Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"virulence gene expression"”.
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Coordinate Regulation of Salmonella Virulence Gene Expression During Infection
… in S. typhimurium. We show that RtsA increases expression of the invasion genes by inducing hilA expression. RtSA also induces expression of hilD, hilC, invF, and slrP. RtsA induction of these genes is independent of other SPI1 regulators. RtsA directly induces hilA expression by binding to the …
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The transcriptional control of virulence gene expression in Helicobacter pylori
… focused so far on the mechanisms that regulate expression of these factors at the molecular level. In an attempt to obtain an overview of the basic mechanisms of virulence gene expression in H. pylori, three important virulence factors of this pathogen, representative of different pathogenic …
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Virulence gene expression of three hypervirulent S. pyogenes M1T1 and membrane vesicles isolation
… activity against S.pneumoniae and S.pyogenes and a potent capacity of adhesion to HEp-2 cells. The main aim of this study was to evaluate the clinical evidence of a probiotic application of S.salivarius 24SMBc for the prevention or reduction of recurrent medium otite (OM) children …
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CONTRIBUTIONS OF SIGMA-B AND PRFA TO STRESS RESPONSE AND VIRULENCE GENE EXPRESSION IN LISTERIA MONOCYTOGENES
… food borne bacterial pathogen Listeria monocytogenes has several mechanisms for regulating expression of stress response and virulence genes. The alternative sigma factor sigmaB is a global regulator of genes active under environmental stress conditions and during stationary phase growth. I …
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The Mechanism For Inhibition Of Vibrio Cholerae Virulence Gene Expression By Bile And Its Fatty Acid Components
… diarrheal disease cholera by producing two major virulence factors: cholera toxin (CT) and toxin-coregulated pilus (TCP). During infection, <i>V. cholerae</i> downregulates its motility genes, which are actively expressed in the environment, and upregulates its virulence genes, which are inactive …
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Effects of low molecular weight compounds on growth, virulence gene expression and cytotoxic activity of Shiga toxin-producing Escherichia coli O157:H7
… compound (LMWC) capable of inhibiting various virulence gene expressions in E. coli O157:H7 has been identified, which could help mitigate its pathogenicity at certain time points in its infection. Our own previous studies showing significant down-regulation of virulence gene expression in …
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Studies Toward the Syntheses of Antiarrythmic, Anti-Virulence, and Anticancer Small Molecules
… of potent inhibitors of QseC mediated virulence gene expression, and c) studies toward a biomimetic total synthesis of nigricanoside A. Antiarrhythmic analogs of 17(R),18(S)-epoxyeicosatetraenoic acid (17(R),18(S)-EEQ): Arrhythmias such as atrial and ventricular fibrillation are a …
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Understanding small RNA-mediated post-transcriptional regulation of Salmonella pathogenicity island 1 activator HilA in Salmonella typhimurium
… and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory circuit. The …
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Functional Similarity of Prd-Containing Virulence Regulators In Bacillus Anthracis
… regulators, AtxA, AcpA, and AcpB, that control virulence gene expression and are members of an emerging class of regulators termed “PCVRs” (Phosphoenolpyruvate-dependent phosphotransferase regulation Domain-Containing Virulence Regulators). AtxA controls expression of the toxin genes; <em>lef, …
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Characterization of major virulence regulators of Erwinia amylovora
… type III secretion system (T3SS) are two major virulence factors in E. amylovora. However, how these virulence factors are regulated is not completely understood. In bacteria, gene expression is mainly regulated at the transcription initiation level and its core RNA polymerase (RNAP) requires …
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… sense these molecular signatures and modulate gene expression to colonize this niche. An invading intestinal pathogen, to effectively colonize the gut, must sense and respond to the molecular signatures in the gut, which leads to effective colonization and infection. Diet is the principal …
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In Vivo Gene Expression Profiling of the Plague Bacillus, Yersinia Pestis
… is valuable to better understand plague pathogenesis. Improved understanding of the mechanisms employed by Y. pestis to cause illness may lead to new vaccines or therapies. Using a long-oligonucleotide microarray to the plague bacillus I evaluated the expression profiles of in vitro and in …
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Studies on the occurrence of antibiotic-resistant bacterial strains from agriculture-associated waters and their proteomic and genomic characterizations
… communities via horizontal and vertical gene transfer. Natural environment acts as a centre stage for such events and act as reservoir for antibiotic resistant bacteria. Anthropogenically polluted rivers can act as one such reservoir.<br/><br/>This thesis explores this possibility and …
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Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… larvae, possessing optical transparency and genetic tractability, offer an accessible and clinically relevant model for investigating dynamic events in the intestine via time-lapse imaging. In the first part of this work, I discuss our efforts to optimize the parameters of a foodborne …
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CcpA-Mediated Carbon Catabolite Repression of Virulence in the Group A Streptoccus
… such as necrotizing fasciitis. The coordinate expression of a wide array of virulence factors in response to the changing host environment represents a key step in the ability of the GAS to mediate disease in the human host. The present study investigates the role of the primary mediator of …
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Insights into the Substrate Binding Specificity of Quorum-Quenching Acylase PVDQ
… inhibiting the biofilm formation and reducing virulence gene expression. Previous studies demonstrated that PvdQ has different preferences for AHLs with different acyl chain lengths and substituents. However, the substrate binding specificity determinants of PvdQ with different bacterial …
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Regulation of amylovoran biosynthesis in Erwinia amylovora
… stimuli and usually respond by regulating gene expression. One of the extensively studied TCSTs in enteric bacteria is the Rcs phosphorelay system (RcsCDB), which regulates numerous phenotypes such as exopolysaccharide production, swarming motility and bacterial virulence. Orphan genes …
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Characterizing induced gene expression in Shigella flexneri following bile salt exposure
… bile salts as signals for invasion and virulence gene expression. This study aimed to build upon previous research analyzing the bile salts transcriptional profile of Shigella flexneri 2457T, in which an induction of the uncharacterized gene was demonstrated during bile salts exposure. …
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The Influence of The Pep-Pts and Other Metabolic Systems On The Master Virulence Regulator Atxa and to xin Gene Expression In Bacillus Anthracis
<p>AtxA, the master virulence gene regulator in <em>Bacillus anthracis,</em> is a PRD-containing virulence regulator (PCVR) as indicated by the crystal structure, post-translational modifications, and activity of the protein. PCVRs are transcriptional regulators, named for the regulatory domains …
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Reconstitution and Mechanistic Studies on the Staphylococcal agr Quorum Sensing Circuit
<p>Quorum sensing (QS) plays a central role in virulence induction in the commensal pathogen, Staphylococcus aureus. This bacterium secretes an auto-inducer peptide (AIP), a small, cyclic peptide containing a thiolactone linkage as an indicator of its population density, and up-regulates virulence …
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