Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"virulence regulation"”.
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Mechanisms of Virulence Regulation in Porphyromonas gingivalis W83
… in both prokaryotic and eukaryotic systems. This regulation can occur at multiple levels including expression of the protease genes, secretion, processing of an inactive secreted precursor to its active form and/or the posttranslational glycosylation of the proteins. These regulatory mechanisms …
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Quorum Sensing and Virulence Regulation in Commensal and Pathogenic Bacteria
… including genetic competence, biofilm formation, virulence, and horizontal gene transfer. In streptococci, QS commonly occurs through the ComABCDE and ComRS signaling pathways, which coordinate transcriptional responses through competence-associated regulators such as ComX. Although canonical …
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Biofilm and Virulence Regulation of the Cystic Fibrosis Associated Pathogens, Stenotrophomonas maltophilia and Pseudomonas aeruginosa
… subsequent or concurrent altered genetic regulation, including a downregulation of virulence factors, resulting in the bacteria committing to a sessile lifestyle, markedly different from the planktonic one. Many of these genetic switches from an acute to chronic lifestyle are due to …
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The Characterization of the Fucose Sensing Kinase (FUSK) and the Fucose Sensing Response Regulator (FUSR) and Their Role in Virulence Regulation in Enterohemorrhagic Escherichia Coli O157:H7
… fusR, and investigated their participation in virulence gene regulation in EHEC. Microarray analysis shows that deletion of fusK and fusR alters transcription of virulence and metabolic genes. Phenotypic analyses show that fusK- and fusR- strains are hypervirulent in vitro, overexpress the LEE …
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Posttranscriptional and posttranslational regulation of virulence in erwinia amylovora
… disease of the Rosaceae family plants. Two virulence factors, the type III secretion system (T3SS) and the exopolysaccharide (EPS) amylovoran, are strictly required for its pathogenicity. Our previous studies have determined the role of several transcription factors in the regulation of E. …
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Functional Domains in the Multigene Regulator of the Group A Streptococcus
… shown to bind DNA and activate transcription of virulence genes implicated in colonization and immune evasion in response to environmental conditions. Several different avenues of investigation were undertaken in the present study with an overall goal of identifying and characterizing functional …
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The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage
… in group A streptococci and how they impact virulence regulation. With this work, we hoped to identify new regulatory elements involved in the infection process. The first objective of this thesis was to determine the transcriptional shift induced in streptococci upon introduction into the in …
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Mechanism of Signal Transduction By The Staphylococcus Aureus Quorum Sensing Receptor AGRC
… its overall population in order to synchronize virulence factor expression with the entire population. This task is carried out by the accessory gene regulator (agr) quorum sensing system. The agr autoinducing peptide (AIP) pheromone activates the AgrC receptor histidine kinase, resulting in …
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Investigation of the role of the extracellular β-agarase, produced by the bacterial epiphyte Pseudoalteromonas sp. LS2i, in the virulence response towards the agarophyte Gracilaria gracilis
… sp. LS2i to further our understanding of virulence regulation and specifically, the role of the agarase enzymes in the process of seaweed-pathogen interaction. Two agarolytic clones, pEB1 and pJB1, were obtained after constructing and screening a Pseudoalteromonas sp. LS2i genomic library …
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Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence
… protein assemblies responsible for regulating virulence in the opportunistic pathogen Pseudomonas aeruginosa. P. aeruginosa utilizes type IV pili (T4P) to adhere to, and move along, surfaces. Assembly of T4P is powered by a dedicated cytoplasmic ATPase, PilB. The structural study of PilB from a …
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Structural Basis of Bacterial Transmembrane Signaling
… known multikinase network. GacS upregulates virulence factors associated with biofilm formation and chronic infections. Sensor histidine kinase-like RetS directly inhibits GacS to promote the expression of virulence factors linked to acute infection and suppress those required for chronic …