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Showing 1 to 20 of 26 for “"vitamin K"”.
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Molekulare Ursachen Vitamin K-abhängiger Gerinnungsstörungen
Vitamin K ist ein essentieller Cofaktor für die posttranslationale Gamma-Carboxylierung von sog. Vitamin K-abhängigen Gerinnungsfaktoren, Knochenproteinen, Zellwachstum-regulierenden und weiteren Proteinen mit noch unbekannter Funktion. Defekte im Vitamin K-Stoffwechsel führen einerseits zu zwei …
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Hemorrhagic Diathesis in Rats: Effect of Strain, Estrogen, Testosterone, Vitamin K and Methionine
Made available in DSpace on 2014-12-05T22:04:02Z (GMT). No. of bitstreams: 1 6202936.pdf: 7338927 bytes, checksum: 9a64a892fa54955278caf3de871d04d3 (MD5) Previous issue date: 1962
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Discovery Of Inactive E* Conformations In Thrombin And Other Vitamin K- Dependent Clotting Proteases
… activity of serine proteases belonging to Vitamin K-dependent clotting factors is significantly affected by Na+ through an allosteric mechanism. Over the past 30 years, structural and biochemical studies revealed that Na+ enhances the enzymatic properties of these proteases from a low …
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The effect of vitamin K On vascular health and physical function in older people with vascular disease
… work has suggested that vitamin K, a known cofactor for coagulation proteins, may be required for the function of several other key proteins. In particular, Matrix Gla protein may exert beneficial effects on vascular health. I hypothesised that supplementation of the diet …
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Upstream and downstream issues in the production of recombinant vitamin K-dependent proteins in the milk of transgenic pigs
… for our work on the development of recombinant vitamin K-dependent protein production in porcine milk. This thesis contains the first collection of articles meant to specifically address issues that will affect FDA clinical trials and approval of recombinant VKD proteins from the milk of …
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Biochemie a patobiochemie fylochinonu a menachinonů
SOUHRN Vitamin K patří mezi poslední z lipofilních vitaminů, který není v klinických laboratořích rutinně stanovován. Vitamin K působí jako důležitý kofaktor posttranslační γ-karboxylace glutamové kyseliny u vitamin K dependentních proteinů (např. osteokalcin, koagulační faktory II, VII, IX, X). …
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Changes in Bone Mineral Density and Biomarkers of Bone Turnover with Calcium Supplementation During Initial Military Cadet Exercise Training
… study investigated the effect of a calcium, vitamin D, and vitamin K supplement combination during initial military cadet exercise training on: BMD, stress fracture occurrence, hormones associated with BMD, and biochemical markers of bone turnover. Significant changes in BMD, either between …
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Increasing Inclusion of Participants, Leveraging Gut Microbiomes, and Optimizing Machine Learning Models to Advance Warfarin Precision Medicine
… Anticoagulation therapy with the popular vitamin K antagonist, warfarin, can be challenging due to large interpatient dose variability and a narrow therapeutic window. Warfarin genotype-guided dose prediction models currently can account for approximately 50% of the total variability seen …
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Part I: Circular dichroism studies of optically active charge transfer complexes. Part II: vapor phase and solvent dependence circular dichroism studies of some terpenes, α-phenylethanol, and α-phenylethylamine
… spectra of the achiral acceptors TCNE, DDQ, and Vitamin K<sub>3</sub> with chiral donors such as terpenes, steroids and β-phenylethylamine derivatives in methylene chloride at 27° were investigated. A new transition not attributable to either component alone, but due to a CT complex was observed. …
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Fermentation of vitamin K2 (menaquinone-7): Development of an optimal fermentation process to selectively enhance the production of the biologically significant all-trans isomer
Vitamin K is a lipid-soluble vitamin first discovered in 1929 by the Danish nutritional biochemist Carl Peter Henrick Dam as an antihaemorrhagic factor capable of correcting dietary-induced bleeding disorders in chicks. The vitamin K family encompasses a series of structurally related compounds, …
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Disulfide Bond Formation: Identifying Roles of PDI Family Thiol Oxidoreductases and ER Oxidant Pathways
… ER oxidases, peroxiredoxin 4 (PRDX4) and Vitamin K epoxide reductase (VKOR), showed more modest effects. Upon co-depletion of Ero1 and other oxidases, additive effects were observed, culminating in cell death following combined removal of Ero1, PRDX4, and VKOR activities. These studies …
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Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.
Protein Z (PZ) is a vitamin k-dependent plasma glycoprotein produced mainly in the liver, which circulates as a complex with PZ-dependent protease inhibitor. Human PZ has been reported as having both procoagulant and anticoagulant activity, but its anticoagulant role appears to be more …
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Separation and quantification of fourteen chemical forms of fat soluble vitamins in food matrices using solid phase extraction coupled with liquid chromatography – mass spectrometry
… developed for separation and quantification of vitamin A (retinol, beta-carotene, retinyl-palmitate, retinyl-acetate), vitamin D (D2, D3), vitamin E (alpha,beta,gamma,delta tocopherols, tocopheryl-acetate), and vitamin K (K1, K2, K3) from different food matrices. The polarities of all fourteen …
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Assessing the Prevalence of Inadequate Nutrient Intake Among Vegetarians and Non-Vegetarians Using the Estimated Average Requirement : Results From the Adventist Health Study-2 Calibration Study
… Vegan were likely to be inadequate in vitamin E (71%), B12 (44%) and A (40%) while Vegetarians were inadequate in vitamin E (71%), A (30%) and magnesium (29%). Non-vegetarian were inadequate in vitamin E (91%), magnesium (50%) and folate (41%). Mean intake of calcium and vitamin D were …
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Evaluating Treatment of Antiphospholipid Syndrome during Pregnancy with Knowledge Synthesis Methods
… to manage APS. Next, I explored the use of vitamin k antagonists (VKAs) in pregnant women with APL using a scoping review approach, which are discontinued during the first trimester due to established teratogenicity. Finally, a systematic review was conducted to assess the pregnancy …
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Integrating LLMs and Causal Inference: Comparing Oral Anticoagulant Effects on Thrombosis Recurrence, Bleeding Risk and Death Using MIMIC-IV Data
… – 1.7% across outcomes.</p> <p>Causal effects of Vitamin K Antagonist (VKA) which was primarily Warfarin, and Factor Xa inhibitors (Apixaban, Edoxaban, Rivaroxaban) were estimated with targeted maximum likelihood estimation (TMLE), which uses initial Super Learner fits for the outcome and …
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
… P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been shown to affect warfarin response and favorably facilitate warfarin dosing and improve …
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Potential sources for the large scale production of human protein C
The vitamin K-dependent family of proteins (VKDs) include prothrombin, factors VII, IX, and X, and protein C (hPC) is synthesized in the liver and act to maintains normal hemostasis. such as properly regulated clotting. An imbalance of any of these pro- or anti-clotting proteins result in …
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Development of novel approaches for industrial fermentation of menaquinone-7
Vitamin K, an anti-haemorrhagic factor discovered by the Danish nutritional biochemist Henrik Carl Peter Dam in 1929, is capable of correcting dietary-induced bleeding disorders in chickens. It is essential for blood coagulation, and therefore must be supplied in the diet. Menaquinones (MK) …
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Expression of Human Protein C in Transgenic Tobacco
Human Protein C (hPC) is a vitamin K-dependent serine protease that has a critical role in the naturally-occurring anticoagulant pathway. Upon activation of the zymogen by thrombin at the endothelial cell surface, the active form of hPC has anticoagulant activity in hemostasis due to its ability to …
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