Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"virus-like particle"”.
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Severe Acute Respiratory Syndrome Coronavirus-2 Vaccine Development: A Virus-Like Particle Vaccine Approach
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 as a highly infectious virus that spread rapidly and was declared a pandemic by the World Health Organization (WHO) in March of 2020.1 SARS-CoV-2 infection causes respiratory disease (Coronavirus Disease; COVID-19), …
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Production of plant-expressed virus-like particle vaccines against infectious bronchitis coronavirus and vaccine efficacy in chickens
Infectious Bronchitis Virus (or IBV) is the root cause of extremely infectious respiratory disease that occurs in chickens. It has a high mutation rate that causes the emergence of multiple variants that are difficult to control, leading to major worldwide economic losses to the poultry industry. …
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An Investigation into the Use of a Plant-Expressed Virus-Like Particle as an Oral Vaccine Candidate
Abstract Plant-expressed virus-like particles (VLPs) could offer an alternative method for the oral delivery of vaccines. VLPs' robustness, combined with their compartmentalisation within the plant cells, should favour their stability in the harsh gastro-intestinal (GI) environment. In the small …
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Optimization of chimaeric HIV-1 virus-like particle (VLP) production and immunogenicity testing of VLPs in mice
… to be important in the eradication of the virus. One such approach is the use of HIV-1 Gag VLPs as vaccine candidates. In this study, the production of two chimaeric (Gag VLP vaccine candidates (GagRT and GagTN) was optimized in insect cells, and their ability to enhance a murine immune …
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The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models
… that vaccinations with the Vesicular Stomatitis Virus (VSV)-vectored HIV vaccine (VSVXN2∆G/CDO-EBOVGP+HIV-1 Codon-optimized A74_Env-EC/SIV_Env-TMCT) in Rhesus macaques provided protection to 50% of the animals against low-dose challenges with SHIVenv_SF162P infection, making it an effective …
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Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses
… is an advanced technology for treatment of oncoviruses leading cancers. However, lack of effective and safe vaccines against the oncoviruses has limited the development. This thesis aims to apply Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric …
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Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines
… caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the type-specific prevention of …
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
… Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise the T cell memory phenotype distribution in peripheral …
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
… of a chemically conjugatable Hepatitis B core virus-like particle system was also achieved.
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Consistent Fabrication of Ultrasmall PLGA Nanoparticles and their Potential Biomedical Applications
… last few decades. Specifically, ultrasmall nanoparticles, ranging in size from 5 to 50 nm, are highly sought after for their physical and chemical properties and their ability to be easily transmitted though the bloodstream. By adjusting the material properties, size, surface potential, …
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Expanding the toolkit of protease activatable viruses to improve their versatility and modularity
Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viral vectors. However, its adoption as a safe and effective gene therapy treatment for disease relies on targeting …
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Vaccine Development Against Porcine Epidemic Diarrhea Virus Utilizing the Hepatitis B Virus Core Antigen Protein
Porcine epidemic diarrhea Virus (PEDV) is a virus effecting swine. It is the cause of disease that manifests with symptoms ranging from depression, to severe dehydration and death. Young piglets are particularly susceptible to the virus, which can reach mortality rates of 100%. Presence of the …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea virus (PEDV) are two of the most prevalent swine pathogens that have impacted the global swine industry for decades. Both are RNA viruses with increasing heterogeneity over the years, making a vaccine solution …
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The production of foot-and-mouth disease virus-like particles in the plant Nicotiana benthamiana: a potential candidate vaccine for foot-and-mouth disease
Foot and mouth disease virus (FMDV) infects cloven-hoofed animals causing the highly contagious foot and mouth disease. It is spread by contact or through aerosol. The disease is often debilitating for infected animals and can be fatal. Severe measures are taken to contain outbreaks; quarantine and …
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Experimental and computational study of the mechanics of chikungunya
… caused by infections from microorganisms like human immunodeficiency virus (HIV), influenza virus, Ebola virus, Zika virus, dengue virus, and malaria have infected millions of people in Africa. In Africa, viruses with a viral envelope, i.e. enveloped viruses, like HIV and influenza, cause …
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Optimization and characterisation of plant produced Human Papillomavirus pseudovirions in Nicotiana benthamiana
Human papillomavirus (HPV) is known to be the cause of anogenital and oropharyngeal cancers as well as genital and common warts. There are currently three prophylactic virus-like particle (VLP) based vaccines. These vaccines, however, do not offer protection against all HPV strains and cannot act …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… and chimeric human papilloma (HPV) 16 L1 protein virus-like particles (VLPs). The chimeric protein was created by removing the last 34 C-terminal residues from the WT protein and then incorporating a multi-epitope insert that could universally target major histocompatibility complex (MHC) class II …
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Intranasal Immunization of Pigs with Porcine Reproductive and Respiratory Syndrome Virus like Particles Plus 2’, 3’ –cGamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge
<p>Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically devastating virus that causes a persistent infection and spreads quickly. The virus causes abortions in sows and respiratory diseases in young piglets. Current PRRSV vaccines appear to provide limited …
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Investigation of particulate Bluetongue virus vaccines made in plants
Bluetongue virus (BTV) infects ruminants but predominantly causes severe and often fatal haemorrhagic fever, known as Bluetongue (BT) disease, in sheep. Increasing global temperatures have contributed to the global dissemination of BTV. This is a result of the Culicoides insect vectors which …
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