Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"virus budding"”.
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The analysis of Autographa Californica multiple Nucleopolyhedrovirus EXONO (ORF141) function and its role in virus budding
Baculoviruses have a biphasic replication cycle producing two types of virions, budded virus (BV) and occlusion derived virus (ODV) which are required for the systemic spread or oral infection with the insect host respectively. Little is known about the events of the BV pathway and the mechanism by …
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Formation of membrane domains induced by the G and M proteins of vesicular stomatitis virus
Vesicular stomatitis virus (VSV) buds from specialized regions or domains on the plasma membrane of infected cells. These domains are composed mainly of viral proteins and they are enriched in certain lipid species. The properties of the two envelope-associated proteins of VSV, the glycoprotein (G) …
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Structure and dynamics of influenza M2 proton channels from solid-state NMR
The A and B strains of influenza virus places a substantial burden on health, causing around 30 million illnesses, several hundred thousand hospitalizations, and a few tens of thousands of deaths every year in the United States alone. Developing novel antiviral and vaccines against influenza …
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Investigating the Role of Stem-Loop 1 in the Assembly Process of HIV-1
… infectious HIV-1 particles is maturation of the virus core. This process is completed by cleavage of the capsid (CA) domain of Gag, from its precursor, CA-SP1, by the viral protease. Large deletions in stem-loop 1 (SL1) in the 5’ untranslated region (UTR) of HIV-1 genomic RNA (gRNA) delay CA-SP1 …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Expression Of Cholera Toxin B Subunit-rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts
Rotavirus, the major cause of life-threatening infantile gastroenteritis, is a member of the Reoviridae family and is considered to be the single most important cause of virus-based severe diarrheal illness in infants and young children particularly 6 months to 2 years of age in industrialized and …
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Biosynthesis and engineering of lanthipeptide natural products for novel applications
… against the UEV-p6 interaction during HIV virus budding from the host cell. The hit compound generated from the selection exhibited in vitro activity against the target PPI, demonstrating for the first time that an active lanthipeptide natural product could be successfully evolved from an …
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Structural and biochemical characterisation of pUL7 and pUL51, conserved tegument proteins required for efficient herpesvirus assembly
Herpesviruses are ubiquitous viral pathogens that infect all known vertebrates. It is estimated that over 90% of adults worldwide are infected with at least one of the nine human herpesviruses, which cause a wide range of morbidity and mortality. These viruses share a conserved assembly pathway, …
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Investigation and application of substrate tolerant thioether forming enzymes
… human TSG101 protein, which is essential for HIV virus budding from infected cells. A detailed in vitro characterization was performed to identify the binding site of XY3-3 using fluorescence polarization. XY3-3 competes with full length p6 protein for binding to UEV. To optimize XY3-3, two yeast …
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The Structure and Replication of a Parainfluenza Virus
<p>The simian parainfluenza virus SV5 is a member of myxovirus subgroup II, which includes parainfluenza, mumps, and Newcastle disease viruses. These viruses are 120-500 mμ in diameter, and consist of an envelope covered with surface projections and an internal ribonucleoprotein component which is …