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Showing 1 to 12 of 12 for “"virus capsid"”.
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Statistical Mechanical Models Of Virus Capsid Assembly
Viruses have become an increasingly popular subject of physics investigation, particularly in the last decade. Advances in imaging of virus capsids-the protective protein shells-in a wide variety of stages of assembly have encouraged physical assembly models at a similarly wide variety of scales, …
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Design of a large-scale virus capsid model for educational use
A foot-scale model of an icosahedral virus capsid, as opposed to a helical capsid shape, was modeled in preparation for manufacture for educational use. We chose to model the icosahedral virus capsid for manufacture because understanding the structure of this type of capsid is of biological …
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Design and manufacturing of a physical model of an icosahedral virus capsid
Viruses enclose genetic material, DNA or RNA, that are the cause of several diseases and conditions suffered by humans such as Influenza, Chickenpox, Smallpox, Herpes, and Hepatitis C. It is for this reason that viruses are of interest to us. By studying the virus, we can develop methods to …
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Modulation of West Nile Virus Capsid Protein and Viral RNA Interaction through Phosphorylation
West Nile virus (WNV) is a mosquito-borne flavivirus, which can cause fatal meningoencephalitis. Although studies have been done to examine virus life cycle, the mechanisms that regulate its assembly are unknown. This study aims to characterize the interaction between WNV viral RNA and the capsid …
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Structural Studies On The Rubella Virus Capsid Protein And Its Organization In The Virion
<p>Rubella virus is a leading cause of birth defects due to infectious agents. When contracted during pregnancy, rubella infection leads to severe damage in fetuses. Despite its medical importance, very little is known about the structure of the pleomorphic rubella virus as compared to its …
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Cryo-electron microscopy of HPV16 pseudovirions reveal changes in capsid conformation upon furin cleavage
Persistent infection by oncogenic human papillomavirus (HPV) is the primary cause of cervical cancer, a leading cause of cancer deaths in women worldwide. There are no treatments for HPV infection, and although prophylactic vaccines are effective and safe, they are HPV type specific, provide little …
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Decontamination of food and food-processing surfaces from norovirus by cold atmospheric-pressure gaseous plasma
Human Norovirus (HuNoV) is a leading cause of acute foodborne gastroenteritis outbreaks and sporadic cases. The estimated burden of HuNoV on public health is 685 million and 20 million illnesses each year in the world and the US, respectively. This results in approximately $4.3 billion and $60.3 …
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Investigation into the mechanism of immature HIV-1 capsid assembly
The major structural protein of the retrovirus HIV-1 is called Gag and is expressed as a 55<br/>kDa poly-protein with six contiguous domains. These are labelled from the N-terminus as<br/>MA, CA, SP1, NC, SP2 and P6. There are two distinct assembly steps in the lifecycle of<br/>HIV-1, termed …
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PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
Herpes simplex virus entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome …
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Development of Rapid Lateral-flow Immunochromatographic Test for the Diagnosis of Chikungunya Virus Infection
BACKGROUND/AIMS: Chikungunya (CHIK) virus is a mosquito-transmitted Alphavirus belonging to family Togaviridae that causes a number of outbreaks in Africa, India, and Southeast Asia with high morbidity. The major clinical symptoms resulting from CHIK virus infection are high fever, arthralgia, …
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Autonome Parvoviren
… in adult animals make the two rodent parvoviruses MVMp and H1 promising vectors for cancer gene therapy. Recombinant vectors were developed from genomes of these viruses in which a part of the capsid-protein-coding sequence was replaced by a transgene. These recombinant viruses can …
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Molecular modeling and simulations of viruses: structure, dynamics and antibody design
… to investigate the dynamic properties of virus capsids, to determine the atomic structure of highly-flexible capsid domains, which could not be solved using a single experimental method, and to unravel the molecular mechanisms of host-pathogen interactions. Furthermore, we have recently …