Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"virus-host interactions"”.
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AC electrokinetic studies of virus host interactions
Abstract available p. iii
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Investigating virus-host interactions in a changing Arctic Ocean
… understood. The AO is also a hotspot for giant virus diversity, and M. polaris is susceptible to infection by giant viruses known as Micromonas polaris viruses (MpoVs). Previous research has characterised MpoV infection dynamics and the potential for these to be affected by warming, yet genomic …
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Virus-host interactions in the cassava brown streak disease pathosystem
The research seeks to understand the virus-host plant interactions for cassava brown streak disease (CBSD) caused by two viruses, Cassava brown streak virus (CBSV) and Ugandan Cassava brown streak virus (UCBSV) of the genus Ipomovirus, family Potyviridae. The diversity of six CBSD isolates from the …
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VIRUS-HOST INTERACTIONS AND THE IMPACT ON HOST CELLULAR MECHANISMS
Paramyxoviridae constitutes an RNA-genome virus family that includes the emergent and deadly Nipah (NiV) and Hendra (HeV) viruses. These viruses possess substantial pandemic potential and exhibit an expansive host range, a characteristic underpinned by their conserved ephrin receptors. Being a …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
BK polyomavirus (BKPyV) is a small, non-enveloped dsDNA virus that infects 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop …
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Virus-Host Interactions during Epstein-Barr virus Latent Infection of B cells
<p>Epstein-Barr virus latently infects over 90% of the adult global population. While it generally results in a completely asymptomatic lifelong infection, EBV is associated with and the causative agent of several human malignancies, particularly in cases of immune suppression. There is extensive …
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The Role of Virus-Host Interactions in the Evolutionary Dynamics of Bacteriophage Populations
Bacteriophage (phage) are viruses which infect and replicate within bacteria cells. Phages replicate by finding a host bacteria cell, adsorbing to it, injecting their DNA, hijacking the host machinery to produce more phage, and finally lysing the cell to release the new phage. The evolutionary …
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Molecular characterization of tomato brown rugose fruit virus-host interactions and development of biocontrol strategies
Tomato brown rugose fruit virus (ToBRFV, Tobamovirus fructirugosum) is an emerging RNA virus that threatens global tomato production. The virus can break down durable extreme resistance (ER) to its related tobamoviruses conferred by the NLR gene Tm-22. Currently, no effective control strategies are …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the cell and alerts neighboring cells of viral invaders. Recognition of dsRNA …
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Adeno-associated virus type 2 as vector for human gene therapy: Characterization of virus-host interactions
Vectors based on adeno-associated virus type 2 (AAV) offer considerable promise for somatic gene therapy of various diseases (e.g. cystic fibrosis, hemophilia B, cancer). Limitations, however, still exist and require further improvement. The study presented here addresses two major problems that …
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Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus
West Nile virus (WNV) has rapidly become a pathogen of global importance over the past two decades. Its recent association with severe neurological disease and emergence in the Western Hemisphere suggest that the virus has acquired the ability to effectively evade host immune defenses. One of the …
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Examining patterns of CRISPR immunity in natural populations of Sulfolobus islandicus
Virus-host interactions are important for shaping microbial diversity in natural environments. Viruses impact their hosts through predation and also through gene flow. The recently discovered microbial CRISPR immune system is a mechanism that modulates interactions between hosts and viruses, and in …
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Structural Studies On The Rubella Virus Capsid Protein And Its Organization In The Virion
<p>Rubella virus is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, rubella infection leads to severe damage in fetuses. Despite its medical importance, very little is known about the structure of the pleomorphic rubella virus as compared to its …
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Identification and Characterization of Novel Caenorhabditis Nematode Viruses
… been broadly considered for investigating host-pathogen interactions. During this time a number of bacterial, fungal, and microsporidial pathogens were shown to infect C. elegans; however, until recently, no natural viruses were known, resulting in a limited understanding of virus-host …
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Bovine parvovirus and bovine enterovirus in mixed infections
… 2mM hydroxyurea were infected with bovine parvovirus and bovine enterovirus in order to study the events occurring when DNA and RNA viruses mixedly infect single cells. The objectives of this research were threefold. First, to determine the effects of single infection of synchronized bovine …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
Rotavirus (RV) is a leading cause of diarrhoea in young children. In 2016, rotavirus-related death was estimated around 128,500, with 258,173,300 episodes of diarrhoea in children below 5 years. Although extra-intestinal rotavirus infection is limited, the spread of the virus can cause seizures and …
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Evolutionary and ecological consequences of chronic infection in Sulfolobus islandicus
… not often considered from this perspective, virus-host interactions represent a symbiotic interaction that exists along a continuum from antagonistic to mutualistic. In microbial ecology and evolution, this relationship has mostly focused on antagonistic lytic viruses. Lytic viruses are …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
Arenaviruses are viruses that can cause severe and deadly hemorrhagic fever infections in Africa and South America, including Lassa virus that causes Lassa fever in several countries in west Africa. There are currently no vaccines and very limited therapeutics available for Lassa fever. There are …
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Mechanistic interactions between Sulfolobus islandicus and its viruses
Viruses infect all domains of life and play important ecological and evolutionary roles. In studying these virus-host interactions, fundamental mechanisms in cellular and molecular biology have been elucidated. The viruses of Sulfolobus are diverse in morphology, genomic content, and infection …
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Identification of host cellular factors that regulate human norovirus replication
The human norovirus (HuNoV) is one of the most predominant causes of gastroenteritis, yet no suitable therapeutics are available for its control. Currently, our knowledge of the precise cellular processes that control its replication is limited. In this study, we used the virus replicon system in …
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