Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"voltage-dependent anion channel"”.
-
Magic angle spinning NMR applied to membrane protein 2D crystals : the structure and function of VDAC
… 32 kDa human integral membrane protein VDAC, the Voltage Dependent Anion Channel. Our results on VDAC have relied on a number of improvements in NMR methodology described in this thesis. These new methods include '3C-' 3C and 5N- 3C recoupling experiments optimized for measuring long-range …
-
Ankyrin Dependent Mitochondrial Function and Bioenergetics In The Heart
… encoded by <em>ANK2</em>, clusters relevant ion channels and cell adhesion molecules in several important domains; however, its role at Mitochondria Associated ER/SR Membranes (MAMs) has yet to be investigated. MAMs are crucial to mitochondrial function and metabolism and are signaling hubs …
-
Formazione di proteine canale: dal mitocondrio a SARS-CoV-2. Caratterizzazione funzionale e strutturale attraverso l'uso di tecniche respirometriche e di dinamica molecolare
… le principali porine riconosciute, vi è VDAC (Voltage Dependent Anion Channel), che tra le sue funzioni ha il trasporto di numerose molecole, tra cui ioni e metaboliti vari, tra cui composti vari coinvolti nei processi neurodegenerativi, come gli aggregati di α-sinucleina, principali …
-
VDAC and SOD1: two major players in mitochondrial metabolism and in ALS
… here has been devoted to two proteins, the Voltage-Dependent Anion Channel (VDAC) and the Superoxide Dismutase I (SOD1) and has been especially focused on the relationships between them in physiological or pathological conditions of the cell. VDAC is a pore-forming protein located in the …
-
Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
… (Hsc70), glutamate oxaloacetate 2 (GOT2) and voltage-dependent anion channel 1 (VDAC1) were validated as potential markers of MPTP-induced toxicity using western blot analysis. In parallel, a study of the mitochondrial phosphoproteome was undertaken. Despite the limitations of detection …
-
Caratterizzazione del ruolo della Superossido Dismutasi 1 (SOD1) in relazione al metabolismo mitocondriale
… svolge la funzione di difendere la cellula dall anione superossido. Nonostante siano state descritte 3 isoforme diverse, la Cu-Zn SOD, o SOD1 è l isoforma più abbondante nel citosol. Negli ultimi anni l interesse verso lo studio di questa proteina è cresciuto sempre di più, dal momento che …