondrial voltage-dependent gating protein 1 (VDAC1). Subsequent VDAC1 activation and autophagic cell death was observed. Downregulation of VDAC1 ameliorated the cytotoxic effect of OSW-1 in melanoma, indicating that VDAC1 was critical to mediating OSW-1’s …
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VDAC and SOD1: two major players in mitochondrial metabolism and in ALS
… here has been devoted to two proteins, the Voltage-Dependent Anion Channel (VDAC) and the Superoxide Dismutase I (SOD1) and has been especially focused on the relationships between them in physiological or pathological conditions of the cell. VDAC is a pore-forming protein located in the …
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Lipid Chemistry and Mechanical State of the Membrane Modulate Ion Channel Function
<p>My research focused on voltage-dependent K<sup>+</sup> (Kv) channels. Kv channels serve many different functions in different cells, but most notably underlie action potentials in electrically excitable cells, such as neurons and muscle (Hodgkin and Huxley, 1952, 1945). Kv channel gating is …
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The Structural and Functional Analysis of a Voltage-Dependent Potassium Channel
<p>Voltage-dependent ion channels are finely tuned to open and allow ion conduction in response to changes in the membrane voltage, a function that lies at the heart of nerve impulse generation and propagation. These channels contain transmembrane voltage-sensing domains that contain highly …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
… pore domain potassium (K2P) channels, which are voltage- and time-independent channels that are constitutively open over the entire range of physiological membrane potentials. Heteromeric TASK-1/3 channels are critical to oxygen sensing in carotid body type 1 cells, where hypoxia-induced …