Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"voltage gated calcium channel"”.
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Development of blocking antibodies to the voltage-gated calcium channel cav3.2
T-type voltage-dependent calcium channel Cav3.2 is a four-domain channel participating in various physiological and pathological processes principally in the nervous system but also in non-excitable cells. Upregulation of Cav3.2 or mutations in this channel are found in pain syndromes, certain …
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MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
Voltage-gated calcium channels play a vital role in triggering the vesicle release in presynaptic terminals. We have identified several molecules in modulating the calcium channel functions. One of our focus is snapin from presynaptic complex, and the other is gangliosides and anti-gangliosides …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
L-type (CaV1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 …
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The voltage gated calcium channel β2 protein is required in the heart for control of cell proliferation and heart tube integrity
L-type calcium channels regulate calcium (LTCC) entry into cardiomyocytes. CACNB2 (β2) LTCC auxiliary subunits traffic the pore-forming CACNA subunit to the membrane and modulate channel kinetics. β2 is a Membrane Associated Guanylate Kinase (MAGUK) protein. A major role of MAGUK proteins is to …
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IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
… by Ca 2+ influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key functional role for Ca v 3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC - specific AM RF EMF.
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Development of a flexible image-based approach for studying signal transduction in isolated arterioles
… leads to smooth muscle depolarization and voltage-gated calcium channel activation. A barrier to understanding the exact signaling events is the limited ability of glass electrodes to follow temporal changes in membrane potential (Em). This study aimed to develop an imaging station to …
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Gabapentin Discriminative Stimulus Effects
… seizures. Gabapentin is an inhibitor of the voltage gated calcium channel (VGCC) subunit α<sub>2</sub>δ-1. Due to its unique binding site, gabapentin is widely thought to have low abuse potential, and therefore has had increasing prescription rates. Increasing overall use of gabapentin has …
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Investigating the Role of R-type Channel Mutations in Developmental and Epileptic Encephalopathies
… been implicated is CACNA1E, which encodes the voltage-gated calcium channel Cav2.3 (R-type). Mutations in CACNA1E have been identified in patients with DEEs; however, the mechanisms by which these mutations affect channel function, and thus their relationship to DEEs, remain largely unknown. …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… The aberrant expression and function of ion channels in the oncology field has been increasingly recognised in genomic and laboratory studies in recent years. In PCa, it has been shown that the voltage-gated calcium channel CACNA1D gene, is upregulated in genomic analyses using clinical …
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Mechanisms of plasticity at the axon initial segment
… which acts downstream of L-type (Cav1) voltage-gated calcium channel activation. Moreover, calcineurin signalling is sufficient for AIS relocation. Whilst studying the timecourse of AIS relocation, I also discovered that the AIS is subject to a much more rapid form of plasticity. In …
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Non-Psychotropic cannabinoids attenuate visceral pain in colitis
… root ganglia neurons revealed CBD to act via a voltage-gated calcium channel with preliminary evidence indicating a high-voltage activated isoform. Preliminary data also suggest that the mixture of npCBs may act through a similar mechanism. These results suggest CBD, CBG, and a mixture of npCBs …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… VitD does however increase glucose-stimulated calcium uptake, suggesting that VitD affects transcription of genes involved in calcium flux into the beta cell. To identify molecular mechanisms linking VDR activity to increased insulin secretion and increased glucose-stimulated calcium uptake, we …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… and behavior. I thus first elucidated ASH calcium activation dynamics using simple step responses and using a newly developed systems identification approach for C. elegans. Using both long pulses and rapidly fluctuating "white noise" sequences of different nociceptive stimuli, I deduced …
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Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
… using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the …
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Characterization Of High-Voltage-Activated Calcium Channels In Retinal Bipolar Cells
… cell types and physiological properties. Voltage-gated Ca<sup>2+</sup> channels could be particularly important underlying the diversified physiological properties of different BCs. In this dissertation, I investigated the high-voltage-activated (HVA) calcium current in retinal bipolar …