Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 292 for “"virus infection"”.
-
Factors That Influence Mammalian Enteric Virus Infection
RNA viruses are a common cause of emerging diseases due to their vast genetic diversity. This diversity is largely attributed to mutations generated by the error-prone viral RNA-dependent RNA polymerase during replication. Despite the ability to acquire mutations beneficial to the virus, most …
-
Host response to Rift Valley fever virus infection
Rift Valley fever virus (RVFV) has the ability to cause severe disease (in the form of encephalitis or hemorrhagic fever) in humans and animals. RVFV is endemic to parts of Africa and the Arabian Peninsula, but there is significant concern regarding its potential introduction into non-endemic …
-
Dengue virus infection. Clinical assessment, pathophysiology and management.
Contains fulltext : 49261.pdf (Publisher’s version ) (Open Access)
-
Pseudorabies Virus Infection of Porcine Peripheral Blood Leukocytes
Pseudorabies virus (PRV) is an alphaherpesvirus of swine that causes significant morbidity in adult populations, morbidity and mortality in young pigs, and economic losses to the swine industry each year. Evidence suggests that PRV causes immunosuppression in infected swine with resultant risk of …
-
T-lymphocyte senescence and hepatitis C virus infection
Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of …
-
Intrinsic genetic resistance of lymphocytes to influenza virus infection
… with protection of lymphocytes against infection by influenza virus. There was absence of viral transcription in the lymphocytes of HLA-A homozygous subjects, although all monocytes were infected.\r\nMy specific aim was to determine if such resistance was evident in HLA-B homozygous …
-
Innate immunity in Zika Virus infection and neurogenesis deficits
Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised public health concerns globally. Clinical and animal studies have shown that miscarriage and brain malformation are more frequent when infection occurs during early pregnancy. ZIKV-associated microcephaly is most likely …
-
Enhancement Of Ebola Virus Infection By Seminal Amyloid Fibrils
… West Africa epidemic was the worst Ebola virus outbreak on record, with the infected numbering over 28,000 and the dead more than 11,000. Among those who survived the disease, Ebola virus was found to persist in numerous anatomical locations and be shed in semen. During the West Africa …
-
The response of eIF2α kinases to plant virus infection
… of eIF2α kinases, including a putative PKR, to virus infection. It is not clear whether in plants, as in other eukaryotes, if phosphorylation of eIF2 regulates translation of mRNAs with particular uORFs. To determine whether this type of regulation occurs in plants, a Luciferase/Renilla …
-
Genomic profiling and perturbation of Hepatitis B virus infection
The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, and the development of hepatocellular carcinoma over decades. While an …
-
A mouse model for the pathogenesis of immunodeficiency virus infection
… loss. These mechanisms eventually fail in HIV infection, which is characterized by progressive immune deficiency attributable to a slow but relentless depletion of CD4+ T cells, the main viral targets. HIV infection is also associated with increased T cell turnover and a state of generalized …
-
Identification of Host Factors Required for Hepatitis C Virus Infection
Hepatitis C virus (HCV), a positive-strand RNA virus, infects more than 170 million people and is the leading cause of liver failure worldwide. A protective vaccine is not yet available. Current interferon-based therapies are only effective in a fraction of patients. Thus, there is an urgent need …
-
Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
-
Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
-
Characterization of Hepatitis C Virus Infection of Hepatocytes and Astrocytes
… is currently infected with hepatitis C virus (HCV). Neutralizing antibodies (nAbs) are often generated in chronic hepatitis C patients yet fail to control the infection. In the first two chapters of this study, we focused on two alternative routes of HCV transmission, which may …
-
Investigating the role of Sialoadhesin in Influenza A virus infection
… mediate the uptake of a sialylated respiratory virus to initiate infection, it remains unclear if Sn will be able to recognize a pathogen devoid of terminal Sia, but triggers its upregulation through a type I IFN response. The aim of this thesis is therefore, to address Sn’s regulation of …
-
Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
Chronic hepatitis B virus (HBV) infection causes liver disease that can progress to cirrhosis and hepatocellular carcinoma (HCC). Changes in the hepatocyte population that occur from the early immune-tolerant stage of infection to late-stage disease outcomes remain unclear. We hypothesised that …
-
Contagious ecthyma virus infection of sheep: virologic and immunologic investigations
… not fully protected when reinoculated with CE virus 4 weeks later. The size of the primary vaccination lesions, virus neutralizing antibody titers and virus-specific lymphocyte stImulation indices could not be used to predict the degree of protective immunity. Measurement of the neutralizing …
Page 1 of 15