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Showing 1 to 20 of 28 for “"vitamin D receptor"”.
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
1,25-dihydroxyvitamin D3 (VitD) is a ligand for the Vitamin D Receptor (VDR, NR1I1), which is a member of the family of Nuclear Hormone Receptors (NHR). Previously, the Repa lab identified VDR as the fourth most abundant NHR in mouse islets based on mRNA levels, also, VDR is clearly present in …
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Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier
… function are upregulated upon activation by the vitamin D receptor (VDR) via its natural ligand 1α,25-dihydroxyvitamin D
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Influence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Training
… of the FokI and BsmI polymorphisms of the vitamin D receptor gene on changes in insulin sensitivity with aerobic exercise training in men and women at increased risk for type 2 diabetes mellitus (T2DM). Subjects were genotyped and underwent oral glucose tolerance tests before and after six …
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Role of Vitamin D receptor and vitamin D binding protein restriction fragment length polymorphisms in determining dose response to vitamin D: a randomized double blind placebo controlled trial
Serum 25-hydroxyvitamin D (25OHD) is considered to be the best biomarker of vitamin D status. Besides the dietary intake of vitamin D and exposure to sunlight, there are other factors that affect serum 25OHD such as weight, race, sex, binding protein and the effect of vitamin D receptor (VDR) and …
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Exploring MicroRNA as a Biomarker for Multiple Sclerosis (EMBleMS): A Pilot Study
… expression levels of microRNAs that affect the vitamin D receptor biosynthesis pathway is different in relapsing remitting multiple sclerosis, secondary progressive multiple sclerosis, and healthy controls and 2. The expression levels of microRNAs affecting the vitamin D receptor biosynthesis …
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Desensitization Of Basal Cell Carcinoma To The Anti-Tumoral Effect Of Vitamin D
<p>The relationship between Vitamin D and NMSC is not very clear. Most of human studies in literature in regards to vitamin D and NMSC are epidemiological which are inconsistent and inconclusive. Mechanistic studies about BCC are few, and mostly are animal models or cell cultures. The main goal for …
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ROLE OF AUTOPHAGY IN RADIOSENSITIZATION OF BREAST TUMOR CELLS
… by apoptosis). The hormonally active form of vitamin D, 1,25D3, also promoted autophagy in irradiated MCF-7 cells, sensitized the cells to radiation and suppressed the proliferative recovery that occurs after radiation alone. 1,25D3 also enhanced radiosensitivity and promoted autophagy in MCF7 …
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… the treatment options of RA, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the only steroidal drug used clinically for anti-inflammatory and immune diseases. However, long-term use of 1,25(OH)2D3 (625 µg/day) in human would result in hypercalcemia (toxicity), and 1,25(OH)2D3 has substantial …
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Model-Guided Transdermal Formulation of 1α,25-Dihydroxyvitamin D3 for Improved Safety and Efficacy
1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active ligand of vitamin D receptor (VDR), is useful for the prevention and treatment of various diseases, including chronic kidney disease (CKD), cardiovascular disease, hypercholesterolemia and neurodegenerative diseases. However, the therapeutic …
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Natural Genetic Variation Affecting Calcium Homeostasis
… Ca and increases renal conversion of 25 hydroxyvitamin D (25(OH)D) to 1,25 dihydroxyvitamin D (1,25(OH)2D). 1,25(OH)2D acts through the vitamin D receptor (VDR) to increase intestinal Ca absorption, renal Ca reabsorption and skeletal Ca resorption. Efficient intestinal Ca absorption, especially …
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
… to treatment is necessary to improve outcomes. Vitamin D is a hormone that acts as an immunomodulator and regulator of cellular proliferation with anticancer properties, and has been implicated in the prevention of some cancers. Its main source in light skinned individuals is the sun, and there …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
… in response to topical administration of the vitamin D3 analog MC903. Widespread increases in Tregs were observed in mice treated topically but not systemically with MC903. TSLP receptor (TSLP-R) but not hematopoietic vitamin D receptor signaling was important for this increase in Treg numbers …
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Skin Disease and Vitamin D
… There is a growing interest in the role of vitamin D beyond its effect on bone health. The vitamin D receptor is widely expressed in many different tissues, including the skin. Aim The aim was to investigate the association between 25-hydroxyvitamin D and cutaneous lupus erythematosus, and …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in a variety of human cell types, including prostate cancer cells. Therefore, downregulation of PTHrP gene expression by 1,25(OH)2D3 may enhance the therapeutic benefits of 1,25(OH)2D3 by …
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The Role of Vitamin D and Antipsychotic Drug-induced Weight Gain
… metabolic syndrome in this patient population. Vitamin D is essential in the normal functioning of the musculoskeletal system. However, its deficiency is prevalent. Vitamin D is involved in the pathology of mental illness, including schizophrenia. Furthermore, in recent years, it has also been …
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Role of the RUNX2 rs59983488 variant in bone mass determination and fracture risk in Malta
… of the RUNX2 gene, is predicted to alter vitamin D receptor (VDR) binding and several enhancer elements resulting in reduced gene expression and hence BMD. The aim of this study was to determine the genotype and allele frequencies of the RUNX2 rs59983488 variant in the Maltese population, …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
… the group of seco-steroids collectively termed Vitamin D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis et al., 2014b). Crucially, the …
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A New Pathway Responsible For 53BP1 Loss in Breast Cancer and Laminopathies
… Inhibiting CTSL using CTSL inhibitors or vitamin D treatment stabilizes levels of 53BP1 protein, leading to an increase in NHEJ and defects in HR. Stabilization of 53BP1 using CTSL inhibitors or vitamin D leads to increased genomic instability and compromises proliferation following …
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건선 피부에서 Toll-like receptors와 antimicrobial peptides의 발현과 혈청 내 비타민 D과의 관계
… rapid turnover of the epidermal keratinocytes. Vitamin D, Toll-like receptors (TLRs), and antimicrobial peptides (AMPs) such as human beta defensins (HBDs) and cathelicidins (LL-37) can modulate the immune system through a variety of ways in psoriasis. Purpose: The objective of the present study …
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