Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"virulence mechanisms"”.
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Characterization of Virulence Mechanisms in Vibrio parahaemolyticus
Pages xvi-xix are misnumbered as pages vi-ix.
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Investigation of Novel Virulence Mechanisms In Candida Albicans
… albicans </em>adaptation to the host and the mechanisms by which this organism is able to survive and cause infection through a variety of means. A key determinant in disease progression is interaction with innate immune cells, specifically macrophages and neutrophils. Due to the few options …
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Understanding Virulence Mechanisms of Parasitoid Wasps of Drosophila: A Comparative Approach Across Clades
… melanogaster</em> is suppressed. A putative virulence protein, SSp40 in <em>L. heterotoma</em> EVs, triggers lamellocyte lysis. SSp40 is structurally similar to the bacterial IpaD and SipD proteins. The immune-suppressive mechanisms of closely related heterotoma clade wasps, <em>L. …
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Genomic Instability and Gene Dosage Obscures Clues to Virulence Mechanisms of F. tularensis species
… [wbtK+]TIGB03, with dramatic differences in virulence and growth rates. One of the complemented clones (Clone12 or avp-[wbtK+]TIGB03-C12) was aviru-lent, but protected mice against challenge of a lethal dose of TI0902 and was considered as a possible vaccine strain. Whole genome sequencing …
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… Therefore, Klebsiella employs a range of novel mechanisms, including the targeting of host post-translational modifications (PTMs), to attenuate inflammation. The Bengoechea laboratory has previously demonstrated that Klebsiella triggers a type I interferon (IFN) response in vivo and here it is …
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New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen
… pathogenesis of Y. pestis and identifying new virulence factors is warranted. Although the natural route of primary infection with Y. pestis results in bubonic plague in humans, it is commonly thought that aerosolized Y. pestis will be utilized during a biowarfare attack. Therefore, the purpose …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… diseases in humans, produces many different virulence factors. A clinical isolate SSU of A. hydrophila possesses a cytotoxic enterotoxin Act, a potent virulence factor that is secreted into the environment through the bacterium’s type 2 secretion system (T2SS) and possesses several biological …
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Existing regulatory circuitries govern backbone and acquired host association factors in the human pathogen Vibrio parahaemolyticus
… human gastrointestinal pathogen whose virulence mechanisms are not well understood. Though closely related to Vibrio cholerae, V. parahaemolyticus infections are inflammatory and utilize virulence traits that are unique from the Cholera toxins yet remain poorly characterized. Vibrio …
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Pertussis: Advances in Vaccine Development and Disease Control Strategies
… and disease control strategies. It emphasizes virulence factors such as Vag8, SphB1, BrkA, and BapC as potential components for acellular vaccines. Additionally, it discusses current trends in pertussis research and development, including mRNA vaccines and live-attenuated vaccines, as well as …
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Inheritance of virulence in the root rot pathogen Phytophthora sojae
… of soybean plants. The interaction of pathogen avirulence (Avr) and host resistance (R)-genes determine the disease outcome. The Avr3a mRNA transcript level is variable among P. sojae strains and determines virulence towards the R-gene Rps3a. To study the inheritance of virulence, genetic crosses …
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Potential Approaches to Limiting Group A Streptococcus Virulence
… on two potential approaches to limiting GAS virulence. First, we investigated GAS mechanisms of copper tolerance. Copper plays an important role in the development and maintenance of the human immune system. Macrophages utilize copper as an additional stressor to aid in bacterial killing. In …
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
… a spike in growth rates and genes geared toward virulence mechanism of P. aeruginosa. In contrast, higher concentrations (0.5, 1mM), overall induced downregulation of virulence mechanisms controlling pyocyanin, rhamnolipids, and elastase production, inhibiting quorum sensing.
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Characterization of VIBRIO Parahaemolyticus-Induced Intestinal Inflammation in the Mouse
… warming and emphasizes the need to study the virulence mechanisms of the pathogen. V. parahaemolyticus utilizes a type III secretion system to inject effectors that disrupt signal transduction in eukaryotic hosts during infection. Herein, we describe an in vivo model of infection by V. …
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Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
… A basic understanding of Cryptococcus virulence mechanisms and survival strategies is required to combat the infections and develop therapies through translational research. Considering the evidence of a role of DNA repair in pathogenesis, I investigated DNA repair strategies adopted by …
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Unveiling and exploiting <i>Phytophthora capsici</i> effectors and their host targets, with an emphasis on CRN effector proteins
… is a devastating plant pathogen for which virulence is aided by the secretion of effectors, including cytoplasmic effectors from the CRN (CRinkling and Necrosis) family.<br/><br/>CRN effectors were first described in oomycetes by their capacity to induce host cell death. Nevertheless, …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… Relatively little is known regarding the virulence mechanisms of B. pseudomallei; however, several putative virulence determinants have been identified. The organism is able to invade and replicate within phagocytic cells and is particularly pathogenic in males with diabetes mellitus. B. …
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Streptococcal virulence and the coagulation system.
This thesis explores streptococcal virulence from both mechanistic and evolutionary perspectives, where the mechanistic studies focus on interactions with the human coagulation system. We describe interactions between streptococcal surface proteins and components of the intrinsic pathway of …
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Structural Analysis of Cycle Inhibiting Factor from Pathogenic Escherichia Coli
… have evolved a sophisticated arsenal of virulence factors to modulate host cell biology. Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) use a type III protein secretion system (T3SS) to inject microbial proteins into host cells. These translocated proteins possess …
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The Chlamydia Trachomatis Protein Interaction Network: Insights into the Unique Composition of the Type Three Secretion System
… manipulates host cellular functions by secreting virulence factors across its membrane bound vacuole. Identifying these virulence components and how they help in establishing an environment conducive for bacterial growth is central to understanding chlamydial pathogenesis. This is experimentally …
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